APD_VESMC
ID APD_VESMC Reviewed; 18 AA.
AC C0HKX4;
DT 30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2017, sequence version 1.
DT 25-MAY-2022, entry version 5.
DE RecName: Full=Apidaecin Yj +S {ECO:0000303|PubMed:7929322};
DE Contains:
DE RecName: Full=Apidaecin Yj -S {ECO:0000303|PubMed:7929322};
OS Vespula maculifrons (Eastern yellow jacket) (Wasp).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC Vespidae; Vespinae; Vespula.
OX NCBI_TaxID=7453 {ECO:0000303|PubMed:7929322};
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, INDUCTION, AND MASS
RP SPECTROMETRY.
RC TISSUE=Hemolymph {ECO:0000303|PubMed:7929322};
RX PubMed=7929322; DOI=10.1016/s0021-9258(18)47165-7;
RA Casteels P., Romagnolo J., Castle M., Casteels-Josson K.,
RA Erdjument-Bromage H., Tempst P.;
RT "Biodiversity of apidaecin-type peptide antibiotics. Prospects of
RT manipulating the antibacterial spectrum and combating acquired
RT resistance.";
RL J. Biol. Chem. 269:26107-26115(1994).
CC -!- FUNCTION: Antimicrobial peptide active against many Gram-negative
CC enterobacterial and plant-associated bacterial species. Not active
CC against other bacterial species like H.pylori, P.mirabilis, B.pertussis
CC or N.gonorrhoeae. {ECO:0000269|PubMed:7929322}.
CC -!- FUNCTION: [Apidaecin Yj +S]: Not active against Y.enterolytica or
CC A.tumefaciens. {ECO:0000269|PubMed:7929322}.
CC -!- FUNCTION: [Apidaecin Yj -S]: Among others, also active against
CC Y.enterolytica and A.tumefaciens. {ECO:0000269|PubMed:7929322}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7929322}.
CC -!- INDUCTION: By bacterial infection. {ECO:0000269|PubMed:7929322}.
CC -!- MASS SPECTROMETRY: [Apidaecin Yj +S]: Mass=2102.9; Method=MALDI;
CC Note=Apidaecin Yj +S.; Evidence={ECO:0000269|PubMed:7929322};
CC -!- MASS SPECTROMETRY: [Apidaecin Yj -S]: Mass=2015.8; Method=MALDI;
CC Note=Apidaecin Yj - S.; Evidence={ECO:0000269|PubMed:7929322};
CC -!- SIMILARITY: Belongs to the apidaecin family. {ECO:0000305}.
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DR AlphaFoldDB; C0HKX4; -.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Direct protein sequencing; Immunity;
KW Innate immunity; Secreted.
FT PEPTIDE 1..18
FT /note="Apidaecin Yj +S"
FT /evidence="ECO:0000269|PubMed:7929322"
FT /id="PRO_0000441343"
FT PEPTIDE 2..18
FT /note="Apidaecin Yj -S"
FT /evidence="ECO:0000269|PubMed:7929322"
FT /id="PRO_0000441344"
SQ SEQUENCE 18 AA; 2101 MW; B4C37BE0E720AB5F CRC64;
SNKPRPQQVP PRPPHPRL