ID   IF2G_PIG                Reviewed;          22 AA.
AC   P20461;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   02-JUN-2021, entry version 54.
DE   RecName: Full=Eukaryotic translation initiation factor 2 subunit 3;
DE   AltName: Full=Eukaryotic translation initiation factor 2 subunit gamma;
DE            Short=eIF-2-gamma;
DE   Flags: Fragment;
GN   Name=EIF2S3; Synonyms=EIF2G;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Liver;
RA   Suzuki H., Mukouyama E.B.;
RT   "Pig liver translational initiation factor eIF-2: N-terminal amino acid
RT   sequences of alpha and gamma subunits and the phosphorylation site
RT   structure.";
RL   Agric. Biol. Chem. 52:1397-1408(1988).
CC   -!- FUNCTION: eIF-2 functions in the early steps of protein synthesis by
CC       forming a ternary complex with GTP and initiator tRNA. This complex
CC       binds to a 40S ribosomal subunit, followed by mRNA binding to form a
CC       43S preinitiation complex. Junction of the 60S ribosomal subunit to
CC       form the 80S initiation complex is preceded by hydrolysis of the GTP
CC       bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for
CC       eIF-2 to recycle and catalyze another round of initiation, the GDP
CC       bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by
CC       eIF-2B.
CC   -!- SUBUNIT: The eukaryotic translation initiation factor 2 complex/eIF2 is
CC       a heterotrimer composed of an alpha subunit, also called subunit 1
CC       (encoded by EIF2S1), a beta subunit, also called subunit 2 (encoded by
CC       EIF2S2) and a gamma subunit, also called subunit 3 (encoded by EIF2S3).
CC       {ECO:0000250|UniProtKB:P41091}.
CC   -!- SIMILARITY: Belongs to the GTP-binding elongation factor family. EIF2G
CC       subfamily. {ECO:0000305}.
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DR   PIR; PT0052; PT0052.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005850; C:eukaryotic translation initiation factor 2 complex; ISS:UniProtKB.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Acetylation; Direct protein sequencing; GTP-binding; Initiation factor;
KW   Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..>22
FT                   /note="Eukaryotic translation initiation factor 2 subunit
FT                   3"
FT                   /id="PRO_0000137441"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:P41091"
FT   NON_TER         22
SQ   SEQUENCE   22 AA;  2207 MW;  428B47D77D18B03C CRC64;
     AGTEAGVTLG QPSLXEQDSX XL