IF2_CAMC1
ID IF2_CAMC1 Reviewed; 885 AA.
AC A7ZC69;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Translation initiation factor IF-2 {ECO:0000255|HAMAP-Rule:MF_00100};
GN Name=infB {ECO:0000255|HAMAP-Rule:MF_00100};
GN OrderedLocusNames=Ccon26_04760; ORFNames=CCC13826_1495;
OS Campylobacter concisus (strain 13826).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Campylobacteraceae; Campylobacter.
OX NCBI_TaxID=360104;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=13826;
RA Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G.,
RA Mandrell R.E., On S., Nelson K.E.;
RT "Genome sequence of Campylobacter concisus 13826 isolated from human
RT feces.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: One of the essential components for the initiation of protein
CC synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis
CC and promotes its binding to the 30S ribosomal subunits. Also involved
CC in the hydrolysis of GTP during the formation of the 70S ribosomal
CC complex. {ECO:0000255|HAMAP-Rule:MF_00100}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00100}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_00100}.
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DR EMBL; CP000792; EAT99040.1; -; Genomic_DNA.
DR RefSeq; WP_012001357.1; NC_009802.2.
DR AlphaFoldDB; A7ZC69; -.
DR SMR; A7ZC69; -.
DR STRING; 360104.CCC13826_1495; -.
DR EnsemblBacteria; EAT99040; EAT99040; CCC13826_1495.
DR KEGG; cco:CCC13826_1495; -.
DR eggNOG; COG0532; Bacteria.
DR HOGENOM; CLU_006301_4_1_7; -.
DR OMA; NRDNRTG; -.
DR OrthoDB; 347113at2; -.
DR Proteomes; UP000001121; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd03702; IF2_mtIF2_II; 1.
DR Gene3D; 3.40.50.10050; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00100_B; IF_2_B; 1.
DR InterPro; IPR044145; IF2_II.
DR InterPro; IPR006847; IF2_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR000178; TF_IF2_bacterial-like.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR PANTHER; PTHR43381; PTHR43381; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF11987; IF-2; 1.
DR Pfam; PF04760; IF2_N; 2.
DR SUPFAM; SSF50447; SSF50447; 2.
DR SUPFAM; SSF52156; SSF52156; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00487; IF-2; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51722; G_TR_2; 1.
DR PROSITE; PS01176; IF2; 1.
PE 3: Inferred from homology;
KW Cytoplasm; GTP-binding; Initiation factor; Nucleotide-binding;
KW Protein biosynthesis.
FT CHAIN 1..885
FT /note="Translation initiation factor IF-2"
FT /id="PRO_1000008219"
FT DOMAIN 384..553
FT /note="tr-type G"
FT REGION 55..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..400
FT /note="G1"
FT /evidence="ECO:0000250"
FT REGION 418..422
FT /note="G2"
FT /evidence="ECO:0000250"
FT REGION 439..442
FT /note="G3"
FT /evidence="ECO:0000250"
FT REGION 493..496
FT /note="G4"
FT /evidence="ECO:0000250"
FT REGION 529..531
FT /note="G5"
FT /evidence="ECO:0000250"
FT BINDING 393..400
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
FT BINDING 439..443
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
FT BINDING 493..496
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
SQ SEQUENCE 885 AA; 96941 MW; 8A1AADE7F6978261 CRC64;
MSNVRISEIA NELGYPSKEI VEKAQELGLK VKTHSNAVSL EEAEAIYEYV QTGVIPDKFK
KKKSEPKAKK EPKKETEKEP AKKEEKPKTE PKKAATKAEP KPEKAKAEPK KEAQISEEKP
KTEPKKEEPV KVEQKPAEAP KPKESLADVT QKRRGLVIVK KKKDYEAPAP IKEEKKAEAA
VTNISDFKSM FSASDENLAR KKKKEKKVTV VSKKDSAEKM DLLGGSDFGD IVLEDEDVVV
LPDFSFKTPA PTPMQRTKQP NAMKTTVNNT INSFGEGGIQ RRARKKHKKP ENKQNSEAVT
SINIPKEIRV YEFAEKLNKQ PSEVIGKLFM LGMMTTKNDF LDEDAIEILA DEFNVEVNII
DDQKEFDYVA AYEEEIKDDE NLQPRAPVIT IMGHVDHGKT SLLDYIRKSR VAAGEAGGIT
QHVGAYMVNK NGRNITFIDT PGHEAFTAMR ARGAGVTDIV IIVVAADDGV KPQTKEAVSH
AKAAGVPIII AINKMDKESA NPDLVKTGLA ELDIMPTEWG GKYEFVPISA KTGMGIDDLL
EIVLLQADLL ELKANPKANA KATVIESSLQ KGRGPVATII VENGTLHVGD TVVAGVAYGK
IRSLLDDQGR SLREIKPGEC GVIVGLSEIA EAGETLIGVK TDKEAREYAQ KKAEYIRQKE
LSKSTKVSID ELSAKIAEGE LKTLPVIIKA DVGGSLEALK ASLEKLANDE IRVNVIHSGV
GGITQSDVAL ASASNDCIIL GFNIRPTGEI KEKAKESGVE IKTYNVIYNL IDDVKAILGG
LMSPIIREEQ LGQAQVRQVI HVPKVGTIAG CIVTEGTINR GAKIRLIREG VVVYEGLVSS
LKRFKDDVKE VAKGYECGVG IENFNDIREN DYIESFKEVK EKATL
