ID   IF2P_PYRAR              Reviewed;         592 AA.
AC   A4WIK2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Probable translation initiation factor IF-2 {ECO:0000255|HAMAP-Rule:MF_00100};
GN   Name=infB {ECO:0000255|HAMAP-Rule:MF_00100}; OrderedLocusNames=Pars_0628;
OS   Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6).
OC   Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC   Pyrobaculum.
OX   NCBI_TaxID=340102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700994 / DSM 13514 / JCM 11321 / PZ6;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Cozen A.E.,
RA   Fitz-Gibbon S.T., House C.H., Saltikov C., Lowe T.M., Richardson P.;
RT   "Complete sequence of Pyrobaculum arsenaticum DSM 13514.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Function in general translation initiation by promoting the
CC       binding of the formylmethionine-tRNA to ribosomes. Seems to function
CC       along with eIF-2. {ECO:0000255|HAMAP-Rule:MF_00100}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00100}.
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DR   EMBL; CP000660; ABP50219.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4WIK2; -.
DR   SMR; A4WIK2; -.
DR   STRING; 340102.Pars_0628; -.
DR   EnsemblBacteria; ABP50219; ABP50219; Pars_0628.
DR   KEGG; pas:Pars_0628; -.
DR   HOGENOM; CLU_002656_3_3_2; -.
DR   OMA; FRQSKPA; -.
DR   PhylomeDB; A4WIK2; -.
DR   Proteomes; UP000001567; Chromosome.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.10050; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00100_A; IF_2_A; 1.
DR   InterPro; IPR004161; EFTu-like_2.
DR   InterPro; IPR029459; EFTU-type.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR004544; TF_aIF-2_arc.
DR   InterPro; IPR015760; TIF_IF2.
DR   InterPro; IPR023115; TIF_IF2_dom3.
DR   InterPro; IPR036925; TIF_IF2_dom3_sf.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   PANTHER; PTHR43381; PTHR43381; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF03144; GTP_EFTU_D2; 1.
DR   Pfam; PF14578; GTP_EFTU_D4; 1.
DR   Pfam; PF11987; IF-2; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   SUPFAM; SSF52156; SSF52156; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00491; aIF-2; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   GTP-binding; Initiation factor; Nucleotide-binding; Protein biosynthesis.
FT   CHAIN           1..592
FT                   /note="Probable translation initiation factor IF-2"
FT                   /id="PRO_0000335532"
FT   DOMAIN          4..225
FT                   /note="tr-type G"
FT   REGION          13..20
FT                   /note="G1"
FT                   /evidence="ECO:0000250"
FT   REGION          38..42
FT                   /note="G2"
FT                   /evidence="ECO:0000250"
FT   REGION          79..82
FT                   /note="G3"
FT                   /evidence="ECO:0000250"
FT   REGION          133..136
FT                   /note="G4"
FT                   /evidence="ECO:0000250"
FT   REGION          201..203
FT                   /note="G5"
FT                   /evidence="ECO:0000250"
FT   BINDING         13..20
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
FT   BINDING         79..83
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
FT   BINDING         133..136
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
SQ   SEQUENCE   592 AA;  65538 MW;  8F2A870456649E98 CRC64;
     MAGVRSPFVV VMGHVDVGKT LLLDKIRGTS VAYREPGMIT QHIGMSFVPW QAVEKFSGPL
     VDRLRLRGRI WIPGFLFIDT PGHAAFSNLR KRGGSVADLA ILVVDITSGL EDQGVESLKL
     IQSRGVPFVI AANKLDRIYG WKSVENRPFL FAVEDQEWHA VATLEERIGK LIEELSKFGI
     EADRYDRVRD FTKQVPIVPT SAVTGEGIAD LLLVLAGVSQ RFIPKEKLQV GEGPARGVVM
     EVKEERGLGV VADAIIYDGR LRKGDVVVTA GLEGPKEAKV RMLIMPKPLE EMRDPEDRFM
     AVEEVKAAAG VRIVADGLEG VVAGAPLLAV WSLQDLPNAR RLVGEEISEI KIESDREGVI
     VRADTFGTLE STVLFLRQQG VPVRKADVGP PTHKDVVEAV LSRRKNPAFG VILAFNVKIP
     PDVEKEATSS GIKIIRGEIL YRIFDEYLKW SQEVKTKTIE QILSQLTRPG KIQILPGFVF
     RRSDPVIVGV KVLAGTIKPG VTLVKDGREV GKIMQIQKQG KPVNEAAVGD EVAISIQGDV
     MVGRQIKEGD VLYVYVPDEQ AREWLFKYKQ YLRDDEKKAL EEFLKTRKSA HQ