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IF4E3_WHEAT
ID   IF4E3_WHEAT             Reviewed;         232 AA.
AC   A3RCV9;
DT   09-JAN-2013, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Eukaryotic translation initiation factor NCBP;
DE   AltName: Full=Novel cap-binding protein;
DE            Short=nCBP;
DE   AltName: Full=mRNA cap-binding protein;
GN   Name=NCBP;
OS   Triticum aestivum (Wheat).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Chinese Spring;
RX   PubMed=17913646; DOI=10.1016/s0076-6879(07)30015-3;
RA   Mayberry L.K., Dennis M.D., Leah Allen M., Ruud Nitka K., Murphy P.A.,
RA   Campbell L., Browning K.S.;
RT   "Expression and purification of recombinant wheat translation initiation
RT   factors eIF1, eIF1A, eIF4A, eIF4B, eIF4F, eIF(iso)4F, and eIF5.";
RL   Methods Enzymol. 430:397-408(2007).
CC   -!- FUNCTION: Recognizes and binds the 7-methylguanosine-containing mRNA
CC       cap during an early step in the initiation of protein synthesis and
CC       facilitates ribosome binding by inducing the unwinding of the mRNAs
CC       secondary structures. {ECO:0000250}.
CC   -!- SUBUNIT: EIF4F is a multi-subunit complex, the composition of which
CC       varies with external and internal environmental conditions. It is
CC       composed of at least EIF4A, EIF4E and EIF4G. EIF4E is also known to
CC       interact with other partners. In higher plants two isoforms of EIF4F
CC       have been identified, named isoform EIF4F and isoform EIF(iso)4F.
CC       Isoform EIF4F has subunits p220 and p26, whereas isoform EIF(iso)4F has
CC       subunits p82 and p28 (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4E family.
CC       {ECO:0000305}.
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DR   EMBL; EF190327; ABO15890.1; -; mRNA.
DR   AlphaFoldDB; A3RCV9; -.
DR   SMR; A3RCV9; -.
DR   STRING; 4565.Traes_4BL_96D26EBE3.2; -.
DR   EnsemblPlants; TraesCAD_scaffold_029241_01G000100.1; TraesCAD_scaffold_029241_01G000100.1; TraesCAD_scaffold_029241_01G000100.
DR   EnsemblPlants; TraesCLE_scaffold_039793_01G000100.1; TraesCLE_scaffold_039793_01G000100.1; TraesCLE_scaffold_039793_01G000100.
DR   EnsemblPlants; TraesCS4D02G216800.1; TraesCS4D02G216800.1; TraesCS4D02G216800.
DR   EnsemblPlants; TraesPAR_scaffold_039972_01G000100.1; TraesPAR_scaffold_039972_01G000100.1; TraesPAR_scaffold_039972_01G000100.
DR   EnsemblPlants; TraesROB_scaffold_015865_01G000200.1; TraesROB_scaffold_015865_01G000200.1; TraesROB_scaffold_015865_01G000200.
DR   EnsemblPlants; TraesWEE_scaffold_035966_01G000100.1; TraesWEE_scaffold_035966_01G000100.1; TraesWEE_scaffold_035966_01G000100.
DR   Gramene; TraesCAD_scaffold_029241_01G000100.1; TraesCAD_scaffold_029241_01G000100.1; TraesCAD_scaffold_029241_01G000100.
DR   Gramene; TraesCLE_scaffold_039793_01G000100.1; TraesCLE_scaffold_039793_01G000100.1; TraesCLE_scaffold_039793_01G000100.
DR   Gramene; TraesCS4D02G216800.1; TraesCS4D02G216800.1; TraesCS4D02G216800.
DR   Gramene; TraesPAR_scaffold_039972_01G000100.1; TraesPAR_scaffold_039972_01G000100.1; TraesPAR_scaffold_039972_01G000100.
DR   Gramene; TraesROB_scaffold_015865_01G000200.1; TraesROB_scaffold_015865_01G000200.1; TraesROB_scaffold_015865_01G000200.
DR   Gramene; TraesWEE_scaffold_035966_01G000100.1; TraesWEE_scaffold_035966_01G000100.1; TraesWEE_scaffold_035966_01G000100.
DR   eggNOG; KOG1669; Eukaryota.
DR   OMA; ANCHGGK; -.
DR   Proteomes; UP000019116; Unplaced.
DR   GO; GO:0016281; C:eukaryotic translation initiation factor 4F complex; IBA:GO_Central.
DR   GO; GO:0000340; F:RNA 7-methylguanosine cap binding; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR   Gene3D; 3.30.760.10; -; 1.
DR   InterPro; IPR023398; TIF_eIF4e-like.
DR   InterPro; IPR001040; TIF_eIF_4E.
DR   InterPro; IPR019770; TIF_eIF_4E_CS.
DR   PANTHER; PTHR11960; PTHR11960; 1.
DR   Pfam; PF01652; IF4E; 1.
DR   SUPFAM; SSF55418; SSF55418; 1.
DR   PROSITE; PS00813; IF4E; 1.
PE   2: Evidence at transcript level;
KW   Initiation factor; Protein biosynthesis; Reference proteome; RNA-binding;
KW   Translation regulation.
FT   CHAIN           1..232
FT                   /note="Eukaryotic translation initiation factor NCBP"
FT                   /id="PRO_0000420541"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   232 AA;  26998 MW;  50E499D173905822 CRC64;
     MEPAVERKVP EQEEQLQPSH ARAEDAPPAA VEEEDEAEAE ESERRNRELK AGLHPLRRKL
     VLWYTRRTPG TRSQSYEDNI KKIVDFSTVE SFWVCYCHLA RPSSLPSPTD LHLFKEGVRP
     LWEDPANRNG GKWIIRFKKA VSGRFWEDLV LVLVGDQLDY SDDVCGIVLS CRFNEDILSV
     WNRNASDHQA VMTLRDSIKR HLKLPHTYLM EYKPHDASLR DNSSYRNTWL RG
 
 
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