ID   IF4E_CANGA              Reviewed;         209 AA.
AC   Q9P974; Q6FVJ2;
DT   10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   31-AUG-2004, sequence version 2.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Eukaryotic translation initiation factor 4E;
DE            Short=eIF-4E;
DE            Short=eIF4E;
DE   AltName: Full=eIF-4F 25 kDa subunit;
DE   AltName: Full=mRNA cap-binding protein;
GN   Name=TIF45; OrderedLocusNames=CAGL0E01463g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Ono N., Sudoh M.;
RT   "Candida glabrata eIF4E gene.";
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Recognizes and binds the 7-methylguanosine-containing mRNA
CC       cap during an early step in the initiation of protein synthesis and
CC       facilitates ribosome binding by inducing the unwinding of the mRNAs
CC       secondary structures. {ECO:0000250}.
CC   -!- SUBUNIT: eIF4F is a multi-subunit complex, the composition of which
CC       varies with external and internal environmental conditions. It is
CC       composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to
CC       interact with other partners (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4E family.
CC       {ECO:0000305}.
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DR   EMBL; AB036333; BAA93571.1; -; Genomic_DNA.
DR   EMBL; CR380951; CAG58671.1; -; Genomic_DNA.
DR   RefSeq; XP_445752.1; XM_445752.1.
DR   AlphaFoldDB; Q9P974; -.
DR   SMR; Q9P974; -.
DR   STRING; 5478.XP_445752.1; -.
DR   EnsemblFungi; CAG58671; CAG58671; CAGL0E01463g.
DR   GeneID; 2887437; -.
DR   KEGG; cgr:CAGL0E01463g; -.
DR   CGD; CAL0128640; CDC33.
DR   VEuPathDB; FungiDB:CAGL0E01463g; -.
DR   eggNOG; KOG1670; Eukaryota.
DR   HOGENOM; CLU_043552_2_2_1; -.
DR   InParanoid; Q9P974; -.
DR   OMA; EEFWAIV; -.
DR   Proteomes; UP000002428; Chromosome E.
DR   GO; GO:0010494; C:cytoplasmic stress granule; IEA:EnsemblFungi.
DR   GO; GO:0016281; C:eukaryotic translation initiation factor 4F complex; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR   GO; GO:0098808; F:mRNA cap binding; IEA:EnsemblFungi.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:EnsemblFungi.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:EnsemblFungi.
DR   GO; GO:1901195; P:positive regulation of formation of translation preinitiation complex; IEA:EnsemblFungi.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:EnsemblFungi.
DR   Gene3D; 3.30.760.10; -; 1.
DR   InterPro; IPR023398; TIF_eIF4e-like.
DR   InterPro; IPR001040; TIF_eIF_4E.
DR   InterPro; IPR019770; TIF_eIF_4E_CS.
DR   PANTHER; PTHR11960; PTHR11960; 1.
DR   Pfam; PF01652; IF4E; 1.
DR   SUPFAM; SSF55418; SSF55418; 1.
DR   PROSITE; PS00813; IF4E; 1.
PE   3: Inferred from homology;
KW   Initiation factor; Protein biosynthesis; Reference proteome; RNA-binding;
KW   Translation regulation.
FT   CHAIN           1..209
FT                   /note="Eukaryotic translation initiation factor 4E"
FT                   /id="PRO_0000193650"
FT   CONFLICT        103
FT                   /note="S -> E (in Ref. 1; BAA93571)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   209 AA;  23899 MW;  D09A075213EAC00E CRC64;
     MSVDEVTKKF EETVSVDGPK TVLSDAKDFE VKHPLNTKWT LWYTKPAVDK SESWSDLLRP
     VTSFQSVEEF WAIVQNIPEP HELPLKSDYH VFRNDIRPEW EDSANAKGGK WSFQVRGRGA
     EIDELWLRTL LAVIGETIDE EDSQINGVVL NVRKGGNRFA LWTKSCDKEP LSNIGARFKQ
     VLKLADEDTL EFFPHSTAND RHSQPTITL