ID   IF4E3_DANRE             Reviewed;         224 AA.
AC   Q66HY7; Q4V9B4;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Eukaryotic translation initiation factor 4E type 3;
DE            Short=eIF-4E type 3;
DE            Short=eIF-4E3;
DE            Short=eIF4E type 3;
DE            Short=eIF4E-3;
GN   Name=eif4e3; ORFNames=zgc:92189;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Recognizes and binds the 7-methylguanosine-containing mRNA
CC       cap during an early step in the initiation of protein synthesis.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: eIF4F is a multi-subunit complex, the composition of which
CC       varies with external and internal environmental conditions. It is
CC       composed of at least eIF4A, eIF4E and eIF4G (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4E family.
CC       {ECO:0000305}.
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DR   EMBL; BC081620; AAH81620.1; -; mRNA.
DR   EMBL; BC096972; AAH96972.1; -; mRNA.
DR   RefSeq; NP_001004589.1; NM_001004589.1.
DR   AlphaFoldDB; Q66HY7; -.
DR   SMR; Q66HY7; -.
DR   STRING; 7955.ENSDARP00000015325; -.
DR   PaxDb; Q66HY7; -.
DR   Ensembl; ENSDART00000013768; ENSDARP00000015325; ENSDARG00000005078.
DR   GeneID; 447850; -.
DR   KEGG; dre:447850; -.
DR   CTD; 317649; -.
DR   ZFIN; ZDB-GENE-040912-156; eif4e3.
DR   eggNOG; ENOG502QPP4; Eukaryota.
DR   GeneTree; ENSGT00940000155865; -.
DR   HOGENOM; CLU_043552_5_1_1; -.
DR   InParanoid; Q66HY7; -.
DR   OMA; FQVWNGN; -.
DR   OrthoDB; 1394271at2759; -.
DR   PhylomeDB; Q66HY7; -.
DR   Reactome; R-DRE-1169408; ISG15 antiviral mechanism.
DR   PRO; PR:Q66HY7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 23.
DR   Bgee; ENSDARG00000005078; Expressed in mature ovarian follicle and 28 other tissues.
DR   ExpressionAtlas; Q66HY7; baseline and differential.
DR   GO; GO:0016281; C:eukaryotic translation initiation factor 4F complex; IBA:GO_Central.
DR   GO; GO:0005845; C:mRNA cap binding complex; ISS:UniProtKB.
DR   GO; GO:0000340; F:RNA 7-methylguanosine cap binding; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   Gene3D; 3.30.760.10; -; 1.
DR   InterPro; IPR023398; TIF_eIF4e-like.
DR   InterPro; IPR001040; TIF_eIF_4E.
DR   PANTHER; PTHR11960; PTHR11960; 1.
DR   Pfam; PF01652; IF4E; 1.
DR   SUPFAM; SSF55418; SSF55418; 1.
PE   2: Evidence at transcript level;
KW   Initiation factor; Protein biosynthesis; Reference proteome; RNA-binding;
KW   Translation regulation.
FT   CHAIN           1..224
FT                   /note="Eukaryotic translation initiation factor 4E type 3"
FT                   /id="PRO_0000287699"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         115..116
FT                   /ligand="mRNA"
FT                   /ligand_id="ChEBI:CHEBI:33699"
FT                   /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT                   /ligand_part_id="ChEBI:CHEBI:74429"
FT                   /ligand_part_note="m7GTP residue in mRNA cap"
FT                   /evidence="ECO:0000250"
FT   BINDING         169..174
FT                   /ligand="mRNA"
FT                   /ligand_id="ChEBI:CHEBI:33699"
FT                   /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT                   /ligand_part_id="ChEBI:CHEBI:74429"
FT                   /ligand_part_note="m7GTP residue in mRNA cap"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        130
FT                   /note="V -> E (in Ref. 1; AAH96972)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        219
FT                   /note="G -> S (in Ref. 1; AAH96972)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   224 AA;  25403 MW;  44DC0C3C4B027F2B CRC64;
     MAVPAAPNLQ LNTARQSSPV NSTENDIHID ERELENITNH VEDGTSLPLH SPWTFWLDRS
     LPGTTAAECE SNLKKIYTVH TVQSFWSVYN NIPPVSCLPL RCSYHLMRGE RRPLWEEESN
     AKGGVWKMKV PKESTLAVWK ELLLATIGEQ FTDYCASEDE VVGVSVSVRE REDVVQVWNG
     NASFANEANV LGRIYELLPQ ISFKAVFYKP HEEHHAFEGG RSRH