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IF4EH_MIMIV
ID   IF4EH_MIMIV             Reviewed;         272 AA.
AC   Q5UQG4;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Eukaryotic translation initiation factor 4E homolog;
DE            Short=eIF-4E;
DE            Short=eIF4E;
DE   AltName: Full=mRNA cap-binding protein;
GN   OrderedLocusNames=MIMI_L496;
OS   Acanthamoeba polyphaga mimivirus (APMV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Imitervirales; Mimiviridae; Mimivirus.
OX   NCBI_TaxID=212035;
OH   NCBI_TaxID=5757; Acanthamoeba polyphaga (Amoeba).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rowbotham-Bradford;
RX   PubMed=15486256; DOI=10.1126/science.1101485;
RA   Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H.,
RA   La Scola B., Susan M., Claverie J.-M.;
RT   "The 1.2-megabase genome sequence of Mimivirus.";
RL   Science 306:1344-1350(2004).
CC   -!- FUNCTION: Recognizes and binds the 7-methylguanosine-containing mRNA
CC       cap during an early step in the initiation of protein synthesis and
CC       facilitates ribosome binding by inducing the unwinding of the mRNAs
CC       secondary structures. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4E family.
CC       {ECO:0000305}.
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DR   EMBL; AY653733; AAV50761.1; -; Genomic_DNA.
DR   RefSeq; YP_003987008.1; NC_014649.1.
DR   SMR; Q5UQG4; -.
DR   GeneID; 9925126; -.
DR   KEGG; vg:9925126; -.
DR   Proteomes; UP000001134; Genome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.760.10; -; 1.
DR   InterPro; IPR023398; TIF_eIF4e-like.
DR   InterPro; IPR001040; TIF_eIF_4E.
DR   PANTHER; PTHR11960; PTHR11960; 1.
DR   Pfam; PF01652; IF4E; 1.
DR   SUPFAM; SSF55418; SSF55418; 1.
PE   3: Inferred from homology;
KW   Initiation factor; Protein biosynthesis; Reference proteome; RNA-binding;
KW   Translation regulation.
FT   CHAIN           1..272
FT                   /note="Eukaryotic translation initiation factor 4E homolog"
FT                   /id="PRO_0000193667"
FT   REGION          249..272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        252..272
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   272 AA;  30949 MW;  D41E255859160777 CRC64;
     MDSNNTEFKD NYQHIPDDIP LTNIKLPNEW VLYLYDKQLF KKMANRPNFQ AKPHKALCTI
     STVNDLLYIM ELMKVNNDPK IKSVETDGKI NLDANDYIIM RKGIEPIWED PRNSNGGTFT
     VKMDHSKGYD VWKIFIQYIL GETLTSEISD MKSINGITVS YISDSYNFQN PASKNTLGNT
     LGNSLGNSLG NGLGNSFTYI KIWDGKPDRT RDQFVSMLPA TIIDKIKSDS LMYSQNSKKK
     HFNEKNIIGK LNSGRKPSNT RGGFSSFGNK RY
 
 
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