位置:首页 > 蛋白库 > APEM9_ARATH
APEM9_ARATH
ID   APEM9_ARATH             Reviewed;         333 AA.
AC   Q8W4B2; Q9LPP1;
DT   18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Protein APEM9 {ECO:0000303|PubMed:21487094};
DE   AltName: Full=ABERRANT PEROXISOME MORPHOLOGY 9 {ECO:0000303|PubMed:21487094};
DE   AltName: Full=Protein DAYU {ECO:0000303|PubMed:24510720};
GN   Name=APEM9 {ECO:0000303|PubMed:21487094};
GN   Synonyms=DAU {ECO:0000303|PubMed:24510720};
GN   OrderedLocusNames=At3g10572 {ECO:0000312|Araport:AT3G10572};
GN   ORFNames=F18K10.16 {ECO:0000312|EMBL:AAF76360.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|EMBL:AAL32762.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   FUNCTION, MUTAGENESIS OF GLY-278, SUBCELLULAR LOCATION, INTERACTION WITH
RP   PEX6 AND PEX19-1, LACK OF INTERACTION WITH PEX1, TISSUE SPECIFICITY, AND
RP   DISRUPTION PHENOTYPE.
RX   PubMed=21487094; DOI=10.1105/tpc.110.080770;
RA   Goto S., Mano S., Nakamori C., Nishimura M.;
RT   "Arabidopsis ABERRANT PEROXISOME MORPHOLOGY9 is a peroxin that recruits the
RT   PEX1-PEX6 complex to peroxisomes.";
RL   Plant Cell 23:1573-1587(2011).
RN   [5]
RP   FUNCTION, DISRUPTION PHENOTYPE, TOPOLOGY, DEVELOPMENTAL STAGE, AND
RP   INTERACTION WITH PEX13 AND PEX16.
RX   PubMed=24510720; DOI=10.1105/tpc.113.121087;
RA   Li X.R., Li H.J., Yuan L., Liu M., Shi D.Q., Liu J., Yang W.C.;
RT   "Arabidopsis DAYU/ABERRANT PEROXISOME MORPHOLOGY9 is a key regulator of
RT   peroxisome biogenesis and plays critical roles during pollen maturation and
RT   germination in planta.";
RL   Plant Cell 26:619-635(2014).
CC   -!- FUNCTION: Involved in peroxisome biogenesis and matrix protein import
CC       (PubMed:24510720). Required for pollen maturation and in vivo
CC       germination via its role in peroxisomal function, which partially
CC       involves jasmonic acid biosynthesis (PubMed:24510720). Transported to
CC       peroxisomes via the interaction with PEX19-1 (PubMed:21487094).
CC       Required for peroxisomal protein import by acting as an anchoring
CC       protein for the AAA ATPase complex, which consists of PEX1 and PEX6
CC       (PubMed:21487094). {ECO:0000269|PubMed:21487094,
CC       ECO:0000269|PubMed:24510720}.
CC   -!- SUBUNIT: Interacts with PEX6 and PEX19-1, but not with PEX1
CC       (PubMed:21487094). Interacts (via N-terminus) with PEX13, and (via N-
CC       terminus and C-terminus) with PEX16 (PubMed:24510720).
CC       {ECO:0000269|PubMed:21487094, ECO:0000269|PubMed:24510720}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane
CC       {ECO:0000269|PubMed:21487094}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, leaves, stems, flowers, buds
CC       and fruits. {ECO:0000269|PubMed:21487094}.
CC   -!- DEVELOPMENTAL STAGE: Not detected in microspores before and at stage of
CC       pollen mitosis I. Expressed in bicellular, tricellular and mature
CC       pollen grains. {ECO:0000269|PubMed:24510720}.
CC   -!- DISRUPTION PHENOTYPE: Embryo lethality, when homozygous.
CC       {ECO:0000269|PubMed:21487094, ECO:0000269|PubMed:24510720}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF76360.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC013428; AAF76360.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE74927.1; -; Genomic_DNA.
DR   EMBL; AY062684; AAL32762.1; -; mRNA.
DR   EMBL; AY093365; AAM13364.1; -; mRNA.
DR   RefSeq; NP_850555.1; NM_180224.4.
DR   AlphaFoldDB; Q8W4B2; -.
DR   SMR; Q8W4B2; -.
DR   IntAct; Q8W4B2; 1.
DR   STRING; 3702.AT3G10572.1; -.
DR   PaxDb; Q8W4B2; -.
DR   PRIDE; Q8W4B2; -.
DR   ProteomicsDB; 244965; -.
DR   EnsemblPlants; AT3G10572.1; AT3G10572.1; AT3G10572.
DR   GeneID; 820223; -.
DR   Gramene; AT3G10572.1; AT3G10572.1; AT3G10572.
DR   KEGG; ath:AT3G10572; -.
DR   Araport; AT3G10572; -.
DR   TAIR; locus:1005716603; AT3G10572.
DR   eggNOG; ENOG502QV2J; Eukaryota.
DR   HOGENOM; CLU_044007_0_0_1; -.
DR   InParanoid; Q8W4B2; -.
DR   OMA; CMFEEAA; -.
DR   OrthoDB; 1076056at2759; -.
DR   PhylomeDB; Q8W4B2; -.
DR   PRO; PR:Q8W4B2; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q8W4B2; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; HDA:TAIR.
DR   GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005777; C:peroxisome; IDA:TAIR.
DR   GO; GO:0015919; P:peroxisomal membrane transport; IEA:InterPro.
DR   GO; GO:0043574; P:peroxisomal transport; IMP:TAIR.
DR   InterPro; IPR034571; APEM9.
DR   PANTHER; PTHR36361; PTHR36361; 1.
PE   1: Evidence at protein level;
KW   Membrane; Peroxisome; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..333
FT                   /note="Protein APEM9"
FT                   /id="PRO_0000438625"
FT   TOPO_DOM        1..90
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305|PubMed:24510720"
FT   TRANSMEM        91..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000305|PubMed:24510720"
FT   TOPO_DOM        103..268
FT                   /note="Peroxisomal"
FT                   /evidence="ECO:0000305|PubMed:24510720"
FT   TRANSMEM        269..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255, ECO:0000305|PubMed:24510720"
FT   TOPO_DOM        286..333
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305|PubMed:24510720"
FT   MUTAGEN         278
FT                   /note="G->E: In apem9-1; loss of peroxisomal localization,
FT                   but no effect on the interaction with PEX6."
FT                   /evidence="ECO:0000269|PubMed:21487094"
SQ   SEQUENCE   333 AA;  37467 MW;  B473AABE121A41F7 CRC64;
     MEATDIWGEI ERSESYLVCS MYEEAESLSS SILKRIFGNI DVLSDEASQG DHQFHDMLES
     AGMVLVQSLH GIGRTVEIVN ELRDVFGEVA AIPVQVLLTG VCLQISNGSY LGVRDILEEF
     FRIWVYKDNH YILNDAGVST KGFHAKNCLD IDEYMEVVEL YTFGVLAKFS NDMGLAISWV
     EKAALPEERR QGILRRLHSL LSLKTASSFE ENSKDSSYAV VNNKKSLGNE KNDEIDSFLK
     LSKQHEPWSL WSSHPLSLKV GNTQFSMSRG KVAVSLVGLI ICYALKRKRA ALIRIIRRQM
     ESTRKAIVDF WKLAFSYQVN PLAAIQSIPS TTT
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024