ID   APD_DOLMA               Reviewed;          17 AA.
AC   C0HKX5;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2017, sequence version 1.
DT   25-MAY-2022, entry version 5.
DE   RecName: Full=Apidaecin Ho + {ECO:0000303|PubMed:7929322};
OS   Dolichovespula maculata (Bald-faced hornet) (Vespula maculata).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Vespinae; Dolichovespula.
OX   NCBI_TaxID=7441 {ECO:0000303|PubMed:7929322};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, INDUCTION, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Hemolymph {ECO:0000303|PubMed:7929322};
RX   PubMed=7929322; DOI=10.1016/s0021-9258(18)47165-7;
RA   Casteels P., Romagnolo J., Castle M., Casteels-Josson K.,
RA   Erdjument-Bromage H., Tempst P.;
RT   "Biodiversity of apidaecin-type peptide antibiotics. Prospects of
RT   manipulating the antibacterial spectrum and combating acquired
RT   resistance.";
RL   J. Biol. Chem. 269:26107-26115(1994).
CC   -!- FUNCTION: Antimicrobial peptide active against many Gram-negative
CC       enterobacterial and plant-associated bacterial species. Not active
CC       against other bacterial species like H.pylori, P.mirabilis, B.pertussis
CC       or N.gonorrhoeae. {ECO:0000269|PubMed:7929322}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7929322}.
CC   -!- INDUCTION: By bacterial infection. {ECO:0000269|PubMed:7929322}.
CC   -!- MASS SPECTROMETRY: Mass=1960.0; Method=MALDI; Note=Apidaecin Ho +.;
CC       Evidence={ECO:0000269|PubMed:7929322};
CC   -!- SIMILARITY: Belongs to the apidaecin family. {ECO:0000305}.
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DR   AlphaFoldDB; C0HKX5; -.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Immunity;
KW   Innate immunity; Secreted.
FT   PEPTIDE         1..17
FT                   /note="Apidaecin Ho +"
FT                   /evidence="ECO:0000269|PubMed:7929322"
FT                   /id="PRO_0000441345"
SQ   SEQUENCE   17 AA;  1957 MW;  BBAA8D70E720AB5F CRC64;
     GKPRPQQVPP RPPHPRL