ID   IF4G_ENTBH              Reviewed;         578 AA.
AC   B7XJR9;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Probable eukaryotic translation initiation factor 4 gamma homolog;
DE            Short=eIF-4-gamma;
GN   Name=EIF4G; ORFNames=EBI_21783;
OS   Enterocytozoon bieneusi (strain H348) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Enterocytozoonidae;
OC   Enterocytozoon.
OX   NCBI_TaxID=481877;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H348;
RX   PubMed=18060071; DOI=10.1371/journal.pone.0001277;
RA   Corradi N., Akiyoshi D.E., Morrison H.G., Feng X., Weiss L.M., Tzipori S.,
RA   Keeling P.J.;
RT   "Patterns of genome evolution among the microsporidian parasites
RT   Encephalitozoon cuniculi, Antonospora locustae and Enterocytozoon
RT   bieneusi.";
RL   PLoS ONE 2:E1277-E1277(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H348;
RX   PubMed=19132089; DOI=10.1371/journal.ppat.1000261;
RA   Akiyoshi D.E., Morrison H.G., Lei S., Feng X., Zhang Q., Corradi N.,
RA   Mayanja H., Tumwine J.K., Keeling P.J., Weiss L.M., Tzipori S.;
RT   "Genomic survey of the non-cultivatable opportunistic human pathogen,
RT   Enterocytozoon bieneusi.";
RL   PLoS Pathog. 5:E1000261-E1000261(2009).
CC   -!- FUNCTION: Component of the protein complex eIF4F, which is involved in
CC       the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal
CC       secondary structure and recruitment of mRNA to the ribosome.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the eIF4F complex, which composition varies with
CC       external and internal environmental conditions. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC       {ECO:0000305}.
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DR   EMBL; ABGB01000033; EED43823.1; -; Genomic_DNA.
DR   RefSeq; XP_002650247.1; XM_002650201.1.
DR   AlphaFoldDB; B7XJR9; -.
DR   SMR; B7XJR9; -.
DR   EnsemblFungi; EED43823; EED43823; EBI_21783.
DR   VEuPathDB; MicrosporidiaDB:EBI_21783; -.
DR   HOGENOM; CLU_471742_0_0_1; -.
DR   InParanoid; B7XJR9; -.
DR   Proteomes; UP000001742; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR016024; ARM-type_fold.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   RNA-binding; Translation regulation.
FT   CHAIN           1..578
FT                   /note="Probable eukaryotic translation initiation factor 4
FT                   gamma homolog"
FT                   /id="PRO_0000388436"
FT   DOMAIN          156..378
FT                   /note="MIF4G"
SQ   SEQUENCE   578 AA;  67215 MW;  66E2F8FFBDDF2316 CRC64;
     MSNKSYDNNV NINERKTQKK FILTTTEGKP LKFNLKDSNS DIEIESEVSN NDMVDTSQHF
     HKNNIVMKTT LNDDINHILK KETKIDELSR IDQFKIIEWL YIKLNRSNAT DMLLEEVIEN
     LKKPKSEISL NLILRKREKT MSEKLKNLKE KKYSCLEIAK LQFNKVTLDK ISLFSKEILD
     LKINTVDEMK ELASFVFVKA ITEKAFLDTY TKLIGILKKN FKCAEEKNMG KESTCFFASL
     LKLMMKKIEE NHTFNRDIYI DKENKTEIEI EEEIENAELA RKLKRTQAIG AISFCVSLYK
     NSITGVANIK NTVNFLTKKP SSENIELLCE ILRQGGPQLN INHSETVNQI LHYIETHNIY
     GPRMEIIIEQ TIEKLKREIK LNNVSTKSSN IFANLFISNT GIAENGKKIN EREDIEKYFE
     EEILPGLGSC YEIADLEDMV DIIVHGFNQF NQSEFVFHYF TYVVTDNKNG TKLIELYSVF
     LADIISNKDV NIFSIIKRIK NDLNIYYIDY PCSKIKYPEM LCFVKSTGKI TNEEFNALKV
     PDFEIKVKDL VYKWHSTSDE RLHAVFNNCD IDRIINAL