ID   IF4G_NOSCE              Reviewed;         598 AA.
AC   C4V8K5;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Probable eukaryotic translation initiation factor 4 gamma homolog;
DE            Short=eIF-4-gamma;
GN   Name=EIF4G; ORFNames=NCER_100836;
OS   Nosema ceranae (strain BRL01) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nosematidae; Nosema.
OX   NCBI_TaxID=578460;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BRL01;
RX   PubMed=19503607; DOI=10.1371/journal.ppat.1000466;
RA   Cornman R.S., Chen Y.P., Schatz M.C., Street C., Zhao Y., Desany B.,
RA   Egholm M., Hutchison S., Pettis J.S., Lipkin W.I., Evans J.D.;
RT   "Genomic analyses of the microsporidian Nosema ceranae, an emergent
RT   pathogen of honey bees.";
RL   PLoS Pathog. 5:E1000466-E1000466(2009).
CC   -!- FUNCTION: Component of the protein complex eIF4F, which is involved in
CC       the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal
CC       secondary structure and recruitment of mRNA to the ribosome.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the eIF4F complex, which composition varies with
CC       external and internal environmental conditions. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC       {ECO:0000305}.
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DR   EMBL; ACOL01000057; EEQ82443.1; -; Genomic_DNA.
DR   RefSeq; XP_002996114.1; XM_002996068.1.
DR   AlphaFoldDB; C4V8K5; -.
DR   SMR; C4V8K5; -.
DR   STRING; 578460.C4V8K5; -.
DR   PRIDE; C4V8K5; -.
DR   EnsemblFungi; EEQ82443; EEQ82443; NCER_100836.
DR   KEGG; nce:NCER_100836; -.
DR   VEuPathDB; MicrosporidiaDB:NCER_100836; -.
DR   HOGENOM; CLU_446896_0_0_1; -.
DR   InParanoid; C4V8K5; -.
DR   OMA; IMEDEPA; -.
DR   Proteomes; UP000009082; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR045208; IF4G.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   PANTHER; PTHR23253; PTHR23253; 1.
DR   Pfam; PF02854; MIF4G; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   RNA-binding; Translation regulation.
FT   CHAIN           1..598
FT                   /note="Probable eukaryotic translation initiation factor 4
FT                   gamma homolog"
FT                   /id="PRO_0000388437"
FT   DOMAIN          209..434
FT                   /note="MIF4G"
FT   REGION          65..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   598 AA;  69759 MW;  0098C68E1D101797 CRC64;
     MVNEVPTLKK KIIFKYFKPL LTFTKKEDPY ELRVKSAPPL NIIEERKEPK KFVLCKPDGT
     PITLDDLSDI SDSEEEEDTK LDMKDSIKED VKDSIKEDVK DSSKEDVKDD VIEDVKGSIN
     EEINSTCGTC SFINLKREKI LNELLEMYRV EESVPYSFVP TNVPQIMYSV GEILNCINKI
     PFTLKLLKKD VNKIPVNYKE FKINKETIIE KATFELNKLT NTNIKRIITN LKNLNIETIQ
     QAKYLGNLIV FKAINEPQYC NLYAMVVGAL KKDFKSKEEL GLHKKQTAFF GTVLTSAMKV
     LEEKVEWADT KVLDKNLYKN AFEYERAFEE QETERYLRKK KTLGAVNLLC DLYNLDVITL
     KHIQSRLNEF LNIENEEVVE VLGKFIEKIG EKMYLNDKSD YANMICSYLD ACKNKYSNRV
     KFYIMDVLDK KKNWKKPVSK TENLFSSLIM EDEPALDTPY QYQEQVIANE EEEDSLELLK
     TIDNIYQDLK DAYDEEDEIM IADNFKIASN TFGKISFFST YFSECITNSR KSKLLVPFVI
     NFFNETNLNE SELFDIINKH KEKLNELKID FPLSQKIMSL YVINFVVDRL SKKIHMIN