IF4E2_SCHPO
ID IF4E2_SCHPO Reviewed; 243 AA.
AC O74743; Q9UUB9;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 140.
DE RecName: Full=Eukaryotic translation initiation factor 4E-2;
DE Short=eIF-4E-2;
DE Short=eIF4E-2;
DE AltName: Full=eIF-4F 25 kDa subunit 2;
DE AltName: Full=mRNA cap-binding protein 2;
GN Name=tif452; ORFNames=SPBC1709.18, SPBC409.01;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Recognizes and binds the 7-methylguanosine-containing mRNA
CC cap during an early step in the initiation of protein synthesis and
CC facilitates ribosome binding by inducing the unwinding of the mRNAs
CC secondary structures. {ECO:0000250}.
CC -!- SUBUNIT: eIF4F is a multi-subunit complex, the composition of which
CC varies with external and internal environmental conditions. It is
CC composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to
CC interact with other partners (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4E family.
CC {ECO:0000305}.
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DR EMBL; CU329671; CAA21257.1; -; Genomic_DNA.
DR PIR; T39646; T39646.
DR RefSeq; NP_595451.1; NM_001021360.2.
DR AlphaFoldDB; O74743; -.
DR SMR; O74743; -.
DR BioGRID; 276416; 30.
DR STRING; 4896.SPBC1709.18.1; -.
DR iPTMnet; O74743; -.
DR MaxQB; O74743; -.
DR PaxDb; O74743; -.
DR EnsemblFungi; SPBC1709.18.1; SPBC1709.18.1:pep; SPBC1709.18.
DR GeneID; 2539870; -.
DR KEGG; spo:SPBC1709.18; -.
DR PomBase; SPBC1709.18; tif452.
DR VEuPathDB; FungiDB:SPBC1709.18; -.
DR eggNOG; KOG1670; Eukaryota.
DR HOGENOM; CLU_043552_2_2_1; -.
DR InParanoid; O74743; -.
DR OMA; VKPRICL; -.
DR PhylomeDB; O74743; -.
DR Reactome; R-SPO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-SPO-159227; Transport of the SLBP independent Mature mRNA.
DR Reactome; R-SPO-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR Reactome; R-SPO-72649; Translation initiation complex formation.
DR Reactome; R-SPO-72662; Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S.
DR Reactome; R-SPO-72702; Ribosomal scanning and start codon recognition.
DR PRO; PR:O74743; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0016281; C:eukaryotic translation initiation factor 4F complex; IBA:GO_Central.
DR GO; GO:0000340; F:RNA 7-methylguanosine cap binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; ISO:PomBase.
DR GO; GO:0002183; P:cytoplasmic translational initiation; ISO:PomBase.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISO:PomBase.
DR Gene3D; 3.30.760.10; -; 1.
DR InterPro; IPR023398; TIF_eIF4e-like.
DR InterPro; IPR001040; TIF_eIF_4E.
DR InterPro; IPR019770; TIF_eIF_4E_CS.
DR PANTHER; PTHR11960; PTHR11960; 1.
DR Pfam; PF01652; IF4E; 1.
DR SUPFAM; SSF55418; SSF55418; 1.
DR PROSITE; PS00813; IF4E; 1.
PE 3: Inferred from homology;
KW Initiation factor; Protein biosynthesis; Reference proteome; RNA-binding;
KW Translation regulation.
FT CHAIN 1..243
FT /note="Eukaryotic translation initiation factor 4E-2"
FT /id="PRO_0000193652"
SQ SEQUENCE 243 AA; 27654 MW; 3CAD4E82E07D1B13 CRC64;
MADAEDSRHS KNEGFPNTSL ITEKLDLLDL FGSPKVKTER EGRPARLLEG LSAVNAETAF
VKTHPLQHEW TLWFLKPPTQ GLEWSDLLKE IISFKTVEEF WGIFKTISKA SMLPAKSDYS
YFLKGIRPEW EDPQNMNGGK WAYQSKHKGS NLDELWLYMV LAAIGETLDP TGKEVTGVVC
NMRKGFYRIA VWTRNCNDKD VLEKIGLRFK EVLGISDKET IEYSAHEDSS KAGSMRAKTR
MSL
