ID   IF4E2_MAIZE             Reviewed;         216 AA.
AC   O81482;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Eukaryotic translation initiation factor isoform 4E-2;
DE            Short=eIF(iso)-4E-2;
DE            Short=eIF(iso)4E-2;
DE   AltName: Full=eIF-(iso)4F 25 kDa subunit;
DE   AltName: Full=eIF-(iso)4F p28 subunit;
DE   AltName: Full=mRNA cap-binding protein;
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Root;
RX   PubMed=10417723; DOI=10.1046/j.1365-313x.1999.00489.x;
RA   Manjunath S., Williams A.J., Bailey-Serres J.;
RT   "Oxygen deprivation stimulates Ca2+-mediated phosphorylation of mRNA cap-
RT   binding protein eIF4E in maize roots.";
RL   Plant J. 19:21-30(1999).
CC   -!- FUNCTION: Recognizes and binds the 7-methylguanosine-containing mRNA
CC       cap during an early step in the initiation of protein synthesis and
CC       facilitates ribosome binding by inducing the unwinding of the mRNAs
CC       secondary structures.
CC   -!- SUBUNIT: EIF4F is a multi-subunit complex, the composition of which
CC       varies with external and internal environmental conditions. It is
CC       composed of at least EIF4A, EIF4E and EIF4G. EIF4E is also known to
CC       interact with other partners. In higher plants two isoforms of EIF4F
CC       have been identified, named isoform EIF4F and isoform EIF(iso)4F.
CC       Isoform EIF4F has subunits p220 and p26, whereas isoform EIF(iso)4F has
CC       subunits p82 and p28.
CC   -!- PTM: According to the redox status, the Cys-113-Cys-152 disulfide
CC       bridge may have a role in regulating protein function by affecting its
CC       ability to bind capped mRNA. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4E family.
CC       {ECO:0000305}.
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DR   EMBL; AF076955; AAC27715.1; -; mRNA.
DR   PIR; T01687; T01687.
DR   RefSeq; NP_001104917.1; NM_001111447.1.
DR   AlphaFoldDB; O81482; -.
DR   SMR; O81482; -.
DR   STRING; 4577.GRMZM2G022019_P01; -.
DR   PaxDb; O81482; -.
DR   PRIDE; O81482; -.
DR   EnsemblPlants; Zm00001eb222060_T001; Zm00001eb222060_P001; Zm00001eb222060.
DR   EnsemblPlants; Zm00001eb222060_T002; Zm00001eb222060_P002; Zm00001eb222060.
DR   GeneID; 541708; -.
DR   Gramene; Zm00001eb222060_T001; Zm00001eb222060_P001; Zm00001eb222060.
DR   Gramene; Zm00001eb222060_T002; Zm00001eb222060_P002; Zm00001eb222060.
DR   KEGG; zma:541708; -.
DR   eggNOG; KOG1670; Eukaryota.
DR   HOGENOM; CLU_043552_2_1_1; -.
DR   OMA; EEFWAIV; -.
DR   OrthoDB; 1394271at2759; -.
DR   Proteomes; UP000007305; Chromosome 5.
DR   ExpressionAtlas; O81482; baseline and differential.
DR   Genevisible; O81482; ZM.
DR   GO; GO:0016281; C:eukaryotic translation initiation factor 4F complex; IBA:GO_Central.
DR   GO; GO:0000340; F:RNA 7-methylguanosine cap binding; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR   Gene3D; 3.30.760.10; -; 1.
DR   InterPro; IPR023398; TIF_eIF4e-like.
DR   InterPro; IPR001040; TIF_eIF_4E.
DR   InterPro; IPR019770; TIF_eIF_4E_CS.
DR   PANTHER; PTHR11960; PTHR11960; 1.
DR   Pfam; PF01652; IF4E; 1.
DR   SUPFAM; SSF55418; SSF55418; 1.
DR   PROSITE; PS00813; IF4E; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Initiation factor; Protein biosynthesis;
KW   Reference proteome; RNA-binding; Translation regulation.
FT   CHAIN           1..216
FT                   /note="Eukaryotic translation initiation factor isoform 4E-
FT                   2"
FT                   /id="PRO_0000193659"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        113..152
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   216 AA;  24104 MW;  20FBAEADB206FAC5 CRC64;
     MAEVEAPATA VEAPAAAVAT TTPEVAAPEA GAATEAKGPH KLHRQWTFWY DIQTKTKSGA
     AWGTSLKKAY TFDTVEEFWS MYDQIFRPSK LSGNADFHLF KAGVEPKWED PECANGGKWT
     VPCNRKATFE TMWLETLMAL IGEQFDETED ICGIVASVRA RGDKLALWTR TASNEAVQVN
     IGKKWKDVID YNDKITYTFH DDSKRDKPSR GGRYTV