ID   IF4AX_DICDI             Reviewed;         248 AA.
AC   Q54CH6;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Putative eukaryotic initiation factor 4A-like protein;
GN   ORFNames=DDB_G0292914;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. eIF4A subfamily.
CC       {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AAFI02000197; EAL61006.1; -; Genomic_DNA.
DR   RefSeq; XP_629440.1; XM_629438.1.
DR   AlphaFoldDB; Q54CH6; -.
DR   SMR; Q54CH6; -.
DR   STRING; 44689.DDB0266390; -.
DR   PaxDb; Q54CH6; -.
DR   PRIDE; Q54CH6; -.
DR   EnsemblProtists; EAL61006; EAL61006; DDB_G0292914.
DR   GeneID; 8628959; -.
DR   KEGG; ddi:DDB_G0292914; -.
DR   dictyBase; DDB_G0292914; -.
DR   eggNOG; KOG0327; Eukaryota.
DR   HOGENOM; CLU_1121801_0_0_1; -.
DR   InParanoid; Q54CH6; -.
DR   PhylomeDB; Q54CH6; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0010494; C:cytoplasmic stress granule; IBA:GO_Central.
DR   GO; GO:0000932; C:P-body; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   GO; GO:0017148; P:negative regulation of translation; IBA:GO_Central.
DR   GO; GO:0033962; P:P-body assembly; IBA:GO_Central.
DR   GO; GO:0034063; P:stress granule assembly; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   5: Uncertain;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..248
FT                   /note="Putative eukaryotic initiation factor 4A-like
FT                   protein"
FT                   /id="PRO_0000327575"
FT   DOMAIN          45..239
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   MOTIF           14..42
FT                   /note="Q motif"
FT   MOTIF           185..188
FT                   /note="DEAD box"
FT   BINDING         58..65
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   248 AA;  28069 MW;  00021B034E49ACD9 CRC64;
     MSEGDLFLIS FLKVGFASLG LNEQLINNIK RYGITKLTPF QMEVIKEIKE NSNVIVDSIE
     GTGRTISLII GTLDKIDETK QQQEQEQQER QQTDQQFSFP QILMILPTKE LSQTTKVIYS
     SLGGGENNNN DFKVLSCIGG VKISMDIEIL KKGNTQILLG TPGRISDLFS RKRFDTDNIK
     ILVFDELDEI LSRGFECQLE DIIKPLNNNN NLQIIVSTSG INELTSNFIN TFIKIPKIIK
     SQQEPYKF