IF4E1_PEA
ID IF4E1_PEA Reviewed; 228 AA.
AC Q0GRC4; D9YZE9; Q0GRC6; Q0GRC7; Q0GRC8; Q6IZE4; Q6IZE5; Q6TEC4; X4XYN0;
AC X4XYN4; X4XYN8; X4XYP5; X4XYQ4; X4XYR3; X4Y582; X4Y586; X4Y589; X4Y7X3;
AC X4Y7Y3; X4Y7Y9; X4Y813; X4YKT5; X4YKV9; X4YKW5; X4YKY3; X4YKY6; X4YMK2;
AC X4YMP3;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 54.
DE RecName: Full=Eukaryotic translation initiation factor 4E-1 {ECO:0000303|Ref.3};
DE Short=eIF-4E-1 {ECO:0000303|Ref.3};
DE Short=eIF4E-1 {ECO:0000303|Ref.3};
DE AltName: Full=eIF-4F 25 kDa subunit {ECO:0000305};
DE AltName: Full=eIF-4F p26 subunit {ECO:0000305};
DE AltName: Full=mRNA cap-binding protein {ECO:0000303|Ref.3};
GN Name=eIF4E {ECO:0000303|Ref.3};
GN Synonyms=SBM-1 {ECO:0000303|Ref.3}, WLV {ECO:0000303|PubMed:17849710};
OS Pisum sativum (Garden pea).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Fabeae; Pisum.
OX NCBI_TaxID=3888;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLU-5; TRP-62; 73-ASP-ASP-74 DELINS
RP ALA-ALA; 73-ASP--SER-77 DELINS PRO-ASP-TRP-GLY; GLY-107 AND ASN-169,
RP FUNCTION, FUNCTION (MICROBIAL INFECTION), AND POLYMORPHISM.
RC STRAIN=cv. JI 1405, cv. JI 2009, and cv. PI 269818;
RX PubMed=15469495; DOI=10.1111/j.1365-313x.2004.02215.x;
RA Gao Z., Johansen E., Eyers S., Thomas C.L., Noel Ellis T.H., Maule A.J.;
RT "The potyvirus recessive resistance gene, sbm1, identifies a novel role for
RT translation initiation factor eIF4E in cell-to-cell trafficking.";
RL Plant J. 40:376-385(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, FUNCTION (MICROBIAL INFECTION),
RP VARIANTS SER-57; TRP-62; 58-SER--LEU-62 DELINS PRO-TRP-THR-PHE-TRP; TRP-62;
RP 73-ASP-ASP-74 DELINS ALA-ALA; 106-VAL-ARG-107 DELINS ALA-GLY; GLY-107;
RP SER-149; 169-LYS--ARG-171 DELINS ASN-VAL-GLY; ASN-169; PRO-201 AND ALA-206,
RP AND POLYMORPHISM.
RC STRAIN=cv. Bonneville, cv. Brutus, cv. Dark skinned Perfection,
RC cv. PI 193835, and cv. PI 347464;
RX PubMed=17849710; DOI=10.1094/mpmi-20-9-1075;
RA Bruun-Rasmussen M., Moeller I.S., Tulinius G., Hansen J.K.R., Lund O.S.,
RA Johansen I.E.;
RT "The same allele of translation initiation factor 4E mediates resistance
RT against two Potyvirus spp. in Pisum sativum.";
RL Mol. Plant Microbe Interact. 20:1075-1082(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS TRP-62; 73-ASP-ASP-74
RP DELINS ALA-ALA; GLY-107 AND ASN-169.
RC STRAIN=cv. Fjord, and cv. PI 193835;
RX AGRICOLA=IND44432414; DOI=10.1007/s11032-009-9383-7;
RA Smykal P., Safarova D., Navratil M., Dostalova R.;
RT "Marker assisted pea breeding: eIF4E allele specific markers to pea seed-
RT borne mosaic virus (PSbMV) resistance.";
RL Mol. Breed. 26:425-438(2010).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, FUNCTION (MICROBIAL
RP INFECTION), VARIANTS ILE-19; ALA-23; ASP-23; 24-ILE--ASN-28 DELINS
RP PHE-GLU-ASP-ASP-ASP; ALA-34; ALA-49; TRP-62; VAL-73; 73-ASP-ASP-74 DELINS
RP ALA-ALA; 73-ASP--SER-77 DELINS ALA-ALA-TRP-GLY-ARG; 73-ASP--SER-77 DELINS
RP PRO-ASP-TRP-GLY; ALA-74; CYS-86; GLY-107; PRO-108; ARG-115; TRP-149;
RP THR-163; ASN-169; 169-LYS-VAL-170 DELINS ASN-ALA; HIS-186; ILE-207; SER-215
RP AND 218-LEU-ASP-219 DELINS GLN-GLU, AND POLYMORPHISM.
RC STRAIN=cv. ATC-1044, cv. ATC-3275, cv. ATC-6927, cv. ATC-6931,
RC cv. ATC-7134, cv. ATC-7140, cv. ATC-7173, cv. CGN-3302, cv. CGN-3311,
RC cv. CGN-3319, cv. IPK-468, cv. IPK-477, cv. IPK-479, cv. JI 1007,
RC cv. JI 1010, cv. JI 1030, cv. JI 1085, cv. JI 1090, cv. JI 1091,
RC cv. JI 1104, cv. JI 1107, cv. JI 1108, cv. JI 1109, cv. JI 1121,
RC cv. JI 1194, cv. JI 1260, cv. JI 1370, cv. JI 1532, cv. JI 1546,
RC cv. JI 1632, cv. JI 1756, cv. JI 1758, cv. JI 1787, cv. JI 1788,
RC cv. JI 1790, cv. JI 182, cv. JI 1845, cv. JI 190, cv. JI 193, cv. JI 194,
RC cv. JI 205, cv. JI 2065, cv. JI 2571, cv. JI 2607, cv. JI 261, cv. JI 2630,
RC cv. JI 2643, cv. JI 2646, cv. JI 267, cv. JI 3001, cv. JI 3157, cv. JI 467,
RC cv. JI 967, cv. PI 116056, cv. PI 193584, cv. PI 193586, cv. PI 193835,
RC cv. PI 249645, cv. PI 269774, cv. PI 269818, cv. PI 347328, cv. PI 347422,
RC cv. PI 347464, cv. PI 347484, cv. PI 347492, cv. PI 347494, cv. PI 356991,
RC cv. PI 356992, cv. PI 357290, cv. PI 378158, cv. PI 505122, cv. PI 639981,
RC and cv. VIR 1589;
RX PubMed=24609094; DOI=10.1371/journal.pone.0090394;
RA Konecna E., Safarova D., Navratil M., Hanacek P., Coyne C., Flavell A.,
RA Vishnyakova M., Ambrose M., Redden R., Smykal P.;
RT "Geographical gradient of the eIF4E alleles conferring resistance to
RT potyviruses in pea (Pisum) germplasm.";
RL PLoS ONE 9:e90394-e90394(2014).
RN [5]
RP GENE FAMILY, AND REVIEW.
RX PubMed=24309680; DOI=10.1016/j.meegid.2013.11.024;
RA Moury B., Charron C., Janzac B., Simon V., Gallois J.L., Palloix A.,
RA Caranta C.;
RT "Evolution of plant eukaryotic initiation factor 4E (eIF4E) and potyvirus
RT genome-linked protein (VPg): a game of mirrors impacting resistance
RT spectrum and durability.";
RL Infect. Genet. Evol. 27:472-480(2014).
RN [6]
RP X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 52-228 IN COMPLEX WITH
RP 7-METHYLGUANOSINE, FUNCTION, FUNCTION (MICROBIAL INFECTION), INTERACTION
RP WITH POTYVIRUS VPG, VARIANTS GLU-5; TRP-62; 73-ASP-ASP-74 DELINS ALA-ALA;
RP 73-ASP--SER-77 DELINS PRO-ASP-TRP-GLY; GLY-107 AND ASN-169, SUBCELLULAR
RP LOCATION (MICROBIAL INFECTION), MUTAGENESIS OF PHE-63; ASP-64; THR-65;
RP PRO-66; ALA-67; ALA-68; LYS-69; SER-70; LYS-71; GLN-72; TRP-75; ASP-109;
RP TYR-111; PHE-113; LYS-120; TRP-121; GLU-122; GLY-165; VAL-167; VAL-170;
RP ARG-171; ARG-173; LYS-176; SER-178 AND TRP-180, AND POLYMORPHISM.
RC STRAIN=cv. JI 1405, and cv. JI 2009;
RX PubMed=21283665; DOI=10.1371/journal.pone.0015873;
RA Ashby J.A., Stevenson C.E.M., Jarvis G.E., Lawson D.M., Maule A.J.;
RT "Structure-based mutational analysis of eIF4E in relation to sbm1
RT resistance to pea seed-borne mosaic virus in pea.";
RL PLoS ONE 6:e15873-e15873(2011).
CC -!- FUNCTION: Component of the protein complex eIF4F, which is involved in
CC the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal
CC secondary structure and recruitment of mRNA to the ribosome
CC (PubMed:15469495, PubMed:21283665). Recognizes and binds the 7-
CC methylguanosine-containing mRNA cap during an early step in the
CC initiation of protein synthesis and facilitates ribosome binding by
CC inducing the unwinding of the mRNAs secondary structures
CC (PubMed:15469495, PubMed:21283665). Key component of recessive
CC resistance to potyviruses (PubMed:15469495, PubMed:17849710,
CC PubMed:21283665, PubMed:24609094). {ECO:0000269|PubMed:15469495,
CC ECO:0000269|PubMed:17849710, ECO:0000269|PubMed:21283665,
CC ECO:0000269|PubMed:24609094}.
CC -!- FUNCTION: (Microbial infection) Susceptibility host factor required for
CC viral infection by recruiting viral RNAs to the host ribosomal complex
CC via an interaction with viral genome-linked protein (VPg)
CC (PubMed:15469495, PubMed:17849710, PubMed:24609094, PubMed:21283665).
CC Seems also involved in virus movement from cell-to-cell
CC (PubMed:15469495). {ECO:0000269|PubMed:15469495,
CC ECO:0000269|PubMed:17849710, ECO:0000269|PubMed:21283665,
CC ECO:0000269|PubMed:24609094}.
CC -!- SUBUNIT: EIF4F is a multi-subunit complex, the composition of which
CC varies with external and internal environmental conditions. It is
CC composed of at least EIF4A, EIF4E and EIF4G. EIF4E is also known to
CC interact with other partners. In higher plants two isoforms of EIF4F
CC have been identified, named isoform EIF4F and isoform EIF(iso)4F.
CC Isoform EIF4F has subunits p220 and p26, whereas isoform EIF(iso)4F has
CC subunits p82 and p28. {ECO:0000250|UniProtKB:P29557}.
CC -!- SUBUNIT: (Microbial infection) Interacts with potyvirus viral genome-
CC linked protein (VPg); this interaction is possible in susceptible hosts
CC but impaired in resistant plants. {ECO:0000305|PubMed:15469495,
CC ECO:0000305|PubMed:17849710, ECO:0000305|PubMed:21283665,
CC ECO:0000305|PubMed:24609094}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21283665}. Cytoplasm
CC {ECO:0000269|PubMed:21283665}. Note=(Microbial infection) Binds to
CC potyvirus viral genome-linked protein (VPg) in the nucleus and with
CC potyvirus nuclear inclusion protein A (NIa-Pro) and nuclear inclusion
CC protein B (NIb) in the cytoplasm. {ECO:0000269|PubMed:21283665}.
CC -!- PTM: According to the redox status, the Cys-126-Cys-164 disulfide
CC bridge may have a role in regulating protein function by affecting its
CC ability to bind capped mRNA. {ECO:0000250|UniProtKB:P29557}.
CC -!- POLYMORPHISM: Variant present in the strain cv. PI 347464, allele A-5,
CC confers an increased resistance to pea seed-borne mosaic virus (PSbMV)
CC pathotype P1. {ECO:0000269|PubMed:24609094}.
CC -!- POLYMORPHISM: Variant present in the strain cv. JI 1546, allele A-2,
CC confers an increased resistance to pea seed-borne mosaic virus (PSbMV)
CC pathotype P1. {ECO:0000269|PubMed:24609094}.
CC -!- POLYMORPHISM: Variant present in the strain cv. JI 1787, allele 1,
CC confers an increased resistance to pea seed-borne mosaic virus (PSbMV)
CC pathotype P1. {ECO:0000269|PubMed:24609094}.
CC -!- POLYMORPHISM: Variant present in the strains cv. JI 1194, cv. CGN-3311,
CC cv. ATC-7140, cv. ATC-3275, cv. ATC-7134, cv. IPK-477 and cv. CGN-3319,
CC allele B-1, confers an increased resistance to pea seed-borne mosaic
CC virus (PSbMV) pathotype P1. {ECO:0000269|PubMed:24609094}.
CC -!- POLYMORPHISM: Variant present in the strain cv. CGN-3302, allele A-1,
CC confers an increased resistance to pea seed-borne mosaic virus (PSbMV)
CC pathotype P1. {ECO:0000269|PubMed:24609094}.
CC -!- POLYMORPHISM: Variant present in the strain cv. PI 269774, allele A-7,
CC confers an increased resistance to pea seed-borne mosaic virus (PSbMV)
CC pathotype P1. {ECO:0000269|PubMed:24609094}.
CC -!- POLYMORPHISM: Variant present in the strain cv. PI 347328, allele S-2,
CC confers susceptibility to pea seed-borne mosaic virus (PSbMV) pathotype
CC P1. {ECO:0000269|PubMed:24609094}.
CC -!- POLYMORPHISM: Variant present in the strain cv. JI 2646, allele S-7,
CC confers susceptibility to pea seed-borne mosaic virus (PSbMV) pathotype
CC P1. {ECO:0000269|PubMed:24609094}.
CC -!- POLYMORPHISM: Variant present in the strains cv. JI 1091 and JI 3001,
CC allele S-1, confers susceptibility to pea seed-borne mosaic virus
CC (PSbMV) pathotype P1. {ECO:0000269|PubMed:24609094}.
CC -!- POLYMORPHISM: Variant present in the strain cv. JI 1632, allele S-4,
CC confers susceptibility to pea seed-borne mosaic virus (PSbMV) pathotype
CC P1. {ECO:0000269|PubMed:24609094}.
CC -!- POLYMORPHISM: Variant present in the strain cv. JI 2630, allele S-1,
CC confers susceptibility to pea seed-borne mosaic virus (PSbMV) pathotype
CC P1. {ECO:0000269|PubMed:24609094}.
CC -!- POLYMORPHISM: Variant present in the strains cv. JI 2643, cv. Fjord,
CC cv. JI 261, cv. JI 194, cv. JI 205, cv. JI 1109, cv. JI 267, cv. PI
CC 505122, cv. PI 639981, cv. JI 1104, cv. JI 1108, cv. ATC-6927, cv. ATC-
CC 7173, cv. JI 1758, cv. JI 1030, cv. JI 190, cv. PI 357290, cv. JI 193,
CC cv. JI 2607, cv. JI 2571, cv. JI 1107, cv. JI 1085, cv. JI 2065, cv. JI
CC 1121, cv. JI 1756, cv. JI 182 and cv. JI 3157, alleles S-1, eIF4E(S)
CC and C-1, confers susceptibility to pea seed-borne mosaic virus (PSbMV).
CC {ECO:0000269|PubMed:15469495, ECO:0000269|PubMed:21283665,
CC ECO:0000269|PubMed:24609094}.
CC -!- POLYMORPHISM: Variant present in the strain cv. Dark skinned
CC Perfection, confers susceptibility to bean yellow mosaic virus (BYMV)
CC pathotype W. {ECO:0000269|PubMed:17849710}.
CC -!- POLYMORPHISM: Variant present in the strains cv. JI 2009, alleles
CC susceptible and SBM1, confers susceptibility to pea seed-borne mosaic
CC virus (PSbMV) pathotypes 1 and 4. {ECO:0000269|PubMed:15469495,
CC ECO:0000269|PubMed:21283665}.
CC -!- POLYMORPHISM: Variant present in the strain cv. JI 1405, allele
CC resistant-1, confers an increased resistance to pea seed-borne mosaic
CC virus (PSbMV) pathotype P1. {ECO:0000269|PubMed:15469495,
CC ECO:0000269|PubMed:21283665}.
CC -!- POLYMORPHISM: Variant present in the strain cv. PI 269818, alleles
CC resistant-2, sbm1, eIF4E(R) and A-6, confers an increased resistance to
CC pea seed-borne mosaic virus (PSbMV) pathotype P1.
CC {ECO:0000269|PubMed:15469495, ECO:0000269|PubMed:24609094}.
CC -!- POLYMORPHISM: Variant present in the strain cv. Bonneville, confers
CC susceptibility to bean yellow mosaic virus (BYMV) pathotype W.
CC {ECO:0000269|PubMed:17849710}.
CC -!- POLYMORPHISM: Variant present in the strain cv. Brutus, confers
CC susceptibility to bean yellow mosaic virus (BYMV) pathotype W.
CC {ECO:0000269|PubMed:17849710}.
CC -!- POLYMORPHISM: Variant present in the strain cv. JI 1007, allele S-5,
CC confers susceptibility to pea seed-borne mosaic virus (PSbMV) pathotype
CC P1. {ECO:0000269|PubMed:24609094}.
CC -!- POLYMORPHISM: Variant present in the strain cv. JI 1010, allele S-6,
CC confers susceptibility to pea seed-borne mosaic virus (PSbMV) pathotype
CC P1. {ECO:0000269|PubMed:24609094}.
CC -!- POLYMORPHISM: Variant present in the strains cv. PI 347422, cv. ATC-
CC 6931 and cv. PI 347484, allele S-3, confers susceptibility to pea seed-
CC borne mosaic virus (PSbMV) pathotype P1. {ECO:0000269|PubMed:24609094}.
CC -!- POLYMORPHISM: Variant present in the strain cv. JI 1845, allele S-1,
CC confers susceptibility to pea seed-borne mosaic virus (PSbMV) pathotype
CC P1. {ECO:0000269|PubMed:24609094}.
CC -!- POLYMORPHISM: Variant present in the strain cv. JI 1090, allele B-3,
CC confers an increased resistance to pea seed-borne mosaic virus (PSbMV)
CC pathotype P1. {ECO:0000269|PubMed:24609094}.
CC -!- POLYMORPHISM: Variant present in the strain cv. JI 1370, allele B-2,
CC confers an increased resistance to pea seed-borne mosaic virus (PSbMV)
CC pathotype P1. {ECO:0000269|PubMed:24609094}.
CC -!- POLYMORPHISM: Variant present in the strain cv. PI 378158, allele A-4,
CC confers an increased resistance to pea seed-borne mosaic virus (PSbMV)
CC pathotype P1. {ECO:0000269|PubMed:24609094}.
CC -!- POLYMORPHISM: Variant present in the strain cv. VIR 1589, allele C-2,
CC confers an increased resistance to pea seed-borne mosaic virus (PSbMV)
CC pathotype P1. {ECO:0000269|PubMed:24609094}.
CC -!- MISCELLANEOUS: Displayed sequence is in strains cv. JI 967, cv. IPK-
CC 468, cv. JI 1788, cv. IPK-479, cv. PI 193586, cv. PI 193835, cv. PI
CC 347494, cv. JI 467, cv. JI 1260, cv. JI 1790, cv. ATC-1044, cv. PI
CC 116056, cv. PI 193835, cv. PI 356991, cv. PI 356992, cv. PI 347464, cv.
CC PI 249645, cv. PI 193584 and allele A-1 which confers resistance to
CC bean yellow mosaic virus (BYMV) pathotype W and to pea seed-borne
CC mosaic virus (PsBMV). {ECO:0000305|PubMed:17849710,
CC ECO:0000305|PubMed:24609094, ECO:0000305|Ref.3}.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4E family.
CC {ECO:0000305}.
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DR EMBL; AY423375; AAR04332.2; -; mRNA.
DR EMBL; AY611423; AAT44121.1; -; mRNA.
DR EMBL; AY611425; AAT44122.1; -; mRNA.
DR EMBL; DQ641470; ABG35116.1; -; mRNA.
DR EMBL; DQ641471; ABG35117.1; -; mRNA.
DR EMBL; DQ641472; ABG35118.1; -; mRNA.
DR EMBL; DQ641473; ABG35119.1; -; mRNA.
DR EMBL; DQ641474; ABG35120.1; -; mRNA.
DR EMBL; GU289734; ADK97766.1; -; Genomic_DNA.
DR EMBL; GU289735; ADK97767.1; -; Genomic_DNA.
DR EMBL; KF053431; AHV79358.1; -; Genomic_DNA.
DR EMBL; KF053432; AHV79359.1; -; Genomic_DNA.
DR EMBL; KF053433; AHV79360.1; -; Genomic_DNA.
DR EMBL; KF053434; AHV79361.1; -; Genomic_DNA.
DR EMBL; KF053435; AHV79362.1; -; Genomic_DNA.
DR EMBL; KF053436; AHV79363.1; -; Genomic_DNA.
DR EMBL; KF053437; AHV79364.1; -; Genomic_DNA.
DR EMBL; KF053438; AHV79365.1; -; Genomic_DNA.
DR EMBL; KF053439; AHV79366.1; -; Genomic_DNA.
DR EMBL; KF053440; AHV79367.1; -; Genomic_DNA.
DR EMBL; KF053441; AHV79368.1; -; Genomic_DNA.
DR EMBL; KF053442; AHV79369.1; -; Genomic_DNA.
DR EMBL; KF053443; AHV79370.1; -; Genomic_DNA.
DR EMBL; KF053444; AHV79371.1; -; Genomic_DNA.
DR EMBL; KF053445; AHV79372.1; -; Genomic_DNA.
DR EMBL; KF053446; AHV79373.1; -; Genomic_DNA.
DR EMBL; KF053447; AHV79374.1; -; Genomic_DNA.
DR EMBL; KF053448; AHV79375.1; -; Genomic_DNA.
DR EMBL; KF053449; AHV79376.1; -; Genomic_DNA.
DR EMBL; KF053450; AHV79377.1; -; Genomic_DNA.
DR EMBL; KF053451; AHV79378.1; -; Genomic_DNA.
DR EMBL; KF053452; AHV79379.1; -; Genomic_DNA.
DR EMBL; KF053453; AHV79380.1; -; Genomic_DNA.
DR EMBL; KF053454; AHV79381.1; -; Genomic_DNA.
DR EMBL; KF053455; AHV79382.1; -; Genomic_DNA.
DR EMBL; KF981386; AHV79383.1; -; Genomic_DNA.
DR EMBL; KF981387; AHV79384.1; -; Genomic_DNA.
DR EMBL; KF981388; AHV79385.1; -; Genomic_DNA.
DR EMBL; KF981389; AHV79386.1; -; Genomic_DNA.
DR EMBL; KF981390; AHV79387.1; -; Genomic_DNA.
DR EMBL; KF981391; AHV79388.1; -; Genomic_DNA.
DR EMBL; KF981392; AHV79389.1; -; Genomic_DNA.
DR EMBL; KF981393; AHV79390.1; -; Genomic_DNA.
DR EMBL; KF981394; AHV79391.1; -; Genomic_DNA.
DR EMBL; KF981395; AHV79392.1; -; Genomic_DNA.
DR EMBL; KF981396; AHV79393.1; -; Genomic_DNA.
DR EMBL; KF981397; AHV79394.1; -; Genomic_DNA.
DR EMBL; KF981398; AHV79395.1; -; Genomic_DNA.
DR EMBL; KF981399; AHV79396.1; -; Genomic_DNA.
DR EMBL; KF981400; AHV79397.1; -; Genomic_DNA.
DR EMBL; KF981401; AHV79398.1; -; Genomic_DNA.
DR EMBL; KF981402; AHV79399.1; -; Genomic_DNA.
DR EMBL; KF981403; AHV79400.1; -; Genomic_DNA.
DR EMBL; KF981404; AHV79401.1; -; Genomic_DNA.
DR EMBL; KF981405; AHV79402.1; -; Genomic_DNA.
DR EMBL; KF981406; AHV79403.1; -; Genomic_DNA.
DR EMBL; KF981407; AHV79404.1; -; Genomic_DNA.
DR EMBL; KF981408; AHV79405.1; -; Genomic_DNA.
DR EMBL; KF981409; AHV79406.1; -; Genomic_DNA.
DR EMBL; KF981410; AHV79407.1; -; Genomic_DNA.
DR EMBL; KF981411; AHV79408.1; -; Genomic_DNA.
DR EMBL; KF981412; AHV79409.1; -; Genomic_DNA.
DR EMBL; KF981413; AHV79410.1; -; Genomic_DNA.
DR EMBL; KF981414; AHV79411.1; -; Genomic_DNA.
DR EMBL; KF981415; AHV79412.1; -; Genomic_DNA.
DR EMBL; KF981416; AHV79413.1; -; Genomic_DNA.
DR EMBL; KF981417; AHV79414.1; -; Genomic_DNA.
DR EMBL; KF981418; AHV79415.1; -; Genomic_DNA.
DR EMBL; KF981419; AHV79416.1; -; Genomic_DNA.
DR EMBL; KF981420; AHV79417.1; -; Genomic_DNA.
DR EMBL; KF981421; AHV79418.1; -; Genomic_DNA.
DR EMBL; KF981422; AHV79419.1; -; Genomic_DNA.
DR EMBL; KF981423; AHV79420.1; -; Genomic_DNA.
DR EMBL; KF981424; AHV79421.1; -; Genomic_DNA.
DR EMBL; KF981425; AHV79422.1; -; Genomic_DNA.
DR EMBL; KF981426; AHV79423.1; -; Genomic_DNA.
DR EMBL; KF981427; AHV79424.1; -; Genomic_DNA.
DR EMBL; KF981428; AHV79425.1; -; Genomic_DNA.
DR EMBL; KF981429; AHV79426.1; -; Genomic_DNA.
DR EMBL; KF981430; AHV79427.1; -; Genomic_DNA.
DR EMBL; KF981431; AHV79428.1; -; Genomic_DNA.
DR EMBL; KF981432; AHV79429.1; -; Genomic_DNA.
DR EMBL; KF981433; AHV79430.1; -; Genomic_DNA.
DR PDB; 2WMC; X-ray; 2.20 A; A/B/C/D/E/F/G/H=51-228.
DR PDBsum; 2WMC; -.
DR SMR; Q0GRC4; -.
DR EnsemblPlants; Psat1g192480.1; Psat1g192480.1.cds; Psat1g192480.
DR Gramene; Psat1g192480.1; Psat1g192480.1.cds; Psat1g192480.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IDA:UniProtKB.
DR GO; GO:0003743; F:translation initiation factor activity; IDA:UniProtKB.
DR GO; GO:0051607; P:defense response to virus; IDA:UniProtKB.
DR GO; GO:0006413; P:translational initiation; IDA:UniProtKB.
DR Gene3D; 3.30.760.10; -; 1.
DR InterPro; IPR023398; TIF_eIF4e-like.
DR InterPro; IPR001040; TIF_eIF_4E.
DR InterPro; IPR019770; TIF_eIF_4E_CS.
DR PANTHER; PTHR11960; PTHR11960; 1.
DR Pfam; PF01652; IF4E; 1.
DR SUPFAM; SSF55418; SSF55418; 1.
DR PROSITE; PS00813; IF4E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Disulfide bond; Host-virus interaction;
KW Initiation factor; Nucleus; Plant defense; Protein biosynthesis;
KW RNA-binding; Translation regulation.
FT CHAIN 1..228
FT /note="Eukaryotic translation initiation factor 4E-1"
FT /id="PRO_0000454069"
FT REGION 53..56
FT /note="EIF4G-binding"
FT /evidence="ECO:0000250|UniProtKB:Q00LS8"
FT REGION 63..99
FT /note="EIF4G-binding"
FT /evidence="ECO:0000250|UniProtKB:Q00LS8"
FT REGION 147..156
FT /note="EIF4G-binding"
FT /evidence="ECO:0000250|UniProtKB:Q00LS8"
FT BINDING 71..76
FT /ligand="mRNA"
FT /ligand_id="ChEBI:CHEBI:33699"
FT /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT /ligand_part_id="ChEBI:CHEBI:74429"
FT /ligand_part_note="m7GTP residue in mRNA cap"
FT /evidence="ECO:0000269|PubMed:21283665,
FT ECO:0007744|PDB:2WMC"
FT BINDING 103
FT /ligand="mRNA"
FT /ligand_id="ChEBI:CHEBI:33699"
FT /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT /ligand_part_id="ChEBI:CHEBI:74429"
FT /ligand_part_note="m7GTP residue in mRNA cap"
FT /evidence="ECO:0000250|UniProtKB:P29557"
FT BINDING 121..122
FT /ligand="mRNA"
FT /ligand_id="ChEBI:CHEBI:33699"
FT /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT /ligand_part_id="ChEBI:CHEBI:74429"
FT /ligand_part_note="m7GTP residue in mRNA cap"
FT /evidence="ECO:0000269|PubMed:21283665,
FT ECO:0007744|PDB:2WMC"
FT BINDING 171..176
FT /ligand="mRNA"
FT /ligand_id="ChEBI:CHEBI:33699"
FT /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT /ligand_part_id="ChEBI:CHEBI:74429"
FT /ligand_part_note="m7GTP residue in mRNA cap"
FT /evidence="ECO:0000269|PubMed:21283665,
FT ECO:0007744|PDB:2WMC"
FT BINDING 216..220
FT /ligand="mRNA"
FT /ligand_id="ChEBI:CHEBI:33699"
FT /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT /ligand_part_id="ChEBI:CHEBI:74429"
FT /ligand_part_note="m7GTP residue in mRNA cap"
FT /evidence="ECO:0000269|PubMed:21283665,
FT ECO:0007744|PDB:2WMC"
FT DISULFID 126..164
FT /evidence="ECO:0000250|UniProtKB:Q00LS8"
FT VARIANT 5
FT /note="D -> E (in strain: PI 269818, alleles resistant-2,
FT sbm1, eIF4E(R) and A-6. In strain: JI 1405, allele
FT resistant-1. In strain: JI 2009, alleles susceptible and
FT SBM1)"
FT /evidence="ECO:0000269|PubMed:15469495,
FT ECO:0000269|PubMed:21283665"
FT VARIANT 19
FT /note="N -> I (in strain: VIR 1589, allele C-2)"
FT /evidence="ECO:0000269|PubMed:24609094"
FT VARIANT 23
FT /note="V -> A (in strain: PI 378158, allele A-4. In strain:
FT JI 1370, allele B-2)"
FT /evidence="ECO:0000269|PubMed:24609094"
FT VARIANT 23
FT /note="V -> D (in strain: JI 1090, alleles B-3)"
FT /evidence="ECO:0000269|PubMed:24609094"
FT VARIANT 24..28
FT /note="IEDDN -> FEDDD (in strain: JI 1845, allele S-1)"
FT /evidence="ECO:0000269|PubMed:24609094"
FT VARIANT 34
FT /note="E -> A (in strain: PI 347492. In strain: PI 347422,
FT ATC-6931 and PI 347484, allele S-3)"
FT /evidence="ECO:0000269|PubMed:24609094"
FT VARIANT 49
FT /note="V -> A (in strain: JI 1010, allele S-6. In strain:
FT JI 1007, allele S-5. In strain: JI 1090, allele B-3. In
FT strain: JI 1370, allele B-2)"
FT /evidence="ECO:0000269|PubMed:24609094"
FT VARIANT 57
FT /note="N -> S (in strain: Brutus)"
FT /evidence="ECO:0000269|PubMed:17849710"
FT VARIANT 58..62
FT /note="SWTFL -> PWTFW (in strain: Bonneville)"
FT /evidence="ECO:0000269|PubMed:17849710"
FT VARIANT 62
FT /note="L -> W (in strain: PI 269818, alleles resistant-2,
FT sbm1, eIF4E(R) and A-6. In strain: JI 2009, alleles SBM1
FT and susceptible. In strain: Dark skinned Perfection. In
FT strain: Brutus. In strain: JI 2643, Fjord, JI 261, JI 194,
FT JI 205, JI 1109, JI 267, PI 505122, PI 639981, JI 1104, JI
FT 1108, ATC-6927, ATC-7173, JI 1758, JI 1030, JI 190, PI
FT 357290, JI 193, JI 2607, JI 2571, JI 1107, JI 1085, JI
FT 2065, JI 1121, JI 1756, JI 182 and JI 3157, alleles S-1,
FT eIF4E(S) and C-1. In strain: VIR 1589, allele C-2. In
FT strain: JI 2630, allele S-1. In strain: JI 1632, allele S-
FT 4. In strain: JI 1091 and JI 3001, allele S-1. In strain:
FT JI 1010, allele S-6. In strain: JI 1007, allele S-5. In
FT strain: JI 2646, allele S-7. In strain: JI 1845, allele S-
FT 1. In strain: PI 347328, allele S-2. In strain: PI 347422,
FT ATC-6931 and PI 347484, allele S-3. In strain: PI 269774,
FT allele A-7. In strain: CGN-3302, allele A-1. In strain: JI
FT 1194, CGN-3311, ATC-7140, ATC-3275, ATC-7134, IPK-477 and
FT CGN-3319, allele B-1. In strain: JI 1090, allele B-3. In
FT strain: JI 1370, allele B-2)"
FT /evidence="ECO:0000269|PubMed:15469495,
FT ECO:0000269|PubMed:17849710, ECO:0000269|PubMed:21283665,
FT ECO:0000269|PubMed:24609094, ECO:0000269|Ref.3"
FT VARIANT 73..77
FT /note="DDWGS -> AAWGR (in strain: PI 347328, allele S-2)"
FT /evidence="ECO:0000269|PubMed:24609094"
FT VARIANT 73..77
FT /note="DDWGS -> PDWG (in strain: PI 269818, alleles
FT resistant-2, sbm1, eIF4E(R) and A-6. In strain: PI 269774,
FT allele A-7)"
FT /evidence="ECO:0000269|PubMed:15469495,
FT ECO:0000269|PubMed:21283665, ECO:0000269|PubMed:24609094"
FT VARIANT 73..74
FT /note="DD -> AA (in strain: JI 2009, alleles susceptible
FT and SBM1. In strain: Dark skinned Perfection. In strain:
FT Bonneville. In strain: Brutus. In strain: JI 2643, Fjord,
FT JI 261, JI 194, JI 205, JI 1109, JI 267, PI 505122, PI
FT 639981, JI 1104, JI 1108, ATC-6927, ATC-7173, JI 1758, JI
FT 1030, JI 190, PI 357290, JI 193, JI 2607, JI 2571, JI 1107,
FT JI 1085, JI 2065, JI 1121, JI 1756, JI 182 and JI 3157,
FT alleles S-1, eIF4E(S) and C-1. In strain: VIR 1589, allele
FT C-2. In strain: JI 2630, allele S-1. In strain: JI 1632,
FT allele S-4. In strain: JI 1091 and JI 3001, allele S-1. In
FT strain: JI 1010, allele S-6. In strain: JI 1007, allele S-
FT 5. In strain: JI 2646, allele S-7. In strain: JI 1845,
FT allele S-1. In strain: PI 347422, ATC-6931 and PI 347484,
FT allele S-3. In strain: JI 1194, CGN-3311, ATC-7140, ATC-
FT 3275, ATC-7134, IPK-477 and CGN-3319, allele B-1. In
FT strain: JI 1090, allele B-3. In strain: JI 1370, allele B-
FT 2)"
FT /evidence="ECO:0000269|PubMed:15469495,
FT ECO:0000269|PubMed:17849710, ECO:0000269|PubMed:21283665,
FT ECO:0000269|PubMed:24609094, ECO:0000269|Ref.3"
FT VARIANT 73
FT /note="D -> V (in strain: CGN-3302, allele A-1)"
FT /evidence="ECO:0000269|PubMed:24609094"
FT VARIANT 74
FT /note="D -> A (in strain: JI 1787, allele 1)"
FT /evidence="ECO:0000269|PubMed:24609094"
FT VARIANT 86
FT /note="S -> C (in strain: JI 2646, allele S-7)"
FT /evidence="ECO:0000269|PubMed:24609094"
FT VARIANT 106..107
FT /note="VR -> AG (in strain: Dark skinned Perfection)"
FT /evidence="ECO:0000269|PubMed:17849710"
FT VARIANT 107
FT /note="R -> G (in strain: PI 269818, alleles resistant-2,
FT sbm1, eIF4E(R) and A-6. In strain: JI 2009, alleles
FT susceptible and SBM1. In strain: Bonneville. In strain:
FT Brutus. In strain: JI 2643, Fjord, JI 261, JI 194, JI 205,
FT JI 1109, JI 267, PI 505122, PI 639981, JI 1104, JI 1108,
FT ATC-6927, ATC-7173, JI 1758, JI 1030, JI 190, PI 357290, JI
FT 193, JI 2607, JI 2571, JI 1107, JI 1085, JI 2065, JI 1121,
FT JI 1756, JI 182 and JI 3157, alleles S-1, eIF4E(S) and C-1.
FT In strain: VIR 1589, allele C-2. In strain: JI 2630, allele
FT S-1. In strain: JI 1632, allele S-4. In strain: JI 1091 and
FT JI 3001, allele S-1. In strain: JI 1010, allele S-6. In
FT strain: JI 1007, allele S-5. In strain: JI 2646, allele S-
FT 7. In strain: JI 1845, allele S-1. In strain: PI 347328,
FT allele S-2. In strain: PI 347422, ATC-6931 and PI 347484,
FT allele S-3. In strain: PI 269774, allele A-7. In strain: JI
FT 1194, CGN-3311, ATC-7140, ATC-3275, ATC-7134, IPK-477 and
FT CGN-3319, allele B-1. In strain: JI 1090, allele B-3. In
FT strain: JI 1370, allele B-2)"
FT /evidence="ECO:0000269|PubMed:15469495,
FT ECO:0000269|PubMed:17849710, ECO:0000269|PubMed:21283665,
FT ECO:0000269|PubMed:24609094, ECO:0000269|Ref.3"
FT VARIANT 108
FT /note="A -> P (in strain: PI 347464, allele A-5)"
FT /evidence="ECO:0000269|PubMed:24609094"
FT VARIANT 115
FT /note="H -> R (in strain: PI 347464, allele A-5)"
FT /evidence="ECO:0000269|PubMed:24609094"
FT VARIANT 149
FT /note="L -> S (in strain: Dark skinned Perfection)"
FT /evidence="ECO:0000269|PubMed:17849710"
FT VARIANT 149
FT /note="L -> W (in strain: JI 1007, allele S-5)"
FT /evidence="ECO:0000269|PubMed:24609094"
FT VARIANT 163
FT /note="I -> T (in strain: PI 347328, allele S-2)"
FT /evidence="ECO:0000269|PubMed:24609094"
FT VARIANT 169..171
FT /note="KVR -> NVG (in strain: Brutus)"
FT /evidence="ECO:0000269|PubMed:17849710"
FT VARIANT 169..170
FT /note="KV -> NA (in strain: CGN-3302, allele A-1)"
FT /evidence="ECO:0000269|PubMed:24609094"
FT VARIANT 169
FT /note="K -> N (in strain: PI 269818, alleles resistant-2,
FT sbm1, eIF4E(R) and A-6. In strain: JI 2009, alleles
FT susceptible and SBM1. In strain: Dark skinned Perfection.
FT In strain: Bonneville. In strain: JI 2643, Fjord, JI 261,
FT JI 194, JI 205, JI 1109, JI 267, PI 505122, PI 639981, JI
FT 1104, JI 1108, ATC-6927, ATC-7173, JI 1758, JI 1030, JI
FT 190, PI 357290, JI 193, JI 2607, JI 2571, JI 1107, JI 1085,
FT JI 2065, JI 1121, JI 1756, JI 182 and JI 3157, alleles S-1,
FT eIF4E(S) and C-1. In strain: VIR 1589, allele C-2. In
FT strain: JI 2630, allele S-1. In strain: JI 1632, allele S-
FT 4. In strain: JI 1091 and JI 3001, allele S-1. In strain:
FT JI 1010, allele S-6. In strain: JI 1007, allele S-5. In
FT strain: JI 2646, allele S-7. In strain: JI 1845, allele S-
FT 1. In strain: PI 347328, allele S-2. In strain: PI 347422,
FT ATC-6931 and PI 347484, allele S-3. In strain: JI 1194,
FT CGN-3311, ATC-7140, ATC-3275, ATC-7134, IPK-477 and CGN-
FT 3319, allele B-1. In strain: JI 1090, allele B-3. In
FT strain: JI 1370, allele B-2)"
FT /evidence="ECO:0000269|PubMed:15469495,
FT ECO:0000269|PubMed:17849710, ECO:0000269|PubMed:21283665,
FT ECO:0000269|PubMed:24609094, ECO:0000269|Ref.3"
FT VARIANT 186
FT /note="N -> H (in strain: JI 1546, allele A-2)"
FT /evidence="ECO:0000269|PubMed:24609094"
FT VARIANT 201
FT /note="L -> P (in strain: Dark skinned Perfection)"
FT /evidence="ECO:0000269|PubMed:17849710"
FT VARIANT 206
FT /note="T -> A (in strain: Dark skinned Perfection)"
FT /evidence="ECO:0000269|PubMed:17849710"
FT VARIANT 207
FT /note="M -> I (in strain: JI 1632, allele S-4. In strain:
FT JI 1194, CGN-3311, ATC-7140, ATC-3275, ATC-7134, IPK-477
FT and CGN-3319, allele B-1)"
FT /evidence="ECO:0000269|PubMed:24609094"
FT VARIANT 215
FT /note="A -> S (in strain: JI 1532. In strain: VIR 1589,
FT allele C-2. In strain: JI 2630, allele S-1. In strain: JI
FT 1787, allele A-1. In strain: JI 1546, allele A-2)"
FT /evidence="ECO:0000269|PubMed:24609094"
FT VARIANT 218..219
FT /note="LD -> QE (in strain: JI 1194, CGN-3311, ATC-7140,
FT ATC-3275, ATC-7134, IPK-477 and CGN-3319, allele B-1)"
FT /evidence="ECO:0000269|PubMed:24609094"
FT MUTAGEN 63
FT /note="F->A: Resistance to pea seed-borne mosaic virus
FT (PSbMV) and reduced translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 64
FT /note="D->A: Susceptibility to pea seed-borne mosaic virus
FT (PSbMV) and normal translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 65
FT /note="T->Q: Susceptibility to pea seed-borne mosaic virus
FT (PSbMV) and normal translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 66
FT /note="P->A: Susceptibility to pea seed-borne mosaic virus
FT (PSbMV) and normal translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 67
FT /note="A->E: Partial susceptibility to pea seed-borne
FT mosaic virus (PSbMV) and normal translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 68
FT /note="A->E: Susceptibility to pea seed-borne mosaic virus
FT (PSbMV) and normal translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 69
FT /note="K->A: Susceptibility to pea seed-borne mosaic virus
FT (PSbMV) and normal translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 70
FT /note="S->A: Resistance to pea seed-borne mosaic virus
FT (PSbMV) and normal translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 71
FT /note="K->A: Resistance to pea seed-borne mosaic virus
FT (PSbMV) and normal translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 72
FT /note="Q->A: Susceptibility to pea seed-borne mosaic virus
FT (PSbMV) and normal translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 75
FT /note="W->A: Resistance to pea seed-borne mosaic virus
FT (PSbMV) and altered translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 75
FT /note="W->F: Susceptibility to pea seed-borne mosaic virus
FT (PSbMV) and slightly reduced translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 109
FT /note="D->A: Partial susceptibility to pea seed-borne
FT mosaic virus (PSbMV) and normal translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 111
FT /note="Y->A: Susceptibility to pea seed-borne mosaic virus
FT (PSbMV) and slightly reduced translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 113
FT /note="F->A: Partial susceptibility to pea seed-borne
FT mosaic virus (PSbMV) and altered translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 120
FT /note="K->A: Susceptibility to pea seed-borne mosaic virus
FT (PSbMV) and normal translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 121
FT /note="W->A,F: Resistance to pea seed-borne mosaic virus
FT (PSbMV) and altered translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 122
FT /note="E->A: Altered translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 165
FT /note="G->A: Resistance to pea seed-borne mosaic virus
FT (PSbMV) and altered translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 167
FT /note="V->A: Resistance to pea seed-borne mosaic virus
FT (PSbMV) and normal translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 170
FT /note="V->A: Susceptibility to pea seed-borne mosaic virus
FT (PSbMV) and normal translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 171
FT /note="R->A: Resistance to pea seed-borne mosaic virus
FT (PSbMV) and altered translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 173
FT /note="R->A: Susceptibility to pea seed-borne mosaic virus
FT (PSbMV) and normal translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 176
FT /note="K->A: Susceptibility to pea seed-borne mosaic virus
FT (PSbMV) and slightly reduced translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 178
FT /note="S->E: Susceptibility to pea seed-borne mosaic virus
FT (PSbMV) and altered translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT MUTAGEN 180
FT /note="W->A: Resistance to pea seed-borne mosaic virus
FT (PSbMV) and altered translation activation."
FT /evidence="ECO:0000269|PubMed:21283665"
FT STRAND 54..64
FT /evidence="ECO:0007829|PDB:2WMC"
FT HELIX 66..69
FT /evidence="ECO:0007829|PDB:2WMC"
FT TURN 75..78
FT /evidence="ECO:0007829|PDB:2WMC"
FT STRAND 80..87
FT /evidence="ECO:0007829|PDB:2WMC"
FT HELIX 88..95
FT /evidence="ECO:0007829|PDB:2WMC"
FT HELIX 101..103
FT /evidence="ECO:0007829|PDB:2WMC"
FT STRAND 109..114
FT /evidence="ECO:0007829|PDB:2WMC"
FT TURN 124..128
FT /evidence="ECO:0007829|PDB:2WMC"
FT STRAND 130..137
FT /evidence="ECO:0007829|PDB:2WMC"
FT HELIX 142..153
FT /evidence="ECO:0007829|PDB:2WMC"
FT HELIX 160..162
FT /evidence="ECO:0007829|PDB:2WMC"
FT STRAND 163..170
FT /evidence="ECO:0007829|PDB:2WMC"
FT STRAND 172..182
FT /evidence="ECO:0007829|PDB:2WMC"
FT HELIX 187..201
FT /evidence="ECO:0007829|PDB:2WMC"
FT STRAND 207..211
FT /evidence="ECO:0007829|PDB:2WMC"
FT HELIX 212..215
FT /evidence="ECO:0007829|PDB:2WMC"
FT STRAND 225..228
FT /evidence="ECO:0007829|PDB:2WMC"
SQ SEQUENCE 228 AA; 26095 MW; 1DA68639CCDCFE2A CRC64;
MVVEDTPKSI ITDDQITTNP NRVIEDDNNL EEGEILDEDD SSATSKPVVH QPHLLENSWT
FLFDTPAAKS KQDDWGSSMR PIYTFSTVEE FWSIYNNIHH PGKLAVRADF YCFKHKIEPK
WEDPICANGG KWTANYPKGK SDTSWLYTLL AMIGEQFDHG DEICGAVVKV RGRAEKISIW
TKNASNEAAQ VSIGKQWKEF LDYNETMGFI FHDDARKLDR NAKNKYVV
