ID   IF4E3_XENTR             Reviewed;         218 AA.
AC   Q28ET8;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Eukaryotic translation initiation factor 4E type 3;
DE            Short=eIF-4E type 3;
DE            Short=eIF-4E3;
DE            Short=eIF4E type 3;
DE            Short=eIF4E-3;
GN   Name=eif4e3; ORFNames=TGas108j06.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Recognizes and binds the 7-methylguanosine-containing mRNA
CC       cap during an early step in the initiation of protein synthesis.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: eIF4F is a multi-subunit complex, the composition of which
CC       varies with external and internal environmental conditions. It is
CC       composed of at least eIF4A, eIF4E and eIF4G (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4E family.
CC       {ECO:0000305}.
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DR   EMBL; CR762349; CAJ83493.1; -; mRNA.
DR   RefSeq; NP_001016049.1; NM_001016049.2.
DR   AlphaFoldDB; Q28ET8; -.
DR   SMR; Q28ET8; -.
DR   STRING; 8364.ENSXETP00000010993; -.
DR   PaxDb; Q28ET8; -.
DR   GeneID; 548803; -.
DR   KEGG; xtr:548803; -.
DR   CTD; 317649; -.
DR   Xenbase; XB-GENE-992071; eif4e3.
DR   eggNOG; ENOG502QPP4; Eukaryota.
DR   HOGENOM; CLU_043552_5_1_1; -.
DR   InParanoid; Q28ET8; -.
DR   OrthoDB; 1394271at2759; -.
DR   Reactome; R-XTR-1169408; ISG15 antiviral mechanism.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016281; C:eukaryotic translation initiation factor 4F complex; IBA:GO_Central.
DR   GO; GO:0005845; C:mRNA cap binding complex; ISS:UniProtKB.
DR   GO; GO:0000340; F:RNA 7-methylguanosine cap binding; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   Gene3D; 3.30.760.10; -; 1.
DR   InterPro; IPR023398; TIF_eIF4e-like.
DR   InterPro; IPR001040; TIF_eIF_4E.
DR   PANTHER; PTHR11960; PTHR11960; 1.
DR   Pfam; PF01652; IF4E; 1.
DR   SUPFAM; SSF55418; SSF55418; 1.
PE   2: Evidence at transcript level;
KW   Initiation factor; Protein biosynthesis; Reference proteome; RNA-binding;
KW   Translation regulation.
FT   CHAIN           1..218
FT                   /note="Eukaryotic translation initiation factor 4E type 3"
FT                   /id="PRO_0000287702"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         109..110
FT                   /ligand="mRNA"
FT                   /ligand_id="ChEBI:CHEBI:33699"
FT                   /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT                   /ligand_part_id="ChEBI:CHEBI:74429"
FT                   /ligand_part_note="m7GTP residue in mRNA cap"
FT                   /evidence="ECO:0000250"
FT   BINDING         163..168
FT                   /ligand="mRNA"
FT                   /ligand_id="ChEBI:CHEBI:33699"
FT                   /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT                   /ligand_part_id="ChEBI:CHEBI:74429"
FT                   /ligand_part_note="m7GTP residue in mRNA cap"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   218 AA;  24871 MW;  95BA4D34FD600E47 CRC64;
     MALPAAPADR RLQPEPDEQL HLNHRELGEL ALPQEPDTEG IPLHSPWTFW LDRSLPGTTA
     AECESNLKKI YTVHTIQSFW SVYNNIPQVT NLPLRWSYHL MRGERKPLWE EESNAKGGVW
     KMKVPKEASS LVWKELLLAT IGEQFTDRCA PEDEVIGVSV SVRDREDVVQ VWNGNASVVG
     EATVLEKIYE LLPNTSFKAV FYKPHEEHHA FEGGRSRH