ID   APEB_MYCLE              Reviewed;         426 AA.
AC   Q50022; O08111;
DT   24-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   24-OCT-2001, sequence version 2.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Probable M18 family aminopeptidase 2;
DE            EC=3.4.11.-;
GN   Name=apeB; Synonyms=pepC, pepX; OrderedLocusNames=ML2213;
GN   ORFNames=MLCB5.29;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Smith D.R., Robison K.;
RL   Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the peptidase M18 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA62998.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAB08404.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAC31168.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U15182; AAA62998.1; ALT_INIT; Genomic_DNA.
DR   EMBL; Z95151; CAB08404.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL583924; CAC31168.1; ALT_INIT; Genomic_DNA.
DR   PIR; H87185; H87185.
DR   AlphaFoldDB; Q50022; -.
DR   SMR; Q50022; -.
DR   EnsemblBacteria; CAC31168; CAC31168; CAC31168.
DR   KEGG; mle:ML2213; -.
DR   Leproma; ML2213; -.
DR   eggNOG; COG1362; Bacteria.
DR   HOGENOM; CLU_019532_2_0_11; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.30.250.10; -; 1.
DR   HAMAP; MF_00467; Aminopeptidase_M18_2; 1.
DR   InterPro; IPR022984; M18_aminopeptidase_2.
DR   InterPro; IPR001948; Peptidase_M18.
DR   InterPro; IPR023358; Peptidase_M18_dom2.
DR   PANTHER; PTHR28570; PTHR28570; 1.
DR   Pfam; PF02127; Peptidase_M18; 1.
DR   PRINTS; PR00932; AMINO1PTASE.
PE   3: Inferred from homology;
KW   Aminopeptidase; Hydrolase; Metal-binding; Metalloprotease; Protease;
KW   Reference proteome; Zinc.
FT   CHAIN           1..426
FT                   /note="Probable M18 family aminopeptidase 2"
FT                   /id="PRO_0000173463"
FT   BINDING         79
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255"
FT   BINDING         156
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255"
FT   BINDING         399
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   426 AA;  45594 MW;  582ADDD29C3A0A53 CRC64;
     MPASAADLCE FINASPSPFH VCATVAGRLL DAGYAELSEV ERWPDHPGRY FIVRAGSLVA
     WSAGQGVKAH APFRIVGAHT DSPNLRVKQH PDLLVAGWRV VALQPYGGAW LNSWLDRDLG
     VSGRLSVRSA GKGSEITDRL VRIDDPILRV PQLAIHLAED RKSLTLDPQR HVNAVWGVGD
     KAGSLLEYVA ERTGVAVADV LAVDLMTHDL VPSMVIGADA NLLSAPRLDN QVSCYAGMEA
     LLASVPHDCL PVLALFDHEE VGSTSDRGAR SNLLSTVLER IVLAAGGGRD DYLRRLPASL
     LVSADMAHAT HPNYPECHEP SHLIEVNAGP VLKVHPNLRY ATDGRTAAAF EVACQQAGVR
     LQRYEHRADR PCGSTIGPLA SARTGIPTVD VGAAQLAMHS ARELMGAHDV AVYSAALQAF
     FSADLF