ID   IF2P_THEVO              Reviewed;         589 AA.
AC   Q97BK4;
DT   05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Probable translation initiation factor IF-2 {ECO:0000255|HAMAP-Rule:MF_00100};
GN   Name=infB {ECO:0000255|HAMAP-Rule:MF_00100}; OrderedLocusNames=TV0451;
GN   ORFNames=TVG0440169;
OS   Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC
OS   15438 / GSS1).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1;
RX   PubMed=11121031; DOI=10.1073/pnas.97.26.14257;
RA   Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y.,
RA   Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T.,
RA   Yamamoto Y., Aramaki H., Makino K., Suzuki M.;
RT   "Archaeal adaptation to higher temperatures revealed by genomic sequence of
RT   Thermoplasma volcanium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000).
CC   -!- FUNCTION: Function in general translation initiation by promoting the
CC       binding of the formylmethionine-tRNA to ribosomes. Seems to function
CC       along with eIF-2. {ECO:0000255|HAMAP-Rule:MF_00100}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00100}.
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DR   EMBL; BA000011; BAB59593.1; -; Genomic_DNA.
DR   RefSeq; WP_010916711.1; NC_002689.2.
DR   AlphaFoldDB; Q97BK4; -.
DR   SMR; Q97BK4; -.
DR   STRING; 273116.14324666; -.
DR   EnsemblBacteria; BAB59593; BAB59593; BAB59593.
DR   GeneID; 1440969; -.
DR   KEGG; tvo:TVG0440169; -.
DR   eggNOG; arCOG01560; Archaea.
DR   HOGENOM; CLU_002656_3_3_2; -.
DR   OMA; FRQSKPA; -.
DR   OrthoDB; 17053at2157; -.
DR   PhylomeDB; Q97BK4; -.
DR   Proteomes; UP000001017; Chromosome.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.10050; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00100_A; IF_2_A; 1.
DR   InterPro; IPR029459; EFTU-type.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR004544; TF_aIF-2_arc.
DR   InterPro; IPR015760; TIF_IF2.
DR   InterPro; IPR023115; TIF_IF2_dom3.
DR   InterPro; IPR036925; TIF_IF2_dom3_sf.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   PANTHER; PTHR43381; PTHR43381; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF14578; GTP_EFTU_D4; 1.
DR   Pfam; PF11987; IF-2; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   SUPFAM; SSF52156; SSF52156; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00491; aIF-2; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   GTP-binding; Initiation factor; Nucleotide-binding; Protein biosynthesis.
FT   CHAIN           1..589
FT                   /note="Probable translation initiation factor IF-2"
FT                   /id="PRO_0000137311"
FT   DOMAIN          14..231
FT                   /note="tr-type G"
FT   REGION          23..30
FT                   /note="G1"
FT                   /evidence="ECO:0000250"
FT   REGION          48..52
FT                   /note="G2"
FT                   /evidence="ECO:0000250"
FT   REGION          84..87
FT                   /note="G3"
FT                   /evidence="ECO:0000250"
FT   REGION          138..141
FT                   /note="G4"
FT                   /evidence="ECO:0000250"
FT   REGION          206..208
FT                   /note="G5"
FT                   /evidence="ECO:0000250"
FT   BINDING         23..30
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
FT   BINDING         84..88
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
FT   BINDING         138..141
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
SQ   SEQUENCE   589 AA;  65198 MW;  0C4CDC1C30820573 CRC64;
     METKSSTSLP AKKLRQPIVC VLGHVDHGKT TLLDIIRGTA VANKEPGGIT QRIAATTVDI
     NKILKATEKL NNKGMKIPGL LFIDTPGHVA FSNMRARGGA LADIAVLVID INEGIMPQTV
     ESIDILKKFK TPFIIAANKI DLIPFFTDVK TNLFTEFIRK QRQEYVNELD ARIYNIVNKL
     YEYGLNSDRF DRISDFTKTI AIVPVSAKKN IGVPEILMVL AGLAQRFLES EIEYKDINGH
     ATIIEVRREE SAGIALDAVL YQGTISVGDT VAVNTKTGPV TTKVKALFVN TGKSQRSLKE
     VETVSAAEGI RVLISDKLDV ISGSPLIVVK GNMEQVMKEI EEASKVDIPL DENGIYVKAE
     AIGSLEAISY ELNKQGIKIR AAAVGDITKR DVMDVQTLQD PLNRIIIGFN VSILPEAKDA
     IESSDVGVIT GDIIYKIVED TQKWIEERKK QLSQKRKEAM PVPAKIRILP QYIFRASKPV
     IVGIRVETGQ IKVGDNLIRS DGKYAGTIKS IRNDEVSVRY QDAPAEVAVA IDNVTLNRQI
     FPDDVLYVDI PESVVKELRK APMEKEIMDT LEEIIKIKRK ENPFWGTKV