IF4E3_HUMAN
ID IF4E3_HUMAN Reviewed; 224 AA.
AC Q8N5X7; B2R963; Q6NUT1;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 4.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Eukaryotic translation initiation factor 4E type 3;
DE Short=eIF-4E type 3;
DE Short=eIF-4E3;
DE Short=eIF4E type 3;
DE Short=eIF4E-3;
GN Name=EIF4E3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain, and Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 60-224 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Recognizes and binds the 7-methylguanosine-containing mRNA
CC cap during an early step in the initiation of protein synthesis. May
CC act as an inhibitor of EIF4E1 activity (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: eIF4F is a multi-subunit complex, the composition of which
CC varies with external and internal environmental conditions. It is
CC composed of at least eIF4A, eIF4E and eIF4G (By similarity). EIF4E3
CC interacts with EIF4G1, but not with EIF4EBP1, EIF4EBP2 and EIF4EBP3 (By
CC similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q8N5X7-2; Q16613: AANAT; NbExp=3; IntAct=EBI-17933598, EBI-7451846;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N5X7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N5X7-2; Sequence=VSP_025602;
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4E family.
CC {ECO:0000305}.
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DR EMBL; AK126999; BAG54418.1; -; mRNA.
DR EMBL; AK313656; BAG36410.1; -; mRNA.
DR EMBL; AC134770; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC031289; AAH31289.3; -; mRNA.
DR EMBL; BC068443; AAH68443.1; -; mRNA.
DR CCDS; CCDS33786.1; -. [Q8N5X7-2]
DR CCDS; CCDS46867.1; -. [Q8N5X7-1]
DR RefSeq; NP_001128121.1; NM_001134649.2. [Q8N5X7-2]
DR RefSeq; NP_001128122.1; NM_001134650.1. [Q8N5X7-2]
DR RefSeq; NP_001128123.1; NM_001134651.1. [Q8N5X7-1]
DR RefSeq; NP_001269815.1; NM_001282886.1. [Q8N5X7-2]
DR RefSeq; NP_775495.1; NM_173359.4. [Q8N5X7-2]
DR RefSeq; XP_016861767.1; XM_017006278.1.
DR RefSeq; XP_016861768.1; XM_017006279.1.
DR RefSeq; XP_016861769.1; XM_017006280.1.
DR RefSeq; XP_016861770.1; XM_017006281.1.
DR RefSeq; XP_016861771.1; XM_017006282.1. [Q8N5X7-2]
DR AlphaFoldDB; Q8N5X7; -.
DR SMR; Q8N5X7; -.
DR BioGRID; 130428; 8.
DR IntAct; Q8N5X7; 6.
DR STRING; 9606.ENSP00000393324; -.
DR iPTMnet; Q8N5X7; -.
DR PhosphoSitePlus; Q8N5X7; -.
DR BioMuta; EIF4E3; -.
DR DMDM; 156633293; -.
DR EPD; Q8N5X7; -.
DR jPOST; Q8N5X7; -.
DR MassIVE; Q8N5X7; -.
DR MaxQB; Q8N5X7; -.
DR PaxDb; Q8N5X7; -.
DR PeptideAtlas; Q8N5X7; -.
DR PRIDE; Q8N5X7; -.
DR ProteomicsDB; 72106; -. [Q8N5X7-1]
DR ProteomicsDB; 72107; -. [Q8N5X7-2]
DR ABCD; Q8N5X7; 5 sequenced antibodies.
DR Antibodypedia; 31921; 109 antibodies from 25 providers.
DR DNASU; 317649; -.
DR Ensembl; ENST00000295612.7; ENSP00000295612.3; ENSG00000163412.13. [Q8N5X7-2]
DR Ensembl; ENST00000389826.7; ENSP00000374476.3; ENSG00000163412.13. [Q8N5X7-2]
DR Ensembl; ENST00000421769.6; ENSP00000411762.2; ENSG00000163412.13. [Q8N5X7-2]
DR Ensembl; ENST00000425534.8; ENSP00000393324.2; ENSG00000163412.13. [Q8N5X7-1]
DR Ensembl; ENST00000448225.5; ENSP00000410350.1; ENSG00000163412.13. [Q8N5X7-2]
DR GeneID; 317649; -.
DR KEGG; hsa:317649; -.
DR MANE-Select; ENST00000425534.8; ENSP00000393324.2; NM_001134651.2; NP_001128123.1.
DR UCSC; uc003dov.5; human. [Q8N5X7-1]
DR CTD; 317649; -.
DR DisGeNET; 317649; -.
DR GeneCards; EIF4E3; -.
DR HGNC; HGNC:31837; EIF4E3.
DR HPA; ENSG00000163412; Low tissue specificity.
DR MIM; 609896; gene.
DR neXtProt; NX_Q8N5X7; -.
DR OpenTargets; ENSG00000163412; -.
DR PharmGKB; PA134961880; -.
DR VEuPathDB; HostDB:ENSG00000163412; -.
DR eggNOG; ENOG502QPP4; Eukaryota.
DR GeneTree; ENSGT00940000155865; -.
DR HOGENOM; CLU_043552_5_1_1; -.
DR InParanoid; Q8N5X7; -.
DR OMA; SYFYKRH; -.
DR OrthoDB; 1394271at2759; -.
DR PhylomeDB; Q8N5X7; -.
DR PathwayCommons; Q8N5X7; -.
DR Reactome; R-HSA-1169408; ISG15 antiviral mechanism.
DR SignaLink; Q8N5X7; -.
DR BioGRID-ORCS; 317649; 15 hits in 1068 CRISPR screens.
DR ChiTaRS; EIF4E3; human.
DR GeneWiki; EIF4E3; -.
DR GenomeRNAi; 317649; -.
DR Pharos; Q8N5X7; Tbio.
DR PRO; PR:Q8N5X7; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8N5X7; protein.
DR Bgee; ENSG00000163412; Expressed in buccal mucosa cell and 187 other tissues.
DR ExpressionAtlas; Q8N5X7; baseline and differential.
DR Genevisible; Q8N5X7; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0016281; C:eukaryotic translation initiation factor 4F complex; IBA:GO_Central.
DR GO; GO:0005845; C:mRNA cap binding complex; ISS:UniProtKB.
DR GO; GO:0000340; F:RNA 7-methylguanosine cap binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR Gene3D; 3.30.760.10; -; 1.
DR InterPro; IPR023398; TIF_eIF4e-like.
DR InterPro; IPR001040; TIF_eIF_4E.
DR PANTHER; PTHR11960; PTHR11960; 1.
DR Pfam; PF01652; IF4E; 1.
DR SUPFAM; SSF55418; SSF55418; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Initiation factor; Protein biosynthesis;
KW Reference proteome; RNA-binding; Translation regulation.
FT CHAIN 1..224
FT /note="Eukaryotic translation initiation factor 4E type 3"
FT /id="PRO_0000287697"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 115..116
FT /ligand="mRNA"
FT /ligand_id="ChEBI:CHEBI:33699"
FT /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT /ligand_part_id="ChEBI:CHEBI:74429"
FT /ligand_part_note="m7GTP residue in mRNA cap"
FT /evidence="ECO:0000250"
FT BINDING 169..174
FT /ligand="mRNA"
FT /ligand_id="ChEBI:CHEBI:33699"
FT /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT /ligand_part_id="ChEBI:CHEBI:74429"
FT /ligand_part_note="m7GTP residue in mRNA cap"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..106
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_025602"
SQ SEQUENCE 224 AA; 24441 MW; C724BF3A6438D728 CRC64;
MALPPAAAPP AGAREPPGSR AAAAAAAPEP PLGLQQLSAL QPEPGGVPLH SSWTFWLDRS
LPGATAAECA SNLKKIYTVQ TVQIFWSVYN NIPPVTSLPL RCSYHLMRGE RRPLWEEESN
AKGGVWKMKV PKDSTSTVWK ELLLATIGEQ FTDCAAADDE VIGVSVSVRD REDVVQVWNV
NASLVGEATV LEKIYELLPH ITFKAVFYKP HEEHHAFEGG RGKH
