IF4E_CANAL
ID IF4E_CANAL Reviewed; 209 AA.
AC Q9P975; A0A1D8PU76; Q5ACL6;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Eukaryotic translation initiation factor 4E;
DE Short=eIF-4E;
DE Short=eIF4E;
DE AltName: Full=eIF-4F 25 kDa subunit;
DE AltName: Full=mRNA cap-binding protein;
GN Name=TIF45; Synonyms=EIF4E; OrderedLocusNames=CAALFM_CR10490WA;
GN ORFNames=CaO19.7626;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SC5314 / CAI4 / ATCC MYA-682;
RA Ono N., Sudoh M.;
RT "Candida albicans eIF4E gene.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Recognizes and binds the 7-methylguanosine-containing mRNA
CC cap during an early step in the initiation of protein synthesis and
CC facilitates ribosome binding by inducing the unwinding of the mRNAs
CC secondary structures. {ECO:0000250}.
CC -!- SUBUNIT: eIF4F is a multi-subunit complex, the composition of which
CC varies with external and internal environmental conditions. It is
CC composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to
CC interact with other partners (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4E family.
CC {ECO:0000305}.
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DR EMBL; AB036332; BAA93570.1; -; Genomic_DNA.
DR EMBL; CP017630; AOW31698.1; -; Genomic_DNA.
DR RefSeq; XP_719387.1; XM_714294.1.
DR AlphaFoldDB; Q9P975; -.
DR SMR; Q9P975; -.
DR STRING; 237561.Q9P975; -.
DR PRIDE; Q9P975; -.
DR GeneID; 3638981; -.
DR KEGG; cal:CAALFM_CR10490WA; -.
DR CGD; CAL0000195194; EIF4E.
DR VEuPathDB; FungiDB:CR_10490W_A; -.
DR eggNOG; KOG1670; Eukaryota.
DR HOGENOM; CLU_043552_2_2_1; -.
DR InParanoid; Q9P975; -.
DR OMA; VKPRICL; -.
DR OrthoDB; 1394271at2759; -.
DR Proteomes; UP000000559; Chromosome R.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:EnsemblFungi.
DR GO; GO:0016281; C:eukaryotic translation initiation factor 4F complex; IBA:GO_Central.
DR GO; GO:0005845; C:mRNA cap binding complex; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR GO; GO:0098808; F:mRNA cap binding; IEA:EnsemblFungi.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:EnsemblFungi.
DR GO; GO:0000340; F:RNA 7-methylguanosine cap binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IGI:CGD.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:EnsemblFungi.
DR GO; GO:1901195; P:positive regulation of formation of translation preinitiation complex; IEA:EnsemblFungi.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:EnsemblFungi.
DR GO; GO:0006413; P:translational initiation; IGI:CGD.
DR Gene3D; 3.30.760.10; -; 1.
DR InterPro; IPR023398; TIF_eIF4e-like.
DR InterPro; IPR001040; TIF_eIF_4E.
DR InterPro; IPR019770; TIF_eIF_4E_CS.
DR PANTHER; PTHR11960; PTHR11960; 1.
DR Pfam; PF01652; IF4E; 1.
DR SUPFAM; SSF55418; SSF55418; 1.
DR PROSITE; PS00813; IF4E; 1.
PE 3: Inferred from homology;
KW Initiation factor; Protein biosynthesis; Reference proteome; RNA-binding;
KW Translation regulation.
FT CHAIN 1..209
FT /note="Eukaryotic translation initiation factor 4E"
FT /id="PRO_0000193649"
FT BINDING 51..52
FT /ligand="mRNA"
FT /ligand_id="ChEBI:CHEBI:33699"
FT /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT /ligand_part_id="ChEBI:CHEBI:74429"
FT /ligand_part_note="m7GTP residue in mRNA cap"
FT /evidence="ECO:0000250"
FT BINDING 97..98
FT /ligand="mRNA"
FT /ligand_id="ChEBI:CHEBI:33699"
FT /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT /ligand_part_id="ChEBI:CHEBI:74429"
FT /ligand_part_note="m7GTP residue in mRNA cap"
FT /evidence="ECO:0000250"
FT BINDING 153..158
FT /ligand="mRNA"
FT /ligand_id="ChEBI:CHEBI:33699"
FT /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT /ligand_part_id="ChEBI:CHEBI:74429"
FT /ligand_part_note="m7GTP residue in mRNA cap"
FT /evidence="ECO:0000250"
SQ SEQUENCE 209 AA; 24238 MW; ED8E97FA037D5838 CRC64;
MSEELAQKTE ELSLDSKTVF DSKEEFNAKH PLNSRWTLWY TKPQTNKSEN WHDLLKPVIT
FSSVEEFWGI YNSIPPANQL PLKSDYHLFK EGIRPEWEDE ANSKGGKWQF SFNKKSEVNP
IINDLWLRGL LAVIGETIED EENEVNGIVL NIRKQAYRVG IWTKDCDESK LKTVGERLKK
VLQLNDEQKV EFMSHDASNT RGAEPQIVL
