IF3_BUCAP
ID IF3_BUCAP Reviewed; 179 AA.
AC P46243;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2002, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Translation initiation factor IF-3 {ECO:0000255|HAMAP-Rule:MF_00080};
GN Name=infC {ECO:0000255|HAMAP-Rule:MF_00080}; OrderedLocusNames=BUsg_118;
OS Buchnera aphidicola subsp. Schizaphis graminum (strain Sg).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Buchnera.
OX NCBI_TaxID=198804;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7766160; DOI=10.1007/bf00295507;
RA Kolibachuk D., Rouhbakhsh D., Baumann P.;
RT "Aromatic amino acid biosynthesis in Buchnera aphidicola (endosymbiont of
RT aphids): cloning and sequencing of a DNA fragment containing aroH-thrS-
RT infC-rpmI-rplT.";
RL Curr. Microbiol. 30:313-316(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sg;
RX PubMed=12089438; DOI=10.1126/science.1071278;
RA Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT "50 million years of genomic stasis in endosymbiotic bacteria.";
RL Science 296:2376-2379(2002).
CC -!- FUNCTION: IF-3 binds to the 30S ribosomal subunit and shifts the
CC equilibrum between 70S ribosomes and their 50S and 30S subunits in
CC favor of the free subunits, thus enhancing the availability of 30S
CC subunits on which protein synthesis initiation begins.
CC {ECO:0000255|HAMAP-Rule:MF_00080}.
CC -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00080}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00080}.
CC -!- SIMILARITY: Belongs to the IF-3 family. {ECO:0000255|HAMAP-
CC Rule:MF_00080}.
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DR EMBL; U11066; AAC43606.1; -; Genomic_DNA.
DR EMBL; AE013218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; I40072; I40072.
DR RefSeq; WP_011053653.1; NC_004061.1.
DR AlphaFoldDB; P46243; -.
DR SMR; P46243; -.
DR OMA; RNMIMFL; -.
DR OrthoDB; 1760144at2; -.
DR Proteomes; UP000000416; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.10.20.80; -; 1.
DR Gene3D; 3.30.110.10; -; 1.
DR HAMAP; MF_00080; IF_3; 1.
DR InterPro; IPR036788; T_IF-3_C_sf.
DR InterPro; IPR036787; T_IF-3_N_sf.
DR InterPro; IPR019813; Translation_initiation_fac3_CS.
DR InterPro; IPR001288; Translation_initiation_fac_3.
DR InterPro; IPR019815; Translation_initiation_fac_3_C.
DR InterPro; IPR019814; Translation_initiation_fac_3_N.
DR PANTHER; PTHR10938; PTHR10938; 1.
DR Pfam; PF00707; IF3_C; 1.
DR Pfam; PF05198; IF3_N; 1.
DR SUPFAM; SSF54364; SSF54364; 1.
DR SUPFAM; SSF55200; SSF55200; 1.
DR TIGRFAMs; TIGR00168; infC; 1.
DR PROSITE; PS00938; IF3; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis.
FT CHAIN 1..179
FT /note="Translation initiation factor IF-3"
FT /id="PRO_0000177496"
FT SITE 107
FT /note="Important for 30S binding"
FT /evidence="ECO:0000250"
FT SITE 110
FT /note="Important for 30S binding"
FT /evidence="ECO:0000250"
FT CONFLICT 26
FT /note="L -> V (in Ref. 1; AAC43606)"
FT /evidence="ECO:0000305"
FT CONFLICT 42..44
FT /note="ALE -> LR (in Ref. 1; AAC43606)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 179 AA; 20659 MW; 448FCC27BF09CED1 CRC64;
MKGGKRIQFT RPNRINNEIR AIKVRLTGVE GDQIGIVNLR EALEKAEELG LDLVEISPNA
EPPVCRIMDY GKFLYEKSKS SKEQKKKQKV IQVKEIKFRP STDEGDYQVK LRNLIRFLED
GDKVKITLRF RGREMAHQKI GIDVLNRVKN DLIELAIIES FPSKIEGRQM IMVLAPKKK
