位置:首页 > 蛋白库 > IF2_FERNB
IF2_FERNB
ID   IF2_FERNB               Reviewed;         685 AA.
AC   A7HN01;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Translation initiation factor IF-2 {ECO:0000255|HAMAP-Rule:MF_00100};
GN   Name=infB {ECO:0000255|HAMAP-Rule:MF_00100}; OrderedLocusNames=Fnod_1441;
OS   Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1).
OC   Bacteria; Thermotogae; Thermotogales; Fervidobacteriaceae;
OC   Fervidobacterium.
OX   NCBI_TaxID=381764;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35602 / DSM 5306 / Rt17-B1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C.,
RA   Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.;
RT   "Complete sequence of Fervidobacterium nodosum Rt17-B1.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: One of the essential components for the initiation of protein
CC       synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis
CC       and promotes its binding to the 30S ribosomal subunits. Also involved
CC       in the hydrolysis of GTP during the formation of the 70S ribosomal
CC       complex. {ECO:0000255|HAMAP-Rule:MF_00100}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00100}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00100}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000771; ABS61284.1; -; Genomic_DNA.
DR   RefSeq; WP_011994589.1; NC_009718.1.
DR   AlphaFoldDB; A7HN01; -.
DR   SMR; A7HN01; -.
DR   STRING; 381764.Fnod_1441; -.
DR   EnsemblBacteria; ABS61284; ABS61284; Fnod_1441.
DR   KEGG; fno:Fnod_1441; -.
DR   eggNOG; COG0532; Bacteria.
DR   HOGENOM; CLU_006301_5_1_0; -.
DR   OMA; NRDNRTG; -.
DR   OrthoDB; 347113at2; -.
DR   Proteomes; UP000002415; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   CDD; cd03702; IF2_mtIF2_II; 1.
DR   Gene3D; 3.40.50.10050; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00100_B; IF_2_B; 1.
DR   InterPro; IPR044145; IF2_II.
DR   InterPro; IPR006847; IF2_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR000178; TF_IF2_bacterial-like.
DR   InterPro; IPR015760; TIF_IF2.
DR   InterPro; IPR023115; TIF_IF2_dom3.
DR   InterPro; IPR036925; TIF_IF2_dom3_sf.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   PANTHER; PTHR43381; PTHR43381; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF11987; IF-2; 1.
DR   Pfam; PF04760; IF2_N; 2.
DR   SUPFAM; SSF50447; SSF50447; 2.
DR   SUPFAM; SSF52156; SSF52156; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00487; IF-2; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; GTP-binding; Initiation factor; Nucleotide-binding;
KW   Protein biosynthesis; Reference proteome.
FT   CHAIN           1..685
FT                   /note="Translation initiation factor IF-2"
FT                   /id="PRO_1000071289"
FT   DOMAIN          175..352
FT                   /note="tr-type G"
FT   REGION          60..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          184..191
FT                   /note="G1"
FT                   /evidence="ECO:0000250"
FT   REGION          209..213
FT                   /note="G2"
FT                   /evidence="ECO:0000250"
FT   REGION          230..233
FT                   /note="G3"
FT                   /evidence="ECO:0000250"
FT   REGION          284..287
FT                   /note="G4"
FT                   /evidence="ECO:0000250"
FT   REGION          321..323
FT                   /note="G5"
FT                   /evidence="ECO:0000250"
FT   BINDING         184..191
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
FT   BINDING         230..234
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
FT   BINDING         284..287
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
SQ   SEQUENCE   685 AA;  77128 MW;  EE8EC897C1601254 CRC64;
     MARLRVYELA KQLDMDTKEL LHELEELGIE VKSHMSFIDE ETVNILLDIY KQTLDEEEDI
     SLAKTREPSK EKTEAKKPPV HITEADLKLD KFAEKIKIPQ NRIIQDFFMK GEILKPGQTI
     SISLAKKIAK MYDVRLTFEE DETAVKEQPK LENPLDELKR QFEEIYQNNK DKLVNRPPVV
     TVMGHVDHGK TTLLDYIRKT RVAEKEEGGI TQSVGAYQVI VNGKKITFID TPGHEVFTEM
     RARGAQATDI VVLVVAADDG VMPQTIEAYN HAKSANVPII VAINKIDKAN ANVDMTKQEL
     VTKLNLIPED WGGDTIVVPI SARNGINVDT LLEMILLVAE MQDIRCIPDS PVRAVTIETR
     LDKGYGPVAN AIVKDGVLKV GDYVVAGKVF GKVKALIDDK GKRLKEAEPS TPVMIVGFEE
     LPDPHSIIYV VDSKEKALEI VEKVREIEAR ELRKKRQVKL EEILKRMQET EKRELKLILK
     ADTVGSLQAL QNAIAKLRTN EIDIDIVHSA VGAINSSDIM LASASEAIIL GFRVKADNQA
     SKLAESEGVQ IKTYTIIYKL LEDLKAALEG MLEPEEVEEK TGYGEIKKAF KIHKYGNIAG
     VQMYDGYVDK SGFVRIYRNG ALVFEGKIES LKHYQQDVNK VSAPQECGIK FQNFDDIKEG
     DELEFYIIKK IPRKLTIIEE EKQQI
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024