ID   IF3_STRPN               Reviewed;         185 AA.
AC   P65144; Q97R70;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Translation initiation factor IF-3 {ECO:0000255|HAMAP-Rule:MF_00080};
GN   Name=infC {ECO:0000255|HAMAP-Rule:MF_00080}; OrderedLocusNames=SP_0959;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: IF-3 binds to the 30S ribosomal subunit and shifts the
CC       equilibrum between 70S ribosomes and their 50S and 30S subunits in
CC       favor of the free subunits, thus enhancing the availability of 30S
CC       subunits on which protein synthesis initiation begins.
CC       {ECO:0000255|HAMAP-Rule:MF_00080}.
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00080}.
CC   -!- INTERACTION:
CC       P65144; Q97SE5: gatC; NbExp=2; IntAct=EBI-2207149, EBI-2207053;
CC       P65144; Q97NV3: groES; NbExp=2; IntAct=EBI-2207149, EBI-2206949;
CC       P65144; Q97S73: grpE; NbExp=2; IntAct=EBI-2207149, EBI-2207065;
CC       P65144; Q97SR4: uppS; NbExp=2; IntAct=EBI-2207149, EBI-2206983;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00080}.
CC   -!- SIMILARITY: Belongs to the IF-3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00080}.
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DR   EMBL; AE005672; AAK75080.1; -; Genomic_DNA.
DR   PIR; G95110; G95110.
DR   RefSeq; WP_000466297.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; P65144; -.
DR   SMR; P65144; -.
DR   IntAct; P65144; 4.
DR   STRING; 170187.SP_0959; -.
DR   EnsemblBacteria; AAK75080; AAK75080; SP_0959.
DR   KEGG; spn:SP_0959; -.
DR   eggNOG; COG0290; Bacteria.
DR   OMA; RNMIMFL; -.
DR   PhylomeDB; P65144; -.
DR   BioCyc; SPNE170187:G1FZB-987-MON; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.10.20.80; -; 1.
DR   Gene3D; 3.30.110.10; -; 1.
DR   HAMAP; MF_00080; IF_3; 1.
DR   InterPro; IPR036788; T_IF-3_C_sf.
DR   InterPro; IPR036787; T_IF-3_N_sf.
DR   InterPro; IPR019813; Translation_initiation_fac3_CS.
DR   InterPro; IPR001288; Translation_initiation_fac_3.
DR   InterPro; IPR019815; Translation_initiation_fac_3_C.
DR   InterPro; IPR019814; Translation_initiation_fac_3_N.
DR   PANTHER; PTHR10938; PTHR10938; 1.
DR   Pfam; PF00707; IF3_C; 1.
DR   Pfam; PF05198; IF3_N; 1.
DR   SUPFAM; SSF54364; SSF54364; 1.
DR   SUPFAM; SSF55200; SSF55200; 1.
DR   TIGRFAMs; TIGR00168; infC; 1.
DR   PROSITE; PS00938; IF3; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Initiation factor; Protein biosynthesis.
FT   CHAIN           1..185
FT                   /note="Translation initiation factor IF-3"
FT                   /id="PRO_0000177588"
SQ   SEQUENCE   185 AA;  21165 MW;  422496FBB9463732 CRC64;
     MFFSNKTKEV KTIAKQDLFI NDEIRVREVR LIGLEGEQLG IKPLSEAQAL ADNANVDLVL
     IQPQAKPPVA KIMDYGKFKF EYQKKQKEQR KKQSVVTVKE VRLSPTIDKG DFDTKLRNAR
     KFLEKGNKVK VSIRFKGRMI THKEIGAKVL AEFAEATQDI AIIEQRAKMD GRQMFMQLAP
     ATDKK