IF4EB_DANRE
ID IF4EB_DANRE Reviewed; 214 AA.
AC Q9PW28; Q9PW27;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Eukaryotic translation initiation factor 4E-1B;
DE Short=eIF4E;
DE Short=eIF4E-1B;
GN Name=eif4e1b {ECO:0000312|ZFIN:ZDB-GENE-980526-127};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAD50526.1}
RP NUCLEOTIDE SEQUENCE [MRNA], NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-70, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Oocyte {ECO:0000269|PubMed:10653355};
RX PubMed=10653355; DOI=10.1046/j.1432-0436.1999.6540191.x;
RA Fahrenkrug S.C., Dahlquist M.O., Clark K.J., Hackett P.B.;
RT "Dynamic and tissue-specific expression of eIF4E during zebrafish
RT embryogenesis.";
RL Differentiation 65:191-201(1999).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAH55649.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=14701818; DOI=10.1074/jbc.m313688200;
RA Robalino J., Joshi B., Fahrenkrug S.C., Jagus R.;
RT "Two zebrafish eIF4E family members are differentially expressed and
RT functionally divergent.";
RL J. Biol. Chem. 279:10532-10541(2004).
CC -!- FUNCTION: Does not appear to be a mRNA-cap-binding protein.
CC {ECO:0000303|PubMed:14701818}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14701818}. Nucleus
CC {ECO:0000269|PubMed:14701818}.
CC -!- TISSUE SPECIFICITY: Ovary, muscle and testis.
CC {ECO:0000269|PubMed:14701818}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. Levels
CC decrease on oocyte maturation, increase during the midblastula
CC transition, then decline again and are lost by 24 hours post-
CC fertilization (hpf). Uniform distribution during gastrulation, but
CC later becomes concentrated in mesodermal lineages, particularly those
CC located ventrally. {ECO:0000269|PubMed:10653355,
CC ECO:0000269|PubMed:14701818}.
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DR EMBL; AF176317; AAD50526.1; -; mRNA.
DR EMBL; AF176318; AAD51083.1; -; Genomic_DNA.
DR EMBL; BC055649; AAH55649.1; -; mRNA.
DR RefSeq; NP_571529.1; NM_131454.1.
DR AlphaFoldDB; Q9PW28; -.
DR SMR; Q9PW28; -.
DR STRING; 7955.ENSDARP00000022906; -.
DR PaxDb; Q9PW28; -.
DR Ensembl; ENSDART00000017881; ENSDARP00000022906; ENSDARG00000014565.
DR GeneID; 30738; -.
DR KEGG; dre:30738; -.
DR CTD; 253314; -.
DR ZFIN; ZDB-GENE-980526-127; eif4e1b.
DR eggNOG; KOG1670; Eukaryota.
DR GeneTree; ENSGT00940000160838; -.
DR HOGENOM; CLU_043552_1_0_1; -.
DR InParanoid; Q9PW28; -.
DR OMA; NKFGGRW; -.
DR OrthoDB; 1394271at2759; -.
DR PhylomeDB; Q9PW28; -.
DR TreeFam; TF101526; -.
DR PRO; PR:Q9PW28; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 5.
DR Bgee; ENSDARG00000014565; Expressed in testis and 30 other tissues.
DR ExpressionAtlas; Q9PW28; baseline.
DR GO; GO:0016281; C:eukaryotic translation initiation factor 4F complex; ISS:UniProtKB.
DR GO; GO:0005845; C:mRNA cap binding complex; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; ISS:UniProtKB.
DR GO; GO:0006417; P:regulation of translation; ISS:UniProtKB.
DR Gene3D; 3.30.760.10; -; 1.
DR InterPro; IPR023398; TIF_eIF4e-like.
DR InterPro; IPR001040; TIF_eIF_4E.
DR InterPro; IPR019770; TIF_eIF_4E_CS.
DR PANTHER; PTHR11960; PTHR11960; 1.
DR Pfam; PF01652; IF4E; 1.
DR SUPFAM; SSF55418; SSF55418; 1.
DR PROSITE; PS00813; IF4E; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..214
FT /note="Eukaryotic translation initiation factor 4E-1B"
FT /id="PRO_0000193639"
FT BINDING 53..54
FT /ligand="mRNA"
FT /ligand_id="ChEBI:CHEBI:33699"
FT /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT /ligand_part_id="ChEBI:CHEBI:74429"
FT /ligand_part_note="m7GTP residue in mRNA cap"
FT /evidence="ECO:0000250"
FT BINDING 99..100
FT /ligand="mRNA"
FT /ligand_id="ChEBI:CHEBI:33699"
FT /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT /ligand_part_id="ChEBI:CHEBI:74429"
FT /ligand_part_note="m7GTP residue in mRNA cap"
FT /evidence="ECO:0000250"
FT BINDING 154..159
FT /ligand="mRNA"
FT /ligand_id="ChEBI:CHEBI:33699"
FT /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT /ligand_part_id="ChEBI:CHEBI:74429"
FT /ligand_part_note="m7GTP residue in mRNA cap"
FT /evidence="ECO:0000250"
FT BINDING 202..204
FT /ligand="mRNA"
FT /ligand_id="ChEBI:CHEBI:33699"
FT /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT /ligand_part_id="ChEBI:CHEBI:74429"
FT /ligand_part_note="m7GTP residue in mRNA cap"
FT /evidence="ECO:0000250"
SQ SEQUENCE 214 AA; 24745 MW; D9C1F4D4B5A00DC3 CRC64;
MASCAVQLID KVPKKKVEKK KFEPNILKEP CMKHPLQNRW GLWFYKNDKS KMWQDNLRLI
TKFDTVEDFW GLYNNIQLPS KLSSGCDYSM FKDGIEPMWE DRSNKCGGRW LITLAKQHRH
TELDHFWLET LLCLIGEGFS SFSRDICGSV INIRAKGDKI ALWTSNAENC ETVTYIGRKY
KESLGLPQKL VIGYQAHADT ATKSNSITKN KFVV
