ID   IF3_HELPJ               Reviewed;         203 AA.
AC   Q9ZMV2;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Translation initiation factor IF-3 {ECO:0000255|HAMAP-Rule:MF_00080};
GN   Name=infC {ECO:0000255|HAMAP-Rule:MF_00080}; OrderedLocusNames=jhp_0114;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- FUNCTION: IF-3 binds to the 30S ribosomal subunit and shifts the
CC       equilibrum between 70S ribosomes and their 50S and 30S subunits in
CC       favor of the free subunits, thus enhancing the availability of 30S
CC       subunits on which protein synthesis initiation begins.
CC       {ECO:0000255|HAMAP-Rule:MF_00080}.
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00080}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00080}.
CC   -!- SIMILARITY: Belongs to the IF-3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00080}.
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DR   EMBL; AE001439; AAD05693.1; -; Genomic_DNA.
DR   PIR; H71972; H71972.
DR   RefSeq; WP_000089205.1; NZ_CP011330.1.
DR   PDB; 6O6D; X-ray; 1.82 A; A=2-77.
DR   PDBsum; 6O6D; -.
DR   AlphaFoldDB; Q9ZMV2; -.
DR   SMR; Q9ZMV2; -.
DR   STRING; 85963.jhp_0114; -.
DR   EnsemblBacteria; AAD05693; AAD05693; jhp_0114.
DR   KEGG; hpj:jhp_0114; -.
DR   PATRIC; fig|85963.30.peg.914; -.
DR   eggNOG; COG0290; Bacteria.
DR   OMA; RNMIMFL; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.10.20.80; -; 1.
DR   Gene3D; 3.30.110.10; -; 1.
DR   HAMAP; MF_00080; IF_3; 1.
DR   InterPro; IPR036788; T_IF-3_C_sf.
DR   InterPro; IPR036787; T_IF-3_N_sf.
DR   InterPro; IPR019813; Translation_initiation_fac3_CS.
DR   InterPro; IPR001288; Translation_initiation_fac_3.
DR   InterPro; IPR019815; Translation_initiation_fac_3_C.
DR   InterPro; IPR019814; Translation_initiation_fac_3_N.
DR   PANTHER; PTHR10938; PTHR10938; 1.
DR   Pfam; PF00707; IF3_C; 1.
DR   Pfam; PF05198; IF3_N; 1.
DR   SUPFAM; SSF54364; SSF54364; 1.
DR   SUPFAM; SSF55200; SSF55200; 1.
DR   TIGRFAMs; TIGR00168; infC; 1.
DR   PROSITE; PS00938; IF3; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Initiation factor; Protein biosynthesis.
FT   CHAIN           1..203
FT                   /note="Translation initiation factor IF-3"
FT                   /id="PRO_0000177526"
FT   REGION          172..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   HELIX           9..11
FT                   /evidence="ECO:0007829|PDB:6O6D"
FT   STRAND          17..21
FT                   /evidence="ECO:0007829|PDB:6O6D"
FT   STRAND          26..30
FT                   /evidence="ECO:0007829|PDB:6O6D"
FT   HELIX           32..42
FT                   /evidence="ECO:0007829|PDB:6O6D"
FT   STRAND          45..55
FT                   /evidence="ECO:0007829|PDB:6O6D"
FT   STRAND          57..61
FT                   /evidence="ECO:0007829|PDB:6O6D"
FT   HELIX           63..69
FT                   /evidence="ECO:0007829|PDB:6O6D"
SQ   SEQUENCE   203 AA;  23333 MW;  E4CBD4C2353E4E32 CRC64;
     MSRNEVLLNG DINFKEVRCV GDNGEVYGII SSKEALKIAQ NLGLDLVLIS ASAKPPVCKV
     MDYNKFRYQN EKKIKEAKKK QKQIEIKEIK LSTQIAQNDI NYKVKHAREF IESNKHVKFK
     VVLKGRESQN SKAGLDVLFR VQTMMQDLAN PEKEPKTEGR FVSWMFVPKA KEAPKNEKKT
     KENNPPFNRI NLMKGENHAK NED