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IF2_RENSM
ID   IF2_RENSM               Reviewed;         956 AA.
AC   A9WPV8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Translation initiation factor IF-2 {ECO:0000255|HAMAP-Rule:MF_00100};
GN   Name=infB {ECO:0000255|HAMAP-Rule:MF_00100};
GN   OrderedLocusNames=RSal33209_0656;
OS   Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 /
OS   NBRC 15589 / NCIMB 2235).
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Renibacterium.
OX   NCBI_TaxID=288705;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235;
RX   PubMed=18723615; DOI=10.1128/jb.00721-08;
RA   Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S.,
RA   Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H.,
RA   Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.;
RT   "Genome sequence of the fish pathogen Renibacterium salmoninarum suggests
RT   reductive evolution away from an environmental Arthrobacter ancestor.";
RL   J. Bacteriol. 190:6970-6982(2008).
CC   -!- FUNCTION: One of the essential components for the initiation of protein
CC       synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis
CC       and promotes its binding to the 30S ribosomal subunits. Also involved
CC       in the hydrolysis of GTP during the formation of the 70S ribosomal
CC       complex. {ECO:0000255|HAMAP-Rule:MF_00100}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00100}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00100}.
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DR   EMBL; CP000910; ABY22403.1; -; Genomic_DNA.
DR   AlphaFoldDB; A9WPV8; -.
DR   SMR; A9WPV8; -.
DR   STRING; 288705.RSal33209_0656; -.
DR   EnsemblBacteria; ABY22403; ABY22403; RSal33209_0656.
DR   KEGG; rsa:RSal33209_0656; -.
DR   eggNOG; COG0532; Bacteria.
DR   HOGENOM; CLU_006301_9_1_11; -.
DR   OMA; QVRPEMI; -.
DR   Proteomes; UP000002007; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   CDD; cd03702; IF2_mtIF2_II; 1.
DR   Gene3D; 3.40.50.10050; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00100_B; IF_2_B; 1.
DR   InterPro; IPR044145; IF2_II.
DR   InterPro; IPR006847; IF2_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR000178; TF_IF2_bacterial-like.
DR   InterPro; IPR015760; TIF_IF2.
DR   InterPro; IPR023115; TIF_IF2_dom3.
DR   InterPro; IPR036925; TIF_IF2_dom3_sf.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   PANTHER; PTHR43381; PTHR43381; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF11987; IF-2; 1.
DR   Pfam; PF04760; IF2_N; 2.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SUPFAM; SSF50447; SSF50447; 2.
DR   SUPFAM; SSF52156; SSF52156; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00487; IF-2; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
DR   PROSITE; PS01176; IF2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; GTP-binding; Initiation factor; Nucleotide-binding;
KW   Protein biosynthesis; Reference proteome.
FT   CHAIN           1..956
FT                   /note="Translation initiation factor IF-2"
FT                   /id="PRO_0000335502"
FT   DOMAIN          449..620
FT                   /note="tr-type G"
FT   REGION          68..357
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          458..465
FT                   /note="G1"
FT                   /evidence="ECO:0000250"
FT   REGION          483..487
FT                   /note="G2"
FT                   /evidence="ECO:0000250"
FT   REGION          508..511
FT                   /note="G3"
FT                   /evidence="ECO:0000250"
FT   REGION          562..565
FT                   /note="G4"
FT                   /evidence="ECO:0000250"
FT   REGION          598..600
FT                   /note="G5"
FT                   /evidence="ECO:0000250"
FT   BINDING         458..465
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
FT   BINDING         508..512
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
FT   BINDING         562..565
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
SQ   SEQUENCE   956 AA;  98746 MW;  B71C39AB05E014D5 CRC64;
     MPDSVRAETG ESVAKARVHE LAKELGITSK DAVAKLQELG EFVRSASSTI EAPVVKKLRD
     AFPDAVAAPE AAAPKAPARP APKAPAKPAE AQASVKPVET QAPATPAAAK AAATPVAPAA
     PAVKEQKEGS AARPGAGGPR PGNNPFATSQ GMPRAGARAE GERPAAAPAS GAGRPRPGGP
     RPGAPRPGNN PFASSQGMPR SGGRGDGERS GGPRPAAGSG GPRPAAGSGG PRPAAGSGGP
     RPGAGSGASR PGGGGGNRPT PGMMPNRTER PAPAGRGAGG GAGGPGRGGG ARPGGGAPAG
     GGFGKGGRGR GGTQGAFGKG GAGRGKQRKS KRAKRQELEQ MSAPSLGGVS VPRGDGNTVV
     RLRRGSSITD FADKIEANPA ALVTVLFHLG EMATATQSLD EETFALLGEE LGYKLQVVSP
     EDEERELLST FDIDFDAELE AEGDEDLQAR PPVVTVMGHV DHGKTRLLDA IRNSDVVAGE
     HGGITQHIGA YQVNHVHEGE VRKITFIDTP GHEAFTAMRA RGAKVTDIAI LVVAADDGVM
     PQTVEALNHA QAAGVPIVVA VNKIDKEGAN PEKIRGQLTE YGLVPEEYGG ETMFVDVSAR
     QNQNIDALLE AVMLTADAAL DLRANPNKDA RGIAIEANLD KGRGSVATVL VQSGTLAVGD
     TIVAGTAHGR VRAMFDDDGT AVTEAGPSRP VQVLGLSSVP RAGDTFFVTG DERTARQIAE
     KREAADRNAA LAKRRKRISL EDFDQAVADG KVDTLNLILK GDVSGAVEAL EDSLLKIDVG
     EGVQLRVIHR GVGAITQNDV NLATVDSAII IGFNVKPAER VAELADREGV DMRFYSVIYA
     AIDDIELALK GMLKPEYEEV QLGTAEIREI FRSSKFGNIA GSIVRSGLIR RNAKARVLRA
     GVLIGDNLTV DSLKRVKDDA TEVREGFECG IGLGSFNDLQ LEDIIETFEM REKPRV
 
 
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