ID   APE2_AERPE              Reviewed;         167 AA.
AC   O73943; Q9YAM2;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Homing endonuclease I-ApeII;
DE            EC=3.1.-.-;
DE   AltName: Full=rRNA intron-encoded homing endonuclease 2;
GN   Name=apeII; OrderedLocusNames=APE_1921;
OS   Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 /
OS   K1).
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=272557;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX   PubMed=9658008; DOI=10.1128/jb.180.14.3635-3643.1998;
RA   Nomura N., Sako Y., Uchida A.;
RT   "Molecular characterization and postsplicing fate of three introns within
RT   the single rRNA operon of the hyperthermophilic archaeon Aeropyrum pernix
RT   K1.";
RL   J. Bacteriol. 180:3635-3643(1998).
RN   [2]
RP   SEQUENCE REVISION.
RA   Nomura N.;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX   PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K.,
RA   Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A.,
RA   Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S.,
RA   Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA   Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
RT   "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,
RT   Aeropyrum pernix K1.";
RL   DNA Res. 6:83-101(1999).
CC   -!- FUNCTION: Endonuclease involved in rRNA intron I-gamma homing.
CC   -!- SIMILARITY: Belongs to the LAGLIDADG endonuclease family.
CC       {ECO:0000305}.
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DR   EMBL; AB008745; BAA31988.2; -; Genomic_DNA.
DR   EMBL; BA000002; BAA80926.1; -; Genomic_DNA.
DR   PIR; A72580; A72580.
DR   AlphaFoldDB; O73943; -.
DR   SMR; O73943; -.
DR   EnsemblBacteria; BAA80926; BAA80926; APE_1921.
DR   KEGG; ape:APE_1921; -.
DR   eggNOG; arCOG08947; Archaea.
DR   OMA; RRVECCV; -.
DR   Proteomes; UP000002518; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006314; P:intron homing; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.28.10; -; 1.
DR   InterPro; IPR027434; Homing_endonucl.
DR   InterPro; IPR004860; LAGLIDADG_2.
DR   Pfam; PF00961; LAGLIDADG_1; 1.
DR   SUPFAM; SSF55608; SSF55608; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Intron homing; Nuclease; Reference proteome.
FT   CHAIN           1..167
FT                   /note="Homing endonuclease I-ApeII"
FT                   /id="PRO_0000192790"
SQ   SEQUENCE   167 AA;  19141 MW;  52D500B57FBC75CB CRC64;
     MDQCLLEGYV AGIIDAEASL SVSIKIQEDL RCRVRVDPVF SITQDSKDVL NVVKNYFGCG
     RLMPKPGQEH LTLYVVDRLE ALADCLIPKL DRLPLIVKKR GFEMFREIVL TLTRMKYRRV
     ECCVIRDLVL KSYSLSSLNK KSKRKRSLEE ILKIIPCDKA VEPPGER