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APF2_ARATH
ID   APF2_ARATH              Reviewed;         485 AA.
AC   Q9LNJ3; Q8L9B9;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 152.
DE   RecName: Full=Aspartyl protease family protein 2 {ECO:0000305};
DE            EC=3.4.23.- {ECO:0000305};
DE   Flags: Precursor;
GN   Name=APF2 {ECO:0000305};
GN   OrderedLocusNames=At1g01300 {ECO:0000312|Araport:AT1G01300};
GN   ORFNames=F6F3.10 {ECO:0000312|EMBL:AAF97328.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY.
RX   PubMed=16381599; DOI=10.2174/138920305774933268;
RA   Faro C., Gal S.;
RT   "Aspartic proteinase content of the Arabidopsis genome.";
RL   Curr. Protein Pept. Sci. 6:493-500(2005).
RN   [6]
RP   FUNCTION.
RX   PubMed=26739014; DOI=10.1105/tpc.15.00626;
RA   Li Y., Kabbage M., Liu W., Dickman M.B.;
RT   "Aspartyl protease-mediated cleavage of BAG6 is necessary for autophagy and
RT   fungal resistance in plants.";
RL   Plant Cell 28:233-247(2016).
CC   -!- FUNCTION: Aspartyl protease. Not able to cleave BAG6.
CC       {ECO:0000269|PubMed:26739014}.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family. {ECO:0000305}.
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DR   EMBL; AC023628; AAF97328.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE27268.1; -; Genomic_DNA.
DR   EMBL; AY128344; AAM91547.1; -; mRNA.
DR   EMBL; BT006619; AAP31963.1; -; mRNA.
DR   EMBL; AY088528; AAM66061.1; -; mRNA.
DR   PIR; C86143; C86143.
DR   RefSeq; NP_171637.1; NM_100012.3.
DR   AlphaFoldDB; Q9LNJ3; -.
DR   SMR; Q9LNJ3; -.
DR   IntAct; Q9LNJ3; 1.
DR   STRING; 3702.AT1G01300.1; -.
DR   MEROPS; A01.A05; -.
DR   iPTMnet; Q9LNJ3; -.
DR   MetOSite; Q9LNJ3; -.
DR   SwissPalm; Q9LNJ3; -.
DR   PaxDb; Q9LNJ3; -.
DR   PRIDE; Q9LNJ3; -.
DR   ProteomicsDB; 246776; -.
DR   EnsemblPlants; AT1G01300.1; AT1G01300.1; AT1G01300.
DR   GeneID; 839375; -.
DR   Gramene; AT1G01300.1; AT1G01300.1; AT1G01300.
DR   KEGG; ath:AT1G01300; -.
DR   Araport; AT1G01300; -.
DR   TAIR; locus:2035297; AT1G01300.
DR   eggNOG; KOG1339; Eukaryota.
DR   HOGENOM; CLU_005738_5_0_1; -.
DR   InParanoid; Q9LNJ3; -.
DR   OMA; PPRYVYM; -.
DR   OrthoDB; 753343at2759; -.
DR   PhylomeDB; Q9LNJ3; -.
DR   PRO; PR:Q9LNJ3; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9LNJ3; baseline and differential.
DR   GO; GO:0009505; C:plant-type cell wall; HDA:TAIR.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd05472; cnd41_like; 1.
DR   Gene3D; 2.40.70.10; -; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR033873; CND41-like.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   InterPro; IPR032799; TAXi_C.
DR   InterPro; IPR032861; TAXi_N.
DR   PANTHER; PTHR13683; PTHR13683; 1.
DR   Pfam; PF14541; TAXi_C; 1.
DR   Pfam; PF14543; TAXi_N; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; SSF50630; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 2.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Protease; Reference proteome; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..485
FT                   /note="Aspartyl protease family protein 2"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5005943290"
FT   DOMAIN          142..480
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01103"
FT   REGION          43..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        160
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10094"
FT   ACT_SITE        365
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10094"
FT   CONFLICT        89
FT                   /note="D -> Q (in Ref. 4; AAM66061)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        104
FT                   /note="K -> R (in Ref. 4; AAM66061)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        397
FT                   /note="D -> N (in Ref. 4; AAM66061)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        424
FT                   /note="G -> R (in Ref. 4; AAM66061)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   485 AA;  52175 MW;  1A71782027531709 CRC64;
     MVGRRKALLF SLCFFFLSLP SFSSLPSFQT LFPNSHSLPC ASPVSFQPDS DSESLLESEF
     ESGSDSESSS SITLNLDHID ALSSNKTPDE LFSSRLQRDS RRVKSIATLA AQIPGRNVTH
     APRPGGFSSS VVSGLSQGSG EYFTRLGVGT PARYVYMVLD TGSDIVWLQC APCRRCYSQS
     DPIFDPRKSK TYATIPCSSP HCRRLDSAGC NTRRKTCLYQ VSYGDGSFTV GDFSTETLTF
     RRNRVKGVAL GCGHDNEGLF VGAAGLLGLG KGKLSFPGQT GHRFNQKFSY CLVDRSASSK
     PSSVVFGNAA VSRIARFTPL LSNPKLDTFY YVGLLGISVG GTRVPGVTAS LFKLDQIGNG
     GVIIDSGTSV TRLIRPAYIA MRDAFRVGAK TLKRAPDFSL FDTCFDLSNM NEVKVPTVVL
     HFRGADVSLP ATNYLIPVDT NGKFCFAFAG TMGGLSIIGN IQQQGFRVVY DLASSRVGFA
     PGGCA
 
 
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