IF4EH_MIMIV
ID IF4EH_MIMIV Reviewed; 272 AA.
AC Q5UQG4;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Eukaryotic translation initiation factor 4E homolog;
DE Short=eIF-4E;
DE Short=eIF4E;
DE AltName: Full=mRNA cap-binding protein;
GN OrderedLocusNames=MIMI_L496;
OS Acanthamoeba polyphaga mimivirus (APMV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC Imitervirales; Mimiviridae; Mimivirus.
OX NCBI_TaxID=212035;
OH NCBI_TaxID=5757; Acanthamoeba polyphaga (Amoeba).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rowbotham-Bradford;
RX PubMed=15486256; DOI=10.1126/science.1101485;
RA Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H.,
RA La Scola B., Susan M., Claverie J.-M.;
RT "The 1.2-megabase genome sequence of Mimivirus.";
RL Science 306:1344-1350(2004).
CC -!- FUNCTION: Recognizes and binds the 7-methylguanosine-containing mRNA
CC cap during an early step in the initiation of protein synthesis and
CC facilitates ribosome binding by inducing the unwinding of the mRNAs
CC secondary structures. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4E family.
CC {ECO:0000305}.
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DR EMBL; AY653733; AAV50761.1; -; Genomic_DNA.
DR RefSeq; YP_003987008.1; NC_014649.1.
DR SMR; Q5UQG4; -.
DR GeneID; 9925126; -.
DR KEGG; vg:9925126; -.
DR Proteomes; UP000001134; Genome.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.760.10; -; 1.
DR InterPro; IPR023398; TIF_eIF4e-like.
DR InterPro; IPR001040; TIF_eIF_4E.
DR PANTHER; PTHR11960; PTHR11960; 1.
DR Pfam; PF01652; IF4E; 1.
DR SUPFAM; SSF55418; SSF55418; 1.
PE 3: Inferred from homology;
KW Initiation factor; Protein biosynthesis; Reference proteome; RNA-binding;
KW Translation regulation.
FT CHAIN 1..272
FT /note="Eukaryotic translation initiation factor 4E homolog"
FT /id="PRO_0000193667"
FT REGION 249..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 272 AA; 30949 MW; D41E255859160777 CRC64;
MDSNNTEFKD NYQHIPDDIP LTNIKLPNEW VLYLYDKQLF KKMANRPNFQ AKPHKALCTI
STVNDLLYIM ELMKVNNDPK IKSVETDGKI NLDANDYIIM RKGIEPIWED PRNSNGGTFT
VKMDHSKGYD VWKIFIQYIL GETLTSEISD MKSINGITVS YISDSYNFQN PASKNTLGNT
LGNSLGNSLG NGLGNSFTYI KIWDGKPDRT RDQFVSMLPA TIIDKIKSDS LMYSQNSKKK
HFNEKNIIGK LNSGRKPSNT RGGFSSFGNK RY