IF4EA_DANRE
ID IF4EA_DANRE Reviewed; 215 AA.
AC Q9DFS6;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Eukaryotic translation initiation factor 4E-1A;
DE Short=eIF4E-1A;
DE AltName: Full=mRNA cap-binding protein;
GN Name=eif4e1a {ECO:0000312|ZFIN:ZDB-GENE-040413-1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAG09794.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH EIF4EBP3L,
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=14701818; DOI=10.1074/jbc.m313688200;
RA Robalino J., Joshi B., Fahrenkrug S.C., Jagus R.;
RT "Two zebrafish eIF4E family members are differentially expressed and
RT functionally divergent.";
RL J. Biol. Chem. 279:10532-10541(2004).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAH71364.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000312|EMBL:AAH71364.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Recognizes and binds the 7-methylguanosine-containing mRNA
CC cap during an early step in the initiation of protein synthesis and
CC facilitates ribosome binding by inducing the unwinding of the mRNAs
CC secondary structures. {ECO:0000269|PubMed:14701818}.
CC -!- SUBUNIT: Interacts with eif4ebp3l. {ECO:0000269|PubMed:14701818}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14701818}. Nucleus
CC {ECO:0000269|PubMed:14701818}.
CC -!- TISSUE SPECIFICITY: Expressed in all tissues examined, including gill,
CC fin, heart, intestine, muscle, ovary and testis.
CC {ECO:0000269|PubMed:14701818}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. Zygotic
CC expression persists into the pharyngula stage.
CC {ECO:0000269|PubMed:14701818}.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4E family.
CC {ECO:0000255}.
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DR EMBL; AF257519; AAG09794.1; -; mRNA.
DR EMBL; BC071364; AAH71364.1; -; mRNA.
DR RefSeq; NP_571808.1; NM_131733.1.
DR AlphaFoldDB; Q9DFS6; -.
DR SMR; Q9DFS6; -.
DR STRING; 7955.ENSDARP00000103599; -.
DR PaxDb; Q9DFS6; -.
DR Ensembl; ENSDART00000183348; ENSDARP00000156965; ENSDARG00000115520.
DR GeneID; 79380; -.
DR KEGG; dre:79380; -.
DR CTD; 79380; -.
DR ZFIN; ZDB-GENE-040413-1; eif4ea.
DR eggNOG; KOG1670; Eukaryota.
DR InParanoid; Q9DFS6; -.
DR OrthoDB; 1394271at2759; -.
DR PhylomeDB; Q9DFS6; -.
DR PRO; PR:Q9DFS6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0016281; C:eukaryotic translation initiation factor 4F complex; ISS:UniProtKB.
DR GO; GO:0005845; C:mRNA cap binding complex; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0000340; F:RNA 7-methylguanosine cap binding; IDA:UniProtKB.
DR GO; GO:0003743; F:translation initiation factor activity; IDA:ZFIN.
DR GO; GO:0006417; P:regulation of translation; ISS:UniProtKB.
DR GO; GO:0006413; P:translational initiation; IDA:ZFIN.
DR Gene3D; 3.30.760.10; -; 1.
DR InterPro; IPR023398; TIF_eIF4e-like.
DR InterPro; IPR001040; TIF_eIF_4E.
DR InterPro; IPR019770; TIF_eIF_4E_CS.
DR PANTHER; PTHR11960; PTHR11960; 1.
DR Pfam; PF01652; IF4E; 1.
DR SUPFAM; SSF55418; SSF55418; 1.
DR PROSITE; PS00813; IF4E; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Initiation factor; Nucleus; Protein biosynthesis;
KW Reference proteome; RNA-binding; Translation regulation.
FT CHAIN 1..215
FT /note="Eukaryotic translation initiation factor 4E-1A"
FT /id="PRO_0000193638"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 54..55
FT /ligand="mRNA"
FT /ligand_id="ChEBI:CHEBI:33699"
FT /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT /ligand_part_id="ChEBI:CHEBI:74429"
FT /ligand_part_note="m7GTP residue in mRNA cap"
FT /evidence="ECO:0000250"
FT BINDING 100..101
FT /ligand="mRNA"
FT /ligand_id="ChEBI:CHEBI:33699"
FT /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT /ligand_part_id="ChEBI:CHEBI:74429"
FT /ligand_part_note="m7GTP residue in mRNA cap"
FT /evidence="ECO:0000250"
FT BINDING 155..160
FT /ligand="mRNA"
FT /ligand_id="ChEBI:CHEBI:33699"
FT /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT /ligand_part_id="ChEBI:CHEBI:74429"
FT /ligand_part_note="m7GTP residue in mRNA cap"
FT /evidence="ECO:0000250"
FT BINDING 203..205
FT /ligand="mRNA"
FT /ligand_id="ChEBI:CHEBI:33699"
FT /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT /ligand_part_id="ChEBI:CHEBI:74429"
FT /ligand_part_note="m7GTP residue in mRNA cap"
FT /evidence="ECO:0000250"
SQ SEQUENCE 215 AA; 24850 MW; 606C1044C0E7FA58 CRC64;
MATAEPETST NPSNSEEKNE ENEQQIVSLE DYIKHPLQNR WALWFFKNDK SKTWQANLRL
ISKFDTVEDF WALYNHIQLS SNLMSGCDYS LFKDGIEPMW EDERNKRGGR WLITLSKQQR
RADLDRFWLE TLLCLVGEAF DDHSDDVCGA VVNIRTKGDK IAIWTTDYEN KDAIVHIGRV
YKERLGVPPK VIIGYQSHAD TATKSGSTTK NKFVV
