ID   APGM1_METTH             Reviewed;         409 AA.
AC   O27628;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1;
DE            Short=BPG-independent PGAM 1;
DE            Short=Phosphoglyceromutase 1;
DE            Short=aPGAM 1;
DE            EC=5.4.2.12;
GN   Name=apgM1; OrderedLocusNames=MTH_1591;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Catalyzes the interconversion of 2-phosphoglycerate and 3-
CC       phosphoglycerate. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate;
CC         Xref=Rhea:RHEA:15901, ChEBI:CHEBI:58272, ChEBI:CHEBI:58289;
CC         EC=5.4.2.12;
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC       glyceraldehyde 3-phosphate: step 3/5.
CC   -!- SIMILARITY: Belongs to the BPG-independent phosphoglycerate mutase
CC       family. A-PGAM subfamily. {ECO:0000305}.
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DR   EMBL; AE000666; AAB86064.1; -; Genomic_DNA.
DR   PIR; D69079; D69079.
DR   RefSeq; WP_010877199.1; NC_000916.1.
DR   AlphaFoldDB; O27628; -.
DR   SMR; O27628; -.
DR   STRING; 187420.MTH_1591; -.
DR   EnsemblBacteria; AAB86064; AAB86064; MTH_1591.
DR   GeneID; 1471860; -.
DR   KEGG; mth:MTH_1591; -.
DR   PATRIC; fig|187420.15.peg.1554; -.
DR   HOGENOM; CLU_034906_2_0_2; -.
DR   OMA; IAFRCNF; -.
DR   BioCyc; MetaCyc:MON-14536; -.
DR   UniPathway; UPA00109; UER00186.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0046537; F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd16011; iPGM_like; 1.
DR   Gene3D; 3.30.70.2130; -; 1.
DR   Gene3D; 3.40.720.10; -; 2.
DR   HAMAP; MF_01402_A; ApgM_A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR023665; ApgAM_prokaryotes.
DR   InterPro; IPR006124; Metalloenzyme.
DR   InterPro; IPR004456; Pglycerate_mutase_ApgM.
DR   InterPro; IPR042253; Pglycerate_mutase_ApgM_sf.
DR   PANTHER; PTHR31209; PTHR31209; 1.
DR   Pfam; PF01676; Metalloenzyme; 1.
DR   Pfam; PF10143; PhosphMutase; 1.
DR   PIRSF; PIRSF006392; IPGAM_arch; 1.
DR   SUPFAM; SSF53649; SSF53649; 1.
DR   TIGRFAMs; TIGR00306; apgM; 1.
PE   3: Inferred from homology;
KW   Glycolysis; Isomerase; Reference proteome.
FT   CHAIN           1..409
FT                   /note="2,3-bisphosphoglycerate-independent phosphoglycerate
FT                   mutase 1"
FT                   /id="PRO_0000138139"
FT   REGION          163..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   409 AA;  43778 MW;  9D6B67E5FA823304 CRC64;
     MKGVIMIIDG MADRPLEKLS GRTPLEAAST PNMDRIAESG INGIMDPIKP GVRAGSDTSH
     LSILGYDPYR VYTGRGPFEA AGVGLDVKPG DIAFRCNFAT ADEDMIITDR RAGRIRSGTS
     SIARTINSMT IEGFEDVEII FRESTGHRAV LVLRGPGLGD KVSDADPKVE GKPPKKIKAL
     DGSPESRKTA EVLNRIVKES YEILRDHPVN TGRIERGEAP ANIILPRGAG AVPHVEKFQE
     RYDLKAACIA ETGLIKGIGH LTGMDVIDVE GATGGIDTDL ESIKNAISSA IAADYDFLLI
     NIDGADEAGH DGDLEGKVRF IERVDSILGD LMGDDIYFIL TADHSTPVSV MDHTGDPVPI
     AITGPEVRVD DVTSFSERAA AAGGLCRIRG SDVMDILLDL MNKKEKFGA