ID   IF3_KLEPN               Reviewed;         180 AA.
AC   P33318;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Translation initiation factor IF-3 {ECO:0000255|HAMAP-Rule:MF_00080};
GN   Name=infC {ECO:0000255|HAMAP-Rule:MF_00080};
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 13883 / DSM 30104 / JCM 1662 / NBRC 14940 / NCIMB 13281 / NCTC
RC   9633;
RX   PubMed=8405963; DOI=10.1111/j.1574-6968.1993.tb06450.x;
RA   Liveris D., Schwartz J.J., Geertman R., Schwartz I.;
RT   "Molecular cloning and sequencing of infC, the gene encoding translation
RT   initiation factor IF3, from four enterobacterial species.";
RL   FEMS Microbiol. Lett. 112:211-216(1993).
CC   -!- FUNCTION: IF-3 binds to the 30S ribosomal subunit and shifts the
CC       equilibrum between 70S ribosomes and their 50S and 30S subunits in
CC       favor of the free subunits, thus enhancing the availability of 30S
CC       subunits on which protein synthesis initiation begins.
CC       {ECO:0000255|HAMAP-Rule:MF_00080}.
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00080}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00080}.
CC   -!- SIMILARITY: Belongs to the IF-3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00080}.
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DR   EMBL; L11255; AAC36811.1; -; Unassigned_DNA.
DR   AlphaFoldDB; P33318; -.
DR   SMR; P33318; -.
DR   PRIDE; P33318; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.10.20.80; -; 1.
DR   Gene3D; 3.30.110.10; -; 1.
DR   HAMAP; MF_00080; IF_3; 1.
DR   InterPro; IPR036788; T_IF-3_C_sf.
DR   InterPro; IPR036787; T_IF-3_N_sf.
DR   InterPro; IPR019813; Translation_initiation_fac3_CS.
DR   InterPro; IPR001288; Translation_initiation_fac_3.
DR   InterPro; IPR019815; Translation_initiation_fac_3_C.
DR   InterPro; IPR019814; Translation_initiation_fac_3_N.
DR   PANTHER; PTHR10938; PTHR10938; 1.
DR   Pfam; PF00707; IF3_C; 1.
DR   Pfam; PF05198; IF3_N; 1.
DR   SUPFAM; SSF54364; SSF54364; 1.
DR   SUPFAM; SSF55200; SSF55200; 1.
DR   TIGRFAMs; TIGR00168; infC; 1.
DR   PROSITE; PS00938; IF3; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis.
FT   CHAIN           1..180
FT                   /note="Translation initiation factor IF-3"
FT                   /id="PRO_0000177528"
FT   SITE            107
FT                   /note="Important for 30S binding"
FT                   /evidence="ECO:0000250"
FT   SITE            110
FT                   /note="Important for 30S binding"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   180 AA;  20505 MW;  16220CD9EA597ABB CRC64;
     MKGGKRVQTA RPNRINGEIR AQEVRLTGLE GEQLGIVSLR EAIEKAEEAG VDLVEISPNA
     EPPVCRIMDY GKFLYEKSKS SKEQKKKQKV IQVKEIKFRP GTDEGDYQVK LRSLIRFLED
     GDKAKITLRF RGREMAHQQI GMEVLNRVKD DLVELAVVEA FPTKIEGRQM IMVLAPKKKQ