ID   IF4E_APLCA              Reviewed;         215 AA.
AC   O77210;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Eukaryotic translation initiation factor 4E;
DE            Short=eIF-4E;
DE            Short=eIF4E;
DE   AltName: Full=eIF-4F 25 kDa subunit;
DE   AltName: Full=mRNA cap-binding protein;
OS   Aplysia californica (California sea hare).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Tectipleura; Aplysiida; Aplysioidea;
OC   Aplysiidae; Aplysia.
OX   NCBI_TaxID=6500;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PHOSPHORYLATION AT SER-207.
RC   TISSUE=Nerve;
RX   PubMed=9792652; DOI=10.1074/jbc.273.45.29469;
RA   Dyer J.R., Pepio A.M., Yanow S.K., Sossin W.S.;
RT   "Phosphorylation of eIF4E at a conserved serine in Aplysia.";
RL   J. Biol. Chem. 273:29469-29474(1998).
CC   -!- FUNCTION: Recognizes and binds the 7-methylguanosine-containing mRNA
CC       cap during an early step in the initiation of protein synthesis and
CC       facilitates ribosome binding by inducing the unwinding of the mRNAs
CC       secondary structures.
CC   -!- SUBUNIT: eIF4F is a multi-subunit complex, the composition of which
CC       varies with external and internal environmental conditions. It is
CC       composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to
CC       interact with other partners (By similarity). {ECO:0000250}.
CC   -!- PTM: Phosphorylation increases the ability of the protein to bind to
CC       mRNA caps and to form the eIF4F complex. {ECO:0000269|PubMed:9792652}.
CC   -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4E family.
CC       {ECO:0000305}.
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DR   EMBL; AF085810; AAC36720.1; -; mRNA.
DR   RefSeq; NP_001191552.1; NM_001204623.1.
DR   AlphaFoldDB; O77210; -.
DR   SMR; O77210; -.
DR   iPTMnet; O77210; -.
DR   GeneID; 100533326; -.
DR   OrthoDB; 1394271at2759; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.760.10; -; 1.
DR   InterPro; IPR023398; TIF_eIF4e-like.
DR   InterPro; IPR001040; TIF_eIF_4E.
DR   InterPro; IPR019770; TIF_eIF_4E_CS.
DR   PANTHER; PTHR11960; PTHR11960; 1.
DR   Pfam; PF01652; IF4E; 1.
DR   SUPFAM; SSF55418; SSF55418; 1.
DR   PROSITE; PS00813; IF4E; 1.
PE   1: Evidence at protein level;
KW   Initiation factor; Phosphoprotein; Protein biosynthesis; RNA-binding;
KW   Translation regulation.
FT   CHAIN           1..215
FT                   /note="Eukaryotic translation initiation factor 4E"
FT                   /id="PRO_0000193641"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         207
FT                   /note="Phosphoserine; by PKC"
FT                   /evidence="ECO:0000269|PubMed:9792652"
SQ   SEQUENCE   215 AA;  24646 MW;  9EE00CB6DE8162E7 CRC64;
     MAERDSEPRV NIIRPDDEPE VEEERVPDPD MVIKHPLQNS WAMWFFKNDK SRDWKDNLRV
     ITTFDTVEDF WGLYNHTLPA SKLQSGCDYS VFKAGIQPMW EDAQNKKGGR WLINLNKTQR
     QTHLDDFWLE TLLCLIGEGF DEHSEEICGA TVNIRNKGDK LGLWTRDAQK TEATKKIGIK
     LKESLSVPPK IVIGFQAHSD TAGKAGSTVK NRFTV