IF4G_DICDI
ID IF4G_DICDI Reviewed; 1377 AA.
AC Q553R3;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Eukaryotic translation initiation factor 4 gamma;
DE Short=eIF-4-gamma;
GN Name=eif4g; ORFNames=DDB_G0275395;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Probable component of the protein complex eIF4F, which is
CC involved in the recognition of the mRNA cap, ATP-dependent unwinding of
CC 5'-terminal secondary structure and recruitment of mRNA to the
CC ribosome. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000013; EAL69763.1; -; Genomic_DNA.
DR RefSeq; XP_643657.1; XM_638565.1.
DR AlphaFoldDB; Q553R3; -.
DR SMR; Q553R3; -.
DR STRING; 44689.DDB0234257; -.
DR PaxDb; Q553R3; -.
DR EnsemblProtists; EAL69763; EAL69763; DDB_G0275395.
DR GeneID; 8619923; -.
DR KEGG; ddi:DDB_G0275395; -.
DR dictyBase; DDB_G0275395; eIF4g.
DR eggNOG; KOG0401; Eukaryota.
DR HOGENOM; CLU_255900_0_0_1; -.
DR InParanoid; Q553R3; -.
DR OMA; KLECFCK; -.
DR Reactome; R-DDI-1169408; ISG15 antiviral mechanism.
DR Reactome; R-DDI-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-DDI-166208; mTORC1-mediated signalling.
DR Reactome; R-DDI-72662; Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S.
DR Reactome; R-DDI-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-DDI-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-DDI-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:Q553R3; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; ISS:dictyBase.
DR GO; GO:0016281; C:eukaryotic translation initiation factor 4F complex; ISS:dictyBase.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; ISS:dictyBase.
DR GO; GO:0006446; P:regulation of translational initiation; ISS:dictyBase.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045208; IF4G.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR PANTHER; PTHR23253; PTHR23253; 1.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
DR PROSITE; PS51366; MI; 1.
PE 3: Inferred from homology;
KW Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..1377
FT /note="Eukaryotic translation initiation factor 4 gamma"
FT /id="PRO_0000333880"
FT DOMAIN 1182..1305
FT /note="MI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT REGION 1..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1041..1063
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..114
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..434
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..470
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..513
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1049..1063
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1377 AA; 154713 MW; 357E2AD0591CCB93 CRC64;
MNFRYQPNQQ PYQPPQHNNN SNNRGIPTNY QQYPPQNYQQ YPPQQYYQAP INPQQFYPGP
PQQPNFVSQQ TGPIPQQPPG FNNQSPIPQQ QPQQPQQPQP SQPSPIPQQP LSPQSSSPSS
PQHVVIQPNQ PNQQQQNANR KQSALKPSVQ HNTIPNIPRT HSAPPSLEEQ QQQHQHQNNI
KGFTPEKRTP IQHSPQYVIP PQQFGKPIYP NPQQMYFQQQ PPYPYYGQPP VVPVVNQMIP
QTTVKKTLEI IDPKTNEKVI ITSPPKSSTN STVLPTSNTS SSSSSPTNAN GSSTPSGSGY
VTSFSSGNVN LRKNKQSGET TPIKQDAAST TTSTPATPSS KAESTTEAET TSKPSTPTTV
DSVSSTTTPD KSNVVTAAAT TTAAATTTTT TTDTTTTTTT PEAETSTTTP ATEVQSPVET
TKEEQPKEEV KPTEVQPPVE PTKEEPIKEE PTNEEPTKEE PAKVEPIKEE PSVVESTTTD
TKEEPIIVAE EKKQEETPVT PVTEKKEEPI VKPETPVTDS TAASTTVEKE STDSTTTATV
STTAAATTTN GKVEEELEEW EKKGEEDFNI VQSSDSSTSI TPATSLVFRN SGEKIVYSKE
LMMSLKPKSM EEPTGPLKDL KNQIETNTNQ NQLNRSGNKI GGNQQNKNMG MGGMNMNPNY
PPQMNMKYPP QMNMKYPPKN YNNQVQGQQQ QQQGNPNFNK YAPGYQYQQQ IQQGMPPPTL
QPNPYQPQQA TYGITFSRDP VQPSISSQPV NEKRWVPTKV NALDDSQKVL RKANFILNKI
TPEKFDVLTE ELLELGIVDD EKVHKGTIDL IFDKALNESK FCTMYTNLCK KIFEFEKVKK
EIAKRAVFEK IGVIETENYH KMSNKQRDEF DQEHNVKAVF RTLLLSTCQK EYEKIPFETV
DKVPEDLKPE EKTDFEEGQF KERKRIFGLI KFIGELFKQQ MLSEKIVHGI MVSLIGELQR
PSEIKLECFC KLLSIVGKTL SQNEQASKYL TSYFQRMQQL VDNSQTLSQR IRFLIQNVMD
LKNSNWTLKV DESAKTLKEV EATQNKQEDN RKSNPTGVKN TSNVKNMFNA SFNFGGPNVK
PMMAPPMNYN KNAPGIKPPA QFQPKPYPYN NNYNNQQQQQ QHFGGGNNMM NNNNNNYNRG
PMGNMNNNMN NNMNNNNMNN MNSNNSTSNN SANSEIQKKW DAVSTSITDS INEFLELKDE
EEFMECVKSY VPSTDLYPHV ISQLISTACS KQKDEPLIKK LIFASVFDKK LFTTAQFKSG
YELFISSLPD LFEDRPSAFK SVASVFYSFV LNQEGLITIT QFANAFTKVL DDCGSSIPKI
LFEFILQFED PKKAAQLFVD NKVGVQGFFT EKDFSKITQT AISYNKDLQP FFDIVKL
