IF3_PSEAE
ID IF3_PSEAE Reviewed; 183 AA.
AC Q9I0A0;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Translation initiation factor IF-3 {ECO:0000255|HAMAP-Rule:MF_00080};
GN Name=infC {ECO:0000255|HAMAP-Rule:MF_00080}; OrderedLocusNames=PA2743;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: IF-3 binds to the 30S ribosomal subunit and shifts the
CC equilibrum between 70S ribosomes and their 50S and 30S subunits in
CC favor of the free subunits, thus enhancing the availability of 30S
CC subunits on which protein synthesis initiation begins.
CC {ECO:0000255|HAMAP-Rule:MF_00080}.
CC -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00080}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00080}.
CC -!- SIMILARITY: Belongs to the IF-3 family. {ECO:0000255|HAMAP-
CC Rule:MF_00080}.
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DR EMBL; AE004091; AAG06131.1; -; Genomic_DNA.
DR PIR; E83303; E83303.
DR RefSeq; NP_251433.1; NC_002516.2.
DR RefSeq; WP_003119938.1; NZ_CP053028.1.
DR PDB; 6VRJ; NMR; -; A=87-183.
DR PDBsum; 6VRJ; -.
DR AlphaFoldDB; Q9I0A0; -.
DR SMR; Q9I0A0; -.
DR STRING; 287.DR97_5219; -.
DR PaxDb; Q9I0A0; -.
DR PRIDE; Q9I0A0; -.
DR DNASU; 879427; -.
DR EnsemblBacteria; AAG06131; AAG06131; PA2743.
DR GeneID; 879427; -.
DR KEGG; pae:PA2743; -.
DR PATRIC; fig|208964.12.peg.2868; -.
DR PseudoCAP; PA2743; -.
DR HOGENOM; CLU_054919_3_2_6; -.
DR InParanoid; Q9I0A0; -.
DR OMA; RNMIMFL; -.
DR PhylomeDB; Q9I0A0; -.
DR BioCyc; PAER208964:G1FZ6-2782-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0032790; P:ribosome disassembly; IBA:GO_Central.
DR Gene3D; 3.10.20.80; -; 1.
DR Gene3D; 3.30.110.10; -; 1.
DR HAMAP; MF_00080; IF_3; 1.
DR InterPro; IPR036788; T_IF-3_C_sf.
DR InterPro; IPR036787; T_IF-3_N_sf.
DR InterPro; IPR001288; Translation_initiation_fac_3.
DR InterPro; IPR019815; Translation_initiation_fac_3_C.
DR InterPro; IPR019814; Translation_initiation_fac_3_N.
DR PANTHER; PTHR10938; PTHR10938; 1.
DR Pfam; PF00707; IF3_C; 1.
DR Pfam; PF05198; IF3_N; 1.
DR SUPFAM; SSF54364; SSF54364; 1.
DR SUPFAM; SSF55200; SSF55200; 1.
DR TIGRFAMs; TIGR00168; infC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Initiation factor; Protein biosynthesis;
KW Reference proteome.
FT CHAIN 1..183
FT /note="Translation initiation factor IF-3"
FT /id="PRO_0000177557"
FT STRAND 89..93
FT /evidence="ECO:0007829|PDB:6VRJ"
FT STRAND 98..102
FT /evidence="ECO:0007829|PDB:6VRJ"
FT HELIX 108..124
FT /evidence="ECO:0007829|PDB:6VRJ"
FT STRAND 128..132
FT /evidence="ECO:0007829|PDB:6VRJ"
FT HELIX 138..157
FT /evidence="ECO:0007829|PDB:6VRJ"
FT STRAND 160..169
FT /evidence="ECO:0007829|PDB:6VRJ"
FT STRAND 172..180
FT /evidence="ECO:0007829|PDB:6VRJ"
SQ SEQUENCE 183 AA; 20882 MW; 4D5D6BA4FC2F084B CRC64;
MIIKREMRQD KRAQPKPPIN ENISAREVRL IGADGQQVGV VSIDEAIRLA EEAKLDLVEI
SADAVPPVCR IMDYGKHLFE KKKQAAVAKK NQKQAQVKEI KFRPGTEEGD YQVKLRNLVR
FLSEGDKAKV SLRFRGREMA HQELGMELLK RVEADLVEYG TVEQHPKLEG RQLMMVIAPK
KKK
