IF44L_MOUSE
ID IF44L_MOUSE Reviewed; 447 AA.
AC Q9BDB7; Q8SP46;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Interferon-induced protein 44-like;
DE Contains:
DE RecName: Full=Minor histocompatibility antigen HA-28;
DE Short=HLA-HA28;
DE AltName: Full=IFL8;
GN Name=Ifi44l; Synonyms=H28;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION,
RP TISSUE SPECIFICITY, AND INDUCTION.
RC STRAIN=BALB/c x BALB.B, and C57BL/6J; TISSUE=Spleen;
RX PubMed=11021531; DOI=10.1016/s1074-7613(00)00033-9;
RA Malarkannan S., Horng T., Eden P., Gonzalez F., Shih P., Brouwenstijn N.,
RA Klinge H., Christianson G., Roopenian D., Shastri N.;
RT "Differences that matter: major cytotoxic T cell-stimulating minor
RT histocompatibility antigens.";
RL Immunity 13:333-344(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, DISRUPTION PHENOTYPE, AND INDUCTION BY VIRAL INFECTION.
RX PubMed=32611756; DOI=10.1128/jvi.00297-20;
RA Busse D.C., Habgood-Coote D., Clare S., Brandt C., Bassano I., Kaforou M.,
RA Herberg J., Levin M., Eleouet J.F., Kellam P., Tregoning J.S.;
RT "Interferon-Induced Protein 44 and Interferon-Induced Protein 44-Like
RT Restrict Replication of Respiratory Syncytial Virus.";
RL J. Virol. 94:0-0(2020).
CC -!- FUNCTION: Type I interferon-stimulated gene (ISG) that plays a critical
CC role in antiviral and antibacterial activity. During bacterial
CC infection, promotes macrophage differentiation and facilitates
CC inflammatory cytokine secretion (By similarity). Plays a role in the
CC control of respiratory syncycial virus/RSV infection, reducing the
CC ability of the virus to replicate (PubMed:32611756). Acts as a feedback
CC regulator of IFN responses by negatively regulating IKBKB kinase
CC activity through interaction with FKBP5 (By similarity).
CC {ECO:0000250|UniProtKB:Q53G44, ECO:0000269|PubMed:32611756}.
CC -!- FUNCTION: Precursor of the histocompatibility antigen HA-28 in BALB.B
CC mice. More generally, minor histocompatibility antigens refer to
CC immunogenic peptide which, when complexed with MHC, can generate an
CC immune response after recognition by specific T-cells. The peptides are
CC derived from polymorphic intracellular proteins, which are cleaved by
CC normal pathways of antigen processing. The binding of these peptides to
CC MHC molecules and its expression on the cell surface can stimulate T-
CC cell responses and thereby trigger graft rejection or graft-versus-host
CC disease (GVHD). More specifically, HA-28 minor antigen is transcribed
CC in the BALB.B donor but not in host C57BL/6 cells. HA-28 is presented
CC to the donor BALB.B cell surface by Kb MHC. This complex HA-28/Kb MHC
CC elicits cytotoxic T-cell response in C57BL/6 mice immunized with BALB.B
CC spleen cells. It induces C57BL/6 mice cells recognition and lysis by
CC CD8 T-cell from BALB.B mice. {ECO:0000269|PubMed:11021531}.
CC -!- SUBUNIT: HA-28 antigen forms a complex with Kb MHC in BALB.B donor
CC cells. Interacts with FKBP5; this interaction modulates IKBKB and IKBKE
CC kinase activities (By similarity). {ECO:0000250|UniProtKB:Q53G44}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11021531}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BDB7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BDB7-2; Sequence=VSP_034010;
CC -!- TISSUE SPECIFICITY: Expressed on cells of the hematopoietic lineage.
CC Detected in transformed cell lines of the macrophage and B-cell
CC lineage. Expressed in spleen and bone marrow.
CC {ECO:0000269|PubMed:11021531}.
CC -!- INDUCTION: By respiratory syncytial virus/RSV (PubMed:32611756). HA-28
CC antigen is expressed after induction by inflammatory cytokines.
CC {ECO:0000269|PubMed:11021531, ECO:0000269|PubMed:32611756}.
CC -!- DISRUPTION PHENOTYPE: Deletion mutants result in elevated respiratory
CC syncycial virus/RSV infection in vitro. {ECO:0000269|PubMed:32611756}.
CC -!- SIMILARITY: Belongs to the IFI44 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK07660.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF336221; AAK07660.1; ALT_FRAME; mRNA.
DR EMBL; BC024930; AAH24930.1; -; mRNA.
DR RefSeq; NP_112735.1; NM_031367.1.
DR AlphaFoldDB; Q9BDB7; -.
DR STRING; 10090.ENSMUSP00000044765; -.
DR iPTMnet; Q9BDB7; -.
DR PhosphoSitePlus; Q9BDB7; -.
DR SwissPalm; Q9BDB7; -.
DR MaxQB; Q9BDB7; -.
DR PaxDb; Q9BDB7; -.
DR PRIDE; Q9BDB7; -.
DR ProteomicsDB; 267258; -. [Q9BDB7-1]
DR ProteomicsDB; 267259; -. [Q9BDB7-2]
DR DNASU; 15061; -.
DR GeneID; 15061; -.
DR KEGG; mmu:15061; -.
DR UCSC; uc029upc.1; mouse. [Q9BDB7-1]
DR CTD; 10964; -.
DR MGI; MGI:95975; Ifi44l.
DR eggNOG; ENOG502QQ57; Eukaryota.
DR InParanoid; Q9BDB7; -.
DR OrthoDB; 570957at2759; -.
DR PhylomeDB; Q9BDB7; -.
DR BioGRID-ORCS; 15061; 0 hits in 52 CRISPR screens.
DR PRO; PR:Q9BDB7; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q9BDB7; protein.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0051607; P:defense response to virus; ISO:MGI.
DR GO; GO:0006955; P:immune response; IDA:MGI.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR024644; IFI44_fam.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006571; TLDc_dom.
DR PANTHER; PTHR14241:SF2; PTHR14241:SF2; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51886; TLDC; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Reference proteome.
FT CHAIN 1..447
FT /note="Interferon-induced protein 44-like"
FT /id="PRO_0000337846"
FT PEPTIDE 66..73
FT /note="Minor histocompatibility antigen HA-28"
FT /id="PRO_0000342087"
FT DOMAIN 1..159
FT /note="TLDc"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01234"
FT VAR_SEQ 242..292
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034010"
FT CONFLICT 109
FT /note="E -> D (in Ref. 2; AAH24930)"
FT /evidence="ECO:0000305"
FT CONFLICT 150
FT /note="P -> L (in Ref. 2; AAH24930)"
FT /evidence="ECO:0000305"
FT CONFLICT 324
FT /note="H -> D (in Ref. 2; AAH24930)"
FT /evidence="ECO:0000305"
FT CONFLICT 370
FT /note="S -> N (in Ref. 2; AAH24930)"
FT /evidence="ECO:0000305"
FT CONFLICT 437
FT /note="P -> L (in Ref. 1; AAK07660)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 447 AA; 49680 MW; 71999CDDA5BE0AA2 CRC64;
MKVTARLTWI EEKILEKLLG NASLTLLYQS SAHKNCVSEM TQKYSLQGST MTVFHLEKDV
VVGVFILENF PRLVSEKPCT CAWFSLKRNN SSGISALFLN TKVIVDSEEL IIFSLDGLSL
SVTPLRGFTL ALNDTVMNGL ELNLGHGFLP VECEIFRVDG IKKNPSFIKK MVTAEQHRGK
LLSALRAYKP YKDLVSEVRI LLVGPVGSGK SSFFNSVKSA FQGHLTRQAI VGSDESSITK
QYRVYSIKDG KSGETLPFML CDSMGLEEGE EAGLCIDDIP HILQGCVPDR YQFNPCEPMK
PKHSPHAASP PLKDRIHCVA FVLHINSVNT LSDKMVAKLK KIRKDVVDCG IGYVALLTNV
EEYDEVLDDS FANMTETVTS LSQVQNVQKW LNIPIANILM VSNYASERRL EPMKDILVFA
ALRQMLRAAD DALEDLPLED TGNLAPF
