ID   IF2P_THEAC              Reviewed;         589 AA.
AC   Q9HJ60;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Probable translation initiation factor IF-2;
GN   Name=infB; OrderedLocusNames=Ta1112;
OS   Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS   15155 / AMRC-C165).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273075;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RX   PubMed=11029001; DOI=10.1038/35035069;
RA   Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C.,
RA   Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT   "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT   acidophilum.";
RL   Nature 407:508-513(2000).
CC   -!- FUNCTION: Function in general translation initiation by promoting the
CC       binding of the formylmethionine-tRNA to ribosomes. Seems to function
CC       along with eIF-2 (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL445066; CAC12239.1; -; Genomic_DNA.
DR   RefSeq; WP_010901522.1; NC_002578.1.
DR   AlphaFoldDB; Q9HJ60; -.
DR   SMR; Q9HJ60; -.
DR   STRING; 273075.Ta1112; -.
DR   EnsemblBacteria; CAC12239; CAC12239; CAC12239.
DR   GeneID; 1456621; -.
DR   KEGG; tac:Ta1112; -.
DR   eggNOG; arCOG01560; Archaea.
DR   HOGENOM; CLU_002656_3_3_2; -.
DR   OMA; FRQSKPA; -.
DR   OrthoDB; 17053at2157; -.
DR   Proteomes; UP000001024; Chromosome.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.10050; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00100_A; IF_2_A; 1.
DR   InterPro; IPR029459; EFTU-type.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR004544; TF_aIF-2_arc.
DR   InterPro; IPR015760; TIF_IF2.
DR   InterPro; IPR023115; TIF_IF2_dom3.
DR   InterPro; IPR036925; TIF_IF2_dom3_sf.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   PANTHER; PTHR43381; PTHR43381; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF14578; GTP_EFTU_D4; 1.
DR   Pfam; PF11987; IF-2; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   SUPFAM; SSF52156; SSF52156; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00491; aIF-2; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   GTP-binding; Initiation factor; Nucleotide-binding; Protein biosynthesis;
KW   Reference proteome.
FT   CHAIN           1..589
FT                   /note="Probable translation initiation factor IF-2"
FT                   /id="PRO_0000137310"
FT   DOMAIN          14..229
FT                   /note="tr-type G"
FT   REGION          23..30
FT                   /note="G1"
FT                   /evidence="ECO:0000250"
FT   REGION          48..52
FT                   /note="G2"
FT                   /evidence="ECO:0000250"
FT   REGION          84..87
FT                   /note="G3"
FT                   /evidence="ECO:0000250"
FT   REGION          138..141
FT                   /note="G4"
FT                   /evidence="ECO:0000250"
FT   REGION          206..208
FT                   /note="G5"
FT                   /evidence="ECO:0000250"
FT   BINDING         23..30
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         84..88
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         138..141
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   589 AA;  65386 MW;  28273B799F1D1A84 CRC64;
     MATKSSTSQA VSKLRQPIVC VLGHVDHGKT TLLDLIRGTS VASKEPGGIT QRIAATTVDI
     SRILKETEKL NTKGLKIPGL LFIDTPGHVA FSNMRARGGA LADLAILVID INEGIMPQTV
     ESIDILKKFK TPFIIAANKI DLIPFFTDVK TNLFTEFIRK QRQEYVNELD NRIYSIMNKL
     YEFGLNSDRF DRISDFTKTI AIVPVSAKKN IGVPEILMVL AGLAQRFLER EIEYRDINGH
     ATIIEVRKEE SAGITLDAVL YQGTISVGDS IAVNTKNGPA VTKVKALFVN TGKGQRALKE
     VKKVSAAEGI RVLISDKIDV ISGSPMIVVR DNLDQVMKEI EEESKVDIPL SEEGIYVKAE
     AIGSLEAISY ELNKQGIKIK QAQVGDITKR DIMDVSTLPD PINRIIVGFN VSVLPEARDA
     MSSSDVSIVT GDIIYKIVED TQKVMDERKK MLLQGRKMSM PVPSRIRILP QYIFRASKPV
     IVGVRVETGQ IKVGDNLIRG DGKYAGTIKS IRNEDVSVRY QDAPAEVAVA IDNVTLNRQI
     FPDDVLYVDI TENVVKELRR APMEKEIMDT LEEIIRIKRK DNPFWGTRV