ID   IF3_PROHU               Reviewed;         179 AA.
AC   P33319;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Translation initiation factor IF-3 {ECO:0000255|HAMAP-Rule:MF_00080};
GN   Name=infC {ECO:0000255|HAMAP-Rule:MF_00080};
OS   Proteus hauseri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Proteus.
OX   NCBI_TaxID=183417;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 13315 / DSM 30118 / JCM 1668 / NBRC 3851 / NCIMB 4175 / NCTC
RC   4175 / NRRL B-3405;
RX   PubMed=8405963; DOI=10.1111/j.1574-6968.1993.tb06450.x;
RA   Liveris D., Schwartz J.J., Geertman R., Schwartz I.;
RT   "Molecular cloning and sequencing of infC, the gene encoding translation
RT   initiation factor IF3, from four enterobacterial species.";
RL   FEMS Microbiol. Lett. 112:211-216(1993).
CC   -!- FUNCTION: IF-3 binds to the 30S ribosomal subunit and shifts the
CC       equilibrum between 70S ribosomes and their 50S and 30S subunits in
CC       favor of the free subunits, thus enhancing the availability of 30S
CC       subunits on which protein synthesis initiation begins.
CC       {ECO:0000255|HAMAP-Rule:MF_00080}.
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00080}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00080}.
CC   -!- SIMILARITY: Belongs to the IF-3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00080}.
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DR   EMBL; L11257; AAC36812.1; -; Unassigned_DNA.
DR   AlphaFoldDB; P33319; -.
DR   SMR; P33319; -.
DR   STRING; 1354271.M997_1724; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.10.20.80; -; 1.
DR   Gene3D; 3.30.110.10; -; 1.
DR   HAMAP; MF_00080; IF_3; 1.
DR   InterPro; IPR036788; T_IF-3_C_sf.
DR   InterPro; IPR036787; T_IF-3_N_sf.
DR   InterPro; IPR019813; Translation_initiation_fac3_CS.
DR   InterPro; IPR001288; Translation_initiation_fac_3.
DR   InterPro; IPR019815; Translation_initiation_fac_3_C.
DR   InterPro; IPR019814; Translation_initiation_fac_3_N.
DR   PANTHER; PTHR10938; PTHR10938; 1.
DR   Pfam; PF00707; IF3_C; 1.
DR   Pfam; PF05198; IF3_N; 1.
DR   SUPFAM; SSF54364; SSF54364; 1.
DR   SUPFAM; SSF55200; SSF55200; 1.
DR   TIGRFAMs; TIGR00168; infC; 1.
DR   PROSITE; PS00938; IF3; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis.
FT   CHAIN           1..179
FT                   /note="Translation initiation factor IF-3"
FT                   /id="PRO_0000177556"
FT   SITE            107
FT                   /note="Important for 30S binding"
FT                   /evidence="ECO:0000250"
FT   SITE            110
FT                   /note="Important for 30S binding"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   179 AA;  20535 MW;  CA0650013E76D71D CRC64;
     MKGGKRIQST RQNRINSEIR AHEVRLTGLD GEQIGVVSLK EALEKAEEAG ADLVEISPNA
     EPPVCRIMDY GKFLYEKSKT LKEQKKEQKV IQVKEVKFRP GTDEGDYQVK LRNLIRFLED
     GDKAKVTLRF RGREMAHQQI GMEVLNRIRQ DLDELATVES FPNKIEGRQM IMVLAPKKK