IF2P_STAMF
ID IF2P_STAMF Reviewed; 606 AA.
AC A3DMS0;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Probable translation initiation factor IF-2 {ECO:0000255|HAMAP-Rule:MF_00100};
GN Name=infB {ECO:0000255|HAMAP-Rule:MF_00100}; OrderedLocusNames=Smar_0829;
OS Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1).
OC Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC Desulfurococcaceae; Staphylothermus.
OX NCBI_TaxID=399550;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43588 / DSM 3639 / JCM 9404 / F1;
RX PubMed=19341479; DOI=10.1186/1471-2164-10-145;
RA Anderson I.J., Dharmarajan L., Rodriguez J., Hooper S., Porat I.,
RA Ulrich L.E., Elkins J.G., Mavromatis K., Sun H., Land M., Lapidus A.,
RA Lucas S., Barry K., Huber H., Zhulin I.B., Whitman W.B., Mukhopadhyay B.,
RA Woese C., Bristow J., Kyrpides N.;
RT "The complete genome sequence of Staphylothermus marinus reveals
RT differences in sulfur metabolism among heterotrophic Crenarchaeota.";
RL BMC Genomics 10:145-145(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43588 / DSM 3639 / JCM 9404 / F1;
RX PubMed=21304655; DOI=10.4056/sigs.30527;
RA Anderson I.J., Sun H., Lapidus A., Copeland A., Glavina Del Rio T.,
RA Tice H., Dalin E., Lucas S., Barry K., Land M., Richardson P., Huber H.,
RA Kyrpides N.C.;
RT "Complete genome sequence of Staphylothermus marinus Stetter and Fiala 1986
RT type strain F1.";
RL Stand. Genomic Sci. 1:183-188(2009).
CC -!- FUNCTION: Function in general translation initiation by promoting the
CC binding of the formylmethionine-tRNA to ribosomes. Seems to function
CC along with eIF-2. {ECO:0000255|HAMAP-Rule:MF_00100}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_00100}.
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DR EMBL; CP000575; ABN69930.1; -; Genomic_DNA.
DR RefSeq; WP_011839121.1; NC_009033.1.
DR AlphaFoldDB; A3DMS0; -.
DR SMR; A3DMS0; -.
DR STRING; 399550.Smar_0829; -.
DR EnsemblBacteria; ABN69930; ABN69930; Smar_0829.
DR GeneID; 4907893; -.
DR KEGG; smr:Smar_0829; -.
DR eggNOG; arCOG01560; Archaea.
DR HOGENOM; CLU_002656_3_3_2; -.
DR OMA; FRQSKPA; -.
DR OrthoDB; 17053at2157; -.
DR Proteomes; UP000000254; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.10050; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00100_A; IF_2_A; 1.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR029459; EFTU-type.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR004544; TF_aIF-2_arc.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR PANTHER; PTHR43381; PTHR43381; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF14578; GTP_EFTU_D4; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50447; SSF50447; 1.
DR SUPFAM; SSF52156; SSF52156; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00491; aIF-2; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW GTP-binding; Initiation factor; Nucleotide-binding; Protein biosynthesis;
KW Reference proteome.
FT CHAIN 1..606
FT /note="Probable translation initiation factor IF-2"
FT /id="PRO_0000335535"
FT DOMAIN 11..230
FT /note="tr-type G"
FT REGION 20..27
FT /note="G1"
FT /evidence="ECO:0000250"
FT REGION 45..49
FT /note="G2"
FT /evidence="ECO:0000250"
FT REGION 85..88
FT /note="G3"
FT /evidence="ECO:0000250"
FT REGION 139..142
FT /note="G4"
FT /evidence="ECO:0000250"
FT REGION 207..209
FT /note="G5"
FT /evidence="ECO:0000250"
FT BINDING 20..27
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
FT BINDING 85..89
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
FT BINDING 139..142
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
SQ SEQUENCE 606 AA; 67873 MW; E253A2813D53BA57 CRC64;
MSSVKSGKSW IRQPIVVVLG HVDHGKTTLL DKIRGTAVAK KEPGEITQHV GASIVPASVL
RKVAEPLKKY FPKLKIEIPG LLFVDTPGHE LFSNLRRRGG SVADIAILVV DIMEGFQPQT
WESIQILKER KVPFIVAANK IDRIPGWKPN HDQPFLETIR KQDPRIVSRL EELIYRLISQ
LYEAGFMAER FDRVKDFRTT VAIVPVSAKT GEGVPELLAL LTGLVQRFMK KRLVTSEEPA
KGVVLEVKEE PGLGTTIDVI IYDGVIRRGD TIVVGGKDKP IVTKVRALLM PRPLQDMRAH
EGKFVSVEQV VAATGVKISA PDLDNALAGS PIFVVPSEDK IEEYIKIVKE EIESVRIKTD
NIGVVVKADT LGTLEAVVEA LKRENIPVRL ADVGPVSKND VLEASVSKNH RPEYGVIIAF
NVKILPEAEE YAARENVKIF RHNVIYKLIE DYIGWVKQLR EQEKIKELES LIRPGKIRIL
PGYIFRRSNP AIVGVEVIGG VIKPGYPLMR KDGMRLGTIM QIRDRDNVLK EARAGQSVAI
SIRGRILVGR HVDEGDILYT DIPKQHVHLW LTKYKNELSD DEKMVLKEII EIKKKQDPFY
GLVFGS
