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IF2_LEGPC
ID   IF2_LEGPC               Reviewed;         868 AA.
AC   A5IHU7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Translation initiation factor IF-2 {ECO:0000255|HAMAP-Rule:MF_00100};
GN   Name=infB {ECO:0000255|HAMAP-Rule:MF_00100}; OrderedLocusNames=LPC_3057;
OS   Legionella pneumophila (strain Corby).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=400673;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Corby;
RA   Gloeckner G., Albert-Weissenberger C., Weinmann E., Jacobi S., Schunder E.,
RA   Steinert M., Buchrieser C., Hacker J., Heuner K.;
RT   "Identification and characterization of a new conjugation/ type IVA
RT   secretion system (trb/tra) of L. pneumophila Corby localized on a mobile
RT   genomic island.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: One of the essential components for the initiation of protein
CC       synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis
CC       and promotes its binding to the 30S ribosomal subunits. Also involved
CC       in the hydrolysis of GTP during the formation of the 70S ribosomal
CC       complex. {ECO:0000255|HAMAP-Rule:MF_00100}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00100}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00100}.
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DR   EMBL; CP000675; ABQ56947.1; -; Genomic_DNA.
DR   RefSeq; WP_011947663.1; NC_009494.2.
DR   AlphaFoldDB; A5IHU7; -.
DR   SMR; A5IHU7; -.
DR   KEGG; lpc:LPC_3057; -.
DR   HOGENOM; CLU_006301_6_1_6; -.
DR   OMA; NRDNRTG; -.
DR   BioCyc; LPNE400673:LPC_RS14790-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   CDD; cd03702; IF2_mtIF2_II; 1.
DR   Gene3D; 3.40.50.10050; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00100_B; IF_2_B; 1.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR013575; IF2_assoc_dom_bac.
DR   InterPro; IPR044145; IF2_II.
DR   InterPro; IPR006847; IF2_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR000178; TF_IF2_bacterial-like.
DR   InterPro; IPR015760; TIF_IF2.
DR   InterPro; IPR023115; TIF_IF2_dom3.
DR   InterPro; IPR036925; TIF_IF2_dom3_sf.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   PANTHER; PTHR43381; PTHR43381; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF11987; IF-2; 1.
DR   Pfam; PF08364; IF2_assoc; 1.
DR   Pfam; PF04760; IF2_N; 2.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   SUPFAM; SSF50447; SSF50447; 2.
DR   SUPFAM; SSF52156; SSF52156; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00487; IF-2; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
DR   PROSITE; PS01176; IF2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; GTP-binding; Initiation factor; Nucleotide-binding;
KW   Protein biosynthesis.
FT   CHAIN           1..868
FT                   /note="Translation initiation factor IF-2"
FT                   /id="PRO_1000008264"
FT   DOMAIN          368..537
FT                   /note="tr-type G"
FT   REGION          201..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          377..384
FT                   /note="G1"
FT                   /evidence="ECO:0000250"
FT   REGION          402..406
FT                   /note="G2"
FT                   /evidence="ECO:0000250"
FT   REGION          423..426
FT                   /note="G3"
FT                   /evidence="ECO:0000250"
FT   REGION          477..480
FT                   /note="G4"
FT                   /evidence="ECO:0000250"
FT   REGION          513..515
FT                   /note="G5"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        201..228
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        234..250
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         377..384
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
FT   BINDING         423..427
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
FT   BINDING         477..480
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
SQ   SEQUENCE   868 AA;  94768 MW;  5EABA4C8C63D3788 CRC64;
     MADVTVKQLA QVVGIPVERL LNQLQEAGLS FTDDQQTVNE EQKRILLNHL KGSSNRDISA
     APERITLRRK SMSQVTVGHD MHSGKTVNIE VRKKKTFIKR SAIPEQAEVE EPVVPPVVEE
     PVHEEITVVS DVSAETPELK ETEEHPVIEP VAELDETVKE EEKINLEENT AESQDELAHA
     NTDVIENLVD VVEETIPVSK KEEVKPEKVS KKKHLEQTDT DISEFKKGKK KPKYHTFEHD
     EEEQELHRRG GRSKFKKKKG TEKSDKYREA EETLTHGFAL PTAPIVREVL IPETITVAEL
     AKRMSVKAAE VIKVMMSLGA MATINQVIDQ ETSVIVVEEM GHKPVIIKED AVETGLGEAI
     SKGTKTEGRA PVVTIMGHVD HGKTSLLDYI RRTKVAAGEA GGITQHIGAY HVSTPKGNIT
     FLDTPGHAAF TAMRARGAQA TDIVILIVAA DDGVKPQTIE AIQHAKAAKV PIIVAINKMD
     KPDADPERVM NELSVQEVIP EAWGGDTMFV NISAKSGMGI DDLLDAILLQ SEVLELKAVT
     DGAAKGVVIE SRLDKGRGPV ATVLVQSGTL HKGDILLAGF QYGRVRALVS DNGDLVDSAG
     PSIPVEVLGL SAIPHAGDEA VVVPDEKKAR EVALFRQGRF RDVKLARRQK TTIEGIMENM
     TATESKVLNI VLKADVQGSL EAISDALTKL STDEVKVEVI SSGVGGITES DVHLAIASNA
     ILIGFNVRAD GTAKRLAEQE SVSIHYYSVI YDIVDQIKGA LTGMLAPQFK EEIIGIAEVR
     DVFKSPKIGA IAGCMVIEGV VKRNNPIRVL RSNVVIYEGT LESLRRFKDD VLEVRQGFEC
     GIGVKNYNDV KPGDLIEVFE TVEIKRDL
 
 
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