ID   IF4G2_CHICK             Reviewed;          73 AA.
AC   O73777;
DT   30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Eukaryotic translation initiation factor 4 gamma 2;
DE            Short=eIF-4-gamma 2;
DE            Short=eIF-4G 2;
DE            Short=eIF4G 2;
DE   AltName: Full=p97;
DE   Flags: Fragment;
GN   Name=EIF4G2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000312|EMBL:AAC06019.1};
RN   [1] {ECO:0000312|EMBL:AAC06019.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RA   Sevigny M.B., Won M., Troy F.A. II;
RT   "Embryonic chick brain mRNA homologous to human p97 and rabbit NAT1,
RT   partial cds.";
RL   Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Appears to play a role in the switch from cap-dependent to
CC       IRES-mediated translation during mitosis, apoptosis and viral
CC       infection. Cleaved by some caspases and viral proteases (By
CC       similarity). {ECO:0000250|UniProtKB:P78344}.
CC   -!- SUBUNIT: Interacts with the serine/threonine protein kinases MKNK1 and
CC       MKNK2. Binds EIF4A and EIF3 (By similarity). {ECO:0000250}.
CC   -!- PTM: Phosphorylation; hyperphosphorylated during mitosis.
CC       {ECO:0000250|UniProtKB:P78344}.
CC   -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC       {ECO:0000305}.
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DR   EMBL; AF052193; AAC06019.1; -; mRNA.
DR   AlphaFoldDB; O73777; -.
DR   SMR; O73777; -.
DR   STRING; 9031.ENSGALP00000039068; -.
DR   PaxDb; O73777; -.
DR   VEuPathDB; HostDB:geneid_395905; -.
DR   eggNOG; KOG0401; Eukaryota.
DR   HOGENOM; CLU_001519_3_0_1; -.
DR   InParanoid; O73777; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR045208; IF4G.
DR   InterPro; IPR003307; W2_domain.
DR   PANTHER; PTHR23253; PTHR23253; 1.
DR   Pfam; PF02020; W2; 1.
DR   SMART; SM00515; eIF5C; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS51363; W2; 1.
PE   2: Evidence at transcript level;
KW   Initiation factor; Phosphoprotein; Protein biosynthesis;
KW   Reference proteome; Repressor; Translation regulation.
FT   CHAIN           <1..73
FT                   /note="Eukaryotic translation initiation factor 4 gamma 2"
FT                   /id="PRO_0000213328"
FT   DOMAIN          1..70
FT                   /note="W2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00695"
FT   NON_TER         1
FT                   /evidence="ECO:0000312|EMBL:AAC06019.1"
SQ   SEQUENCE   73 AA;  8764 MW;  42D8A7B6F496ED4D CRC64;
     QVHCYNSNFP KGMLLRFFVH FYDMEIIEEE AFLAWKEDIT QEFPGKGKAL FQVNQWLTWL
     ETAEEEESEE EAD