IF2B_THEGJ
ID IF2B_THEGJ Reviewed; 142 AA.
AC C5A2A8;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Translation initiation factor 2 subunit beta {ECO:0000255|HAMAP-Rule:MF_00232};
DE AltName: Full=aIF2-beta {ECO:0000255|HAMAP-Rule:MF_00232};
DE AltName: Full=eIF-2-beta {ECO:0000255|HAMAP-Rule:MF_00232};
GN Name=eif2b {ECO:0000255|HAMAP-Rule:MF_00232}; OrderedLocusNames=TGAM_2025;
OS Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=593117;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15229 / JCM 11827 / EJ3;
RX PubMed=19558674; DOI=10.1186/gb-2009-10-6-r70;
RA Zivanovic Y., Armengaud J., Lagorce A., Leplat C., Guerin P., Dutertre M.,
RA Anthouard V., Forterre P., Wincker P., Confalonieri F.;
RT "Genome analysis and genome-wide proteomics of Thermococcus gammatolerans,
RT the most radioresistant organism known amongst the Archaea.";
RL Genome Biol. 10:R70.1-R70.23(2007).
CC -!- FUNCTION: eIF-2 functions in the early steps of protein synthesis by
CC forming a ternary complex with GTP and initiator tRNA.
CC {ECO:0000255|HAMAP-Rule:MF_00232}.
CC -!- SUBUNIT: Heterotrimer composed of an alpha, a beta and a gamma chain.
CC {ECO:0000255|HAMAP-Rule:MF_00232}.
CC -!- SIMILARITY: Belongs to the eIF-2-beta/eIF-5 family. {ECO:0000255|HAMAP-
CC Rule:MF_00232}.
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DR EMBL; CP001398; ACS34527.1; -; Genomic_DNA.
DR RefSeq; WP_015859630.1; NC_012804.1.
DR AlphaFoldDB; C5A2A8; -.
DR SMR; C5A2A8; -.
DR STRING; 593117.TGAM_2025; -.
DR PaxDb; C5A2A8; -.
DR EnsemblBacteria; ACS34527; ACS34527; TGAM_2025.
DR GeneID; 7987082; -.
DR KEGG; tga:TGAM_2025; -.
DR PATRIC; fig|593117.10.peg.2035; -.
DR eggNOG; arCOG01640; Archaea.
DR HOGENOM; CLU_026663_3_1_2; -.
DR OMA; FIRYYVV; -.
DR OrthoDB; 96453at2157; -.
DR Proteomes; UP000001488; Chromosome.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00232; eIF_2_beta; 1.
DR InterPro; IPR045196; IF2/IF5.
DR InterPro; IPR004458; TIF2_bsu_arc.
DR InterPro; IPR002735; Transl_init_fac_IF2/IF5_dom.
DR InterPro; IPR016189; Transl_init_fac_IF2/IF5_N.
DR InterPro; IPR016190; Transl_init_fac_IF2/IF5_Zn-bd.
DR PANTHER; PTHR23001; PTHR23001; 1.
DR Pfam; PF01873; eIF-5_eIF-2B; 1.
DR SMART; SM00653; eIF2B_5; 1.
DR SUPFAM; SSF100966; SSF100966; 1.
DR SUPFAM; SSF75689; SSF75689; 1.
DR TIGRFAMs; TIGR00311; aIF-2beta; 1.
PE 3: Inferred from homology;
KW Initiation factor; Protein biosynthesis.
FT CHAIN 1..142
FT /note="Translation initiation factor 2 subunit beta"
FT /id="PRO_1000204383"
SQ SEQUENCE 142 AA; 16325 MW; 316FB7EC47059B53 CRC64;
MSESIDFYDF ERLLDKAYEE LPENVKSHKS RFEVPPAVVT IAGNRTIIEN FVDIAEAMNR
DPSHLLKFIL REVATAGTLE GRRVILQGRF TPYLIANKLK KYLKEYVICP VCGSPDTKII
KRDRFYFLKC EACGAETPIQ HL