ID   IF3_SERMA               Reviewed;         183 AA.
AC   P33320;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Translation initiation factor IF-3 {ECO:0000255|HAMAP-Rule:MF_00080};
GN   Name=infC {ECO:0000255|HAMAP-Rule:MF_00080};
OS   Serratia marcescens.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 29937 / 868-57;
RX   PubMed=8405963; DOI=10.1111/j.1574-6968.1993.tb06450.x;
RA   Liveris D., Schwartz J.J., Geertman R., Schwartz I.;
RT   "Molecular cloning and sequencing of infC, the gene encoding translation
RT   initiation factor IF3, from four enterobacterial species.";
RL   FEMS Microbiol. Lett. 112:211-216(1993).
CC   -!- FUNCTION: IF-3 binds to the 30S ribosomal subunit and shifts the
CC       equilibrum between 70S ribosomes and their 50S and 30S subunits in
CC       favor of the free subunits, thus enhancing the availability of 30S
CC       subunits on which protein synthesis initiation begins.
CC       {ECO:0000255|HAMAP-Rule:MF_00080}.
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00080}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00080}.
CC   -!- SIMILARITY: Belongs to the IF-3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00080}.
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DR   EMBL; L11256; AAC36813.1; -; Unassigned_DNA.
DR   AlphaFoldDB; P33320; -.
DR   SMR; P33320; -.
DR   STRING; 273526.SMDB11_1417; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.10.20.80; -; 1.
DR   Gene3D; 3.30.110.10; -; 1.
DR   HAMAP; MF_00080; IF_3; 1.
DR   InterPro; IPR036788; T_IF-3_C_sf.
DR   InterPro; IPR036787; T_IF-3_N_sf.
DR   InterPro; IPR019813; Translation_initiation_fac3_CS.
DR   InterPro; IPR001288; Translation_initiation_fac_3.
DR   InterPro; IPR019815; Translation_initiation_fac_3_C.
DR   InterPro; IPR019814; Translation_initiation_fac_3_N.
DR   PANTHER; PTHR10938; PTHR10938; 1.
DR   Pfam; PF00707; IF3_C; 1.
DR   Pfam; PF05198; IF3_N; 1.
DR   SUPFAM; SSF54364; SSF54364; 1.
DR   SUPFAM; SSF55200; SSF55200; 1.
DR   TIGRFAMs; TIGR00168; infC; 1.
DR   PROSITE; PS00938; IF3; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis.
FT   CHAIN           1..183
FT                   /note="Translation initiation factor IF-3"
FT                   /id="PRO_0000177572"
FT   SITE            107
FT                   /note="Important for 30S binding"
FT                   /evidence="ECO:0000250"
FT   SITE            110
FT                   /note="Important for 30S binding"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   183 AA;  20877 MW;  BA13FB0F76287603 CRC64;
     MKGGKRVQPA RPNRINREIR AQEVRLTGVD GEQIGIVSLN EALEKAEEAG VDLVEISPNA
     EPPVCRIMDY GKFLYEKSKS TKEQKEEQKV IQVKEIKFRP GTDDGDYQVK LRNLIRFLED
     GDKAKITLRF RGPEMAHQQI GMEVLNPLRK DLCEDMDLAV VESFPTKIEG RQMIMVLAPK
     KKQ