IF4E2_ORYSJ
ID IF4E2_ORYSJ Reviewed; 206 AA.
AC P48600; B7F9L1; Q0IX41; Q7XDL0; Q9AV72;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Eukaryotic translation initiation factor isoform 4E-2;
DE Short=eIF(iso)-4E-2;
DE Short=eIF(iso)4E-2;
DE AltName: Full=eIF-(iso)4F 25 kDa subunit;
DE AltName: Full=eIF-(iso)4F p28 subunit;
DE AltName: Full=mRNA cap-binding protein;
GN OrderedLocusNames=Os10g0467600, LOC_Os10g32970;
GN ORFNames=OsJ_31838 {ECO:0000312|EMBL:EEE51107.1}, OSJNBa0006L06.9;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Nipponbare; TISSUE=Root;
RX PubMed=8973371; DOI=10.1016/s0378-1119(96)00418-0;
RA Aliyeva E., Metz A.M., Browning K.S.;
RT "Sequences of two expressed sequence tags (EST) from rice encoding
RT different cap-binding proteins.";
RL Gene 180:221-223(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12791992; DOI=10.1126/science.1083523;
RA Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S.,
RA Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D.,
RA Oates R., Palmer M., Pries G., Gibson J., Anderson H., Paradkar M.,
RA Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F.,
RA Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M.,
RA Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R.,
RA Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F.,
RA Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D.,
RA Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R.,
RA Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K.,
RA Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S.,
RA Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S.,
RA Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R.,
RA Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M.,
RA Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R.,
RA Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E.,
RA Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A.;
RT "In-depth view of structure, activity, and evolution of rice chromosome
RT 10.";
RL Science 300:1566-1569(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RG The rice full-length cDNA consortium;
RT "Oryza sativa full length cDNA.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP GENE FAMILY.
RX PubMed=17898986; DOI=10.1007/s00122-007-0646-6;
RA Boisnard A., Albar L., Thiemele D., Rondeau M., Ghesquiere A.;
RT "Evaluation of genes from eIF4E and eIF4G multigenic families as potential
RT candidates for partial resistance QTLs to Rice yellow mottle virus in
RT rice.";
RL Theor. Appl. Genet. 116:53-62(2007).
CC -!- FUNCTION: Recognizes and binds the 7-methylguanosine-containing mRNA
CC cap during an early step in the initiation of protein synthesis and
CC facilitates ribosome binding by inducing the unwinding of the mRNAs
CC secondary structures.
CC -!- SUBUNIT: EIF4F is a multi-subunit complex, the composition of which
CC varies with external and internal environmental conditions. It is
CC composed of at least EIF4A, EIF4E and EIF4G. EIF4E is also known to
CC interact with other partners. In higher plants two isoforms of EIF4F
CC have been identified, named isoform EIF4F and isoform EIF(iso)4F.
CC Isoform EIF4F has subunits p220 and p26, whereas isoform EIF(iso)4F has
CC subunits p82 and p28.
CC -!- PTM: According to the redox status, the Cys-103-Cys-142 disulfide
CC bridge may have a role in regulating protein function by affecting its
CC ability to bind capped mRNA. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4E family.
CC {ECO:0000305}.
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DR EMBL; U34598; AAB40349.1; -; mRNA.
DR EMBL; AC022457; AAK27811.1; -; Genomic_DNA.
DR EMBL; DP000086; AAP54201.1; -; Genomic_DNA.
DR EMBL; AP008216; BAF26724.1; -; Genomic_DNA.
DR EMBL; AP014966; BAT11224.1; -; Genomic_DNA.
DR EMBL; CM000147; EEE51107.1; -; Genomic_DNA.
DR EMBL; AK242605; BAH01309.1; -; mRNA.
DR PIR; JC5331; JC5331.
DR RefSeq; XP_015615056.1; XM_015759570.1.
DR AlphaFoldDB; P48600; -.
DR SMR; P48600; -.
DR STRING; 4530.OS10T0467600-01; -.
DR PaxDb; P48600; -.
DR PRIDE; P48600; -.
DR EnsemblPlants; Os10t0467600-01; Os10t0467600-01; Os10g0467600.
DR GeneID; 4348852; -.
DR Gramene; Os10t0467600-01; Os10t0467600-01; Os10g0467600.
DR KEGG; osa:4348852; -.
DR eggNOG; KOG1670; Eukaryota.
DR HOGENOM; CLU_043552_2_1_1; -.
DR InParanoid; P48600; -.
DR OMA; EEFWAIV; -.
DR OrthoDB; 1394271at2759; -.
DR Proteomes; UP000000763; Chromosome 10.
DR Proteomes; UP000007752; Chromosome 10.
DR Proteomes; UP000059680; Chromosome 10.
DR Genevisible; P48600; OS.
DR GO; GO:0016281; C:eukaryotic translation initiation factor 4F complex; IBA:GO_Central.
DR GO; GO:0000340; F:RNA 7-methylguanosine cap binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0050687; P:negative regulation of defense response to virus; IEA:EnsemblPlants.
DR GO; GO:0009615; P:response to virus; IEA:EnsemblPlants.
DR Gene3D; 3.30.760.10; -; 1.
DR InterPro; IPR023398; TIF_eIF4e-like.
DR InterPro; IPR001040; TIF_eIF_4E.
DR InterPro; IPR019770; TIF_eIF_4E_CS.
DR PANTHER; PTHR11960; PTHR11960; 1.
DR Pfam; PF01652; IF4E; 1.
DR SUPFAM; SSF55418; SSF55418; 1.
DR PROSITE; PS00813; IF4E; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Initiation factor; Protein biosynthesis;
KW Reference proteome; RNA-binding; Translation regulation.
FT CHAIN 1..206
FT /note="Eukaryotic translation initiation factor isoform 4E-
FT 2"
FT /id="PRO_0000193661"
FT DISULFID 103..142
FT /evidence="ECO:0000250"
FT CONFLICT 92
FT /note="A -> V (in Ref. 1; AAB40349)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 206 AA; 23199 MW; BE1B11793F4A16FB CRC64;
MAEVEAAPIA AAETPEVAAA EGAAAAKAPH KLHRQWAFWY DIQSKPKPGA AWGTSLRKAY
TFDTVEEFWG LYDQIFRPSK VTVNADFHLF KAGVEPKWED PECANGGKWT VPCSRKTTLE
NMWLETLMAL IGEQFDESEE ICGVVASVRQ RGDKLALWTR TASNEAVQVN IGKKWKEIVD
YNDKMVYSFH DDAKREKPSR GGRYNV
