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IF2G_HALS3
ID   IF2G_HALS3              Reviewed;         414 AA.
AC   B0R6Y7;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Translation initiation factor 2 subunit gamma {ECO:0000255|HAMAP-Rule:MF_00119};
DE            EC=3.6.5.3 {ECO:0000255|HAMAP-Rule:MF_00119};
DE   AltName: Full=aIF2-gamma {ECO:0000255|HAMAP-Rule:MF_00119};
DE   AltName: Full=eIF-2-gamma {ECO:0000255|HAMAP-Rule:MF_00119};
GN   Name=eif2g {ECO:0000255|HAMAP-Rule:MF_00119}; OrderedLocusNames=OE_3876R;
OS   Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=478009;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29341 / DSM 671 / R1;
RX   PubMed=18313895; DOI=10.1016/j.ygeno.2008.01.001;
RA   Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA   Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT   "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT   R1 compared to that of strain NRC-1.";
RL   Genomics 91:335-346(2008).
CC   -!- FUNCTION: eIF-2 functions in the early steps of protein synthesis by
CC       forming a ternary complex with GTP and initiator tRNA.
CC       {ECO:0000255|HAMAP-Rule:MF_00119}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.3;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00119};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00119};
CC   -!- SUBUNIT: Heterotrimer composed of an alpha, a beta and a gamma chain.
CC       {ECO:0000255|HAMAP-Rule:MF_00119}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. EIF2G subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00119}.
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DR   EMBL; AM774415; CAP14506.1; -; Genomic_DNA.
DR   RefSeq; WP_010903512.1; NC_010364.1.
DR   AlphaFoldDB; B0R6Y7; -.
DR   SMR; B0R6Y7; -.
DR   EnsemblBacteria; CAP14506; CAP14506; OE_3876R.
DR   GeneID; 5953221; -.
DR   GeneID; 62887370; -.
DR   KEGG; hsl:OE_3876R; -.
DR   HOGENOM; CLU_027154_0_1_2; -.
DR   OMA; NIGMVGH; -.
DR   PhylomeDB; B0R6Y7; -.
DR   Proteomes; UP000001321; Chromosome.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   CDD; cd01888; eIF2_gamma; 1.
DR   CDD; cd15490; eIF2_gamma_III; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00119; eIF_2_gamma; 1.
DR   InterPro; IPR004161; EFTu-like_2.
DR   InterPro; IPR015256; eIF2g_C.
DR   InterPro; IPR044128; eIF2g_GTP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR022424; TIF2_gsu.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR   Pfam; PF09173; eIF2_C; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF03144; GTP_EFTU_D2; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   SUPFAM; SSF50465; SSF50465; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03680; eif2g_arch; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   GTP-binding; Hydrolase; Initiation factor; Magnesium; Metal-binding;
KW   Nucleotide-binding; Protein biosynthesis.
FT   CHAIN           1..414
FT                   /note="Translation initiation factor 2 subunit gamma"
FT                   /id="PRO_1000095097"
FT   DOMAIN          7..204
FT                   /note="tr-type G"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00119"
FT   REGION          16..23
FT                   /note="G1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00119"
FT   REGION          44..48
FT                   /note="G2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00119"
FT   REGION          91..94
FT                   /note="G3"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00119"
FT   REGION          147..150
FT                   /note="G4"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00119"
FT   REGION          182..184
FT                   /note="G5"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00119"
FT   BINDING         19..24
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00119"
FT   BINDING         19
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00119"
FT   BINDING         23
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00119"
FT   BINDING         44
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00119"
FT   BINDING         46
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00119"
FT   BINDING         147..150
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00119"
FT   BINDING         182..184
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00119"
SQ   SEQUENCE   414 AA;  43781 MW;  8729497CF020BD6D CRC64;
     MADEHRQPEV NIGLVGHVDH GKTTLVRALS GEWTDQHSEE MKRGISIRLG YADATLRRCP
     DCDEPECYTV AETCPEHDTA TEIERTVSFV DAPGHETLMA TMLSGAALMD GAVLVVGANE
     PVPQPQTEEH LMALDIIGIE NIVIAQNKVD LVDAEEARQN YEEIQAFVEG TVAEDAPVVP
     VSAEQEINVD LVIDALQTEI ATPDRDPSAD PLLYAARSFD INRPGTEWGG LLGGVIGGSL
     VDGELEAGDE LELRPGREVE EGGKTEWRPV TTDVRSLQAG GEDVDSASPG GLLGVGTGLD
     PSLTKGDALA GQVAGPPGSL PPTWESFEMD VDLLERLVGA ADGEQIDDIS TGEPLMLTVG
     TATTVGSVTS ARDGECEVAL KRPVCAPAGA KIAINRRVGA RWRLIGVGTL TESE
 
 
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