ID   IF4G_ENCCU              Reviewed;         610 AA.
AC   Q8SVP8;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2013, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Probable eukaryotic translation initiation factor 4 gamma homolog;
DE            Short=eIF-4-gamma;
GN   Name=EIF4G; OrderedLocusNames=ECU04_1610;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=GB-M1;
RX   PubMed=20003517; DOI=10.1186/1471-2164-10-607;
RA   Peyretaillade E., Goncalves O., Terrat S., Dugat-Bony E., Wincker P.,
RA   Cornman R.S., Evans J.D., Delbac F., Peyret P.;
RT   "Identification of transcriptional signals in Encephalitozoon cuniculi
RT   widespread among Microsporidia phylum: support for accurate structural
RT   genome annotation.";
RL   BMC Genomics 10:607-607(2009).
CC   -!- FUNCTION: Component of the protein complex eIF4F, which is involved in
CC       the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal
CC       secondary structure and recruitment of mRNA to the ribosome.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the eIF4F complex, which composition varies with
CC       external and internal environmental conditions. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC       {ECO:0000305}.
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DR   EMBL; AL590444; CAD25350.2; -; Genomic_DNA.
DR   RefSeq; NP_584846.1; NM_001041196.1.
DR   AlphaFoldDB; Q8SVP8; -.
DR   SMR; Q8SVP8; -.
DR   STRING; 284813.Q8SVP8; -.
DR   GeneID; 858994; -.
DR   KEGG; ecu:ECU04_1610; -.
DR   VEuPathDB; MicrosporidiaDB:ECU04_1610; -.
DR   HOGENOM; CLU_446896_0_0_1; -.
DR   InParanoid; Q8SVP8; -.
DR   OrthoDB; 612910at2759; -.
DR   Proteomes; UP000000819; Chromosome IV.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR045208; IF4G.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   PANTHER; PTHR23253; PTHR23253; 1.
DR   Pfam; PF02854; MIF4G; 1.
DR   SMART; SM00543; MIF4G; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   RNA-binding; Translation regulation.
FT   CHAIN           1..610
FT                   /note="Probable eukaryotic translation initiation factor 4
FT                   gamma homolog"
FT                   /id="PRO_0000388435"
FT   DOMAIN          175..414
FT                   /note="MIF4G"
FT   REGION          59..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..92
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        93..118
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   610 AA;  70279 MW;  126551D98E1C6187 CRC64;
     MIKKIIHRPK RSLFVFKKEE SLLYGPRVKS APPIEISFEP PAKIEPKLAV RFTRADGTPI
     RKEDLLDSTD SEILSESSVE SETEVENIPQ EADTGNTREE SEECQREAGA EEEPRPALED
     RALMLDNLLK RFSEQKIAEN RGPCYSVDEI LSVEDRKAIS LELKIKTRKE AKGVYRPDNN
     RKDTCIEQAR LEFNRLTAKN IGLVIKNLKA IRVGTIEEMK EIAKILFDKA ISEPTFVKYY
     ALLVLDLKKE WQSEEEKTRD ITQTVFFGTL LTLTLKTLEN KERWGDEYER RKEMSFEERM
     AYEEKLEEAE TERYIKKRRT LGTIDFLSSL YSLNVISYVH MNACINTLMK LDDSENVEVL
     CYLIENIGEK LVVSGKEHII SMVCSSLAQK KNSYTNRIRY MIESLLDKRS SWKPREAKAG
     NVFSCLEVEN DYGNAQNQGS QESPSEDVLP FLSSLSEELS VAYEDDDKEL LSDSLQSGES
     KFGVIPFYLS YFQEAISNHK VSDLLSDFFI SFRSTSSITE EQLREVLLSL KGDLDVLKID
     FPISPKKYSE LITKLRASKV ISQPLFEELK TSDYNSRATD IILRWYKSDR DREKALTIFP
     SEAIENLIRK