ID   APDR_EMENI              Reviewed;         730 AA.
AC   Q5ATG6; C8VEB5;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Aspyridones cluster regulator apdR {ECO:0000303|PubMed:17369821};
DE   AltName: Full=Aspyridones biosynthesis protein R {ECO:0000303|PubMed:17369821};
GN   Name=apdR {ECO:0000303|PubMed:17369821}; ORFNames=AN8414;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
RN   [3]
RP   FUNCTION.
RX   PubMed=17369821; DOI=10.1038/nchembio869;
RA   Bergmann S., Schuemann J., Scherlach K., Lange C., Brakhage A.A.,
RA   Hertweck C.;
RT   "Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus
RT   nidulans.";
RL   Nat. Chem. Biol. 3:213-217(2007).
CC   -!- FUNCTION: Transcription factor involved in regulation of gene cluster
CC       that mediates the biosynthesis of aspyridones (PubMed:17369821).
CC       {ECO:0000269|PubMed:17369821}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; BN001305; CBF80491.1; -; Genomic_DNA.
DR   EMBL; AACD01000153; EAA67036.1; -; Genomic_DNA.
DR   RefSeq; XP_681683.1; XM_676591.1.
DR   AlphaFoldDB; Q5ATG6; -.
DR   SMR; Q5ATG6; -.
DR   EnsemblFungi; CBF80491; CBF80491; ANIA_08414.
DR   EnsemblFungi; EAA67036; EAA67036; AN8414.2.
DR   GeneID; 2868839; -.
DR   KEGG; ani:AN8414.2; -.
DR   eggNOG; ENOG502RZYM; Eukaryota.
DR   HOGENOM; CLU_007091_4_0_1; -.
DR   InParanoid; Q5ATG6; -.
DR   OMA; QWHAILA; -.
DR   OrthoDB; 999364at2759; -.
DR   Proteomes; UP000000560; Chromosome V.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..730
FT                   /note="Aspyridones cluster regulator apdR"
FT                   /id="PRO_0000438457"
FT   DNA_BIND        20..46
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
SQ   SEQUENCE   730 AA;  81802 MW;  ABA646557C674404 CRC64;
     MHVDSRGNAP VRRRRPAVAC TECRRRKIRC DQATPCRHCE KAALRCIYNH LRPNTSQSKI
     SPPTSASGFI SGSQLSVNDS PQLPLSNDTK FHGFGSGSLK SDLSLEYVPS ALPTSSSIFV
     EPNSLSSLSE PLAWEIAPPE TGVGILAESD SPLNMQGQTG ELRDQHTAPW MEILHCDPDE
     FWFDSEELRR MWRKTRDLEL LLATSKMPSE WLYWSPGPTA PEASSLIPPR ATCDVLLELQ
     YWSSPDSMSD VFLCKLLLAM AIGTLFAPAS PSAGQLTDMR PRALAWMHYG QQWLFRKIVL
     DAQLNLDILQ TSPTSIGDRH FWLSEDCLVR MAMKLGLHRD PHIHNPAMLG TEVEVRRRLW
     VTLLELSLQA SLDAKLPVPL PSDGGFDTEL PSNLSDTDLG SIATLCNPNP RTFFTHSTMQ
     ILLAETQRIR IRILNLLYSP ATSIPYQEAL KLASELRRAC NTNLRLLQSF TPQTPGAMMP
     TEFQTKILDL WTRRFLLALL TPYADEARSD YSLYYTRKAR IDASSLLLSY PLSHSTATGP
     SPIGSYYLQL QISGQGIFRN VLKQATAAIC QDLIQELVED AFPVTDREPH AKLCQIIRDS
     ISIYRTRMEL SQPCMQEYVA FVCASAQIGA LRSRCDNKHD FFPTAKKALG QCHHILESNH
     RSNSPEKYRA ETMHVLDIDQ GMNFWSDLLS TAGASPLSPP SSSSFFLEHG LSHTVPWEAP
     HSREVVDNER