IF4G_ORYSJ
ID IF4G_ORYSJ Reviewed; 1792 AA.
AC B9FXV5; Q0D5K1; Q69S49;
DT 09-JAN-2013, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2013, sequence version 2.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Eukaryotic translation initiation factor 4G;
DE Short=eIF-4G;
DE Short=eIF4G;
DE AltName: Full=Eukaryotic initiation factor 4F subunit p220;
DE Short=eIF-4F p220 subunit;
GN OrderedLocusNames=Os07g0555200, LOC_Os07g36940;
GN ORFNames=OsJ_24703, OSJNBa0058I18.6;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP GENE FAMILY.
RX PubMed=17898986; DOI=10.1007/s00122-007-0646-6;
RA Boisnard A., Albar L., Thiemele D., Rondeau M., Ghesquiere A.;
RT "Evaluation of genes from eIF4E and eIF4G multigenic families as potential
RT candidates for partial resistance QTLs to Rice yellow mottle virus in
RT rice.";
RL Theor. Appl. Genet. 116:53-62(2007).
CC -!- FUNCTION: Component of the protein complex eIF4F, which is involved in
CC the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal
CC secondary structure and recruitment of mRNA to the ribosome.
CC -!- SUBUNIT: EIF4F is a multi-subunit complex, the composition of which
CC varies with external and internal environmental conditions. It is
CC composed of at least EIF4A, EIF4E and EIF4G. In higher plants two
CC isoforms of EIF4F have been identified, named isoform EIF4F and isoform
CC EIF(iso)4F. Isoform EIF4F has subunits p220 and p26, whereas isoform
CC EIF(iso)4F has subunits p82 and p28.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD30897.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAF21872.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EEE67392.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AP005125; BAD30897.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008213; BAF21872.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM000144; EEE67392.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AK066706; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK068744; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK069301; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK100968; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015646496.1; XM_015791010.1.
DR AlphaFoldDB; B9FXV5; -.
DR SMR; B9FXV5; -.
DR STRING; 4530.OS07T0555200-01; -.
DR iPTMnet; B9FXV5; -.
DR PaxDb; B9FXV5; -.
DR PRIDE; B9FXV5; -.
DR GeneID; 4343565; -.
DR KEGG; osa:4343565; -.
DR eggNOG; KOG0401; Eukaryota.
DR HOGENOM; CLU_001191_0_0_1; -.
DR InParanoid; B9FXV5; -.
DR OrthoDB; 594395at2759; -.
DR Proteomes; UP000000763; Chromosome 7.
DR Proteomes; UP000007752; Chromosome 7.
DR Proteomes; UP000059680; Chromosome 7.
DR Genevisible; B9FXV5; OS.
DR GO; GO:0016281; C:eukaryotic translation initiation factor 4F complex; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045208; IF4G.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR PANTHER; PTHR23253; PTHR23253; 2.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
DR PROSITE; PS51366; MI; 1.
PE 2: Evidence at transcript level;
KW Initiation factor; Protein biosynthesis; Reference proteome;
KW Translation regulation.
FT CHAIN 1..1792
FT /note="Eukaryotic translation initiation factor 4G"
FT /id="PRO_0000420544"
FT DOMAIN 1183..1406
FT /note="MIF4G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT DOMAIN 1603..1727
FT /note="MI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT REGION 1..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 678..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 873..912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 960..993
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 999..1018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1018..1030
FT /note="EIF4E-binding"
FT /evidence="ECO:0000250"
FT REGION 1275..1299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1407..1503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1537..1600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..109
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..581
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..639
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..693
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..723
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..993
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1017
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1407..1432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1487..1503
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1537..1561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1577..1595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 246
FT /note="K -> R (in Ref. 5; AK068744)"
FT /evidence="ECO:0000305"
FT CONFLICT 989
FT /note="E -> K (in Ref. 5; AK069301)"
FT /evidence="ECO:0000305"
FT CONFLICT 1336
FT /note="K -> R (in Ref. 5; AK066706)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1792 AA; 193533 MW; 8FC8DB05B9FC8144 CRC64;
MSQRGDRGEG HARRPGRSSS FGGGHRGGGG VGGAGKGGGG SSGQPPLATN RSFRKSGNGH
GGHQRAVSQP DTHGFQPAPA PTALQTPPLR PPAPQNAPAH VPVPAPRPQH HDPSGARAPT
LPPSSENTAN APPLKGIPHA APRAPSRISS TSTSQGAPKG GAYNLQFGSF PMNGGTGGST
MQFPARTSSA PPNLDEQKRM QALPEGHKVV PSGLVPQAPK HQQQQQPLQQ QKQQPQSQPP
LQQTRKDVVS SNHSSKPINP HIPSQVKSSV HVSPSVPNVA PPRPPVQQIP GMPMSMPFHH
QAPLQFGGHN PQIPPQGVVP SSLQMSMGLH GANAPQVAQQ MYIPTIQHHH QLQPPTMMHQ
AAGIPYGPAA HQLTQMSGMM NVGVAPQFTP QQPNKYVTGP TRKTTVKITH PDTHEELKLD
KRMDSSGQRG LPSVQQQSQP VSTYGSPMGF YQQNSYNQST MFYPTTSGVG QVPTVSQGPR
FVSTQTVSYI SPSMNTGPGS NKDNLAGSTT SGHSQVTGKP HPAGLHMEKS GVQTVTISAP
PGKSDVNKLK PAEDVVSHRQ KDNEAVSGVR KSGENESKAS PITEKHPTPV SQPLQALAAN
PETTAAASFV VNSVPGDDGK SKESIQRTGS FKDSNKNATK DTRNLSQEPQ SASSAEDLKV
HTSVKDVCCG VSLMESKGVN KESEQTNAAS ASPTEMLKAA DASSIDRSSA RSTSESTENV
QEVGKSDVAI GDSEKSGITN KVSPDLTKDD ISSGSTGNES HEVCTLDLAE QLPVGASNPD
NLDTATSVTD QGQLLKEPSS SVSDENVIMD RSHQSAEKMS DLVDDTVASV ASSETLPESI
IQNANAKGNT SGNQETGSAT SSNILNVLPV PHSVASEDPL KPESMLKDQS SSAPAASARP
VSREKPSVEI TRTKFTAVKK KKRREMLSKA DAAGSSDLYN AYKGPEEKVD FIGASESLDS
SSIADHELPD ESSEKEVNMG EDEGKKKVEL DDWEDAAEMS TPKLERSDSS NQTTEANGRK
RYSRDFLLTL AQSCTNLPVG FQMIEYASVL FPNLAGKSYV VDHPSPGRGA DRPASRGDRR
GVVIEDDRWG KSGHLFGSGR DMSMDNGPPT MNHRGAPGVM RNPRGGLINV GPVAPQMSRS
GSDADRWQQK GIFPSPVTPM QVMHKAEKKY VVGKVSDEEE AKQRQLKAIL NKLTPQNFEK
LFEKVKEVNI DNVATLTGVI SQIFDKALME PTFCEMYANF CFHLAGALPD FSEDNEKITF
KRLLLNKCQE EFERGEREEA EADKTEEEGE IKQTKEEREE KRIRARRRML GNIRLIGELY
KKRMLTERIM HECIKKLLGN YQNPDEENIE ALCKLMSTIG EMIDHAKAKE HMDAYFDIML
KLSTSQQLSS RVRFMLRDSI DLRKNKWQQR RKVEGPKKID EVHRDAAQER HAQSSRLARG
SVVGSGPRRG AAPMDYGPRG SAAALASPSS QQVGHRGMPS HSRGFGTQDI RFEERSPLDH
RTTVLPPRKD EAITLGPQGG LARGMSIRGQ PLISNAELSS ADSRRMVSGP NGYNSASTAR
EEPGSRIPDR SGRIAPNTQF AGPSNRPASQ EGRSGNKLYS EDDLREKSIS AIREYYSAKD
EKEVALCIEE LNAPSFYPSV VSLWVNDSFE RKDMERELLT KLFVSLCNSR NNLLSKSHLT
AGLATVLGSL EDALSDAPRA AEYLGRLLAR FVVESILSLQ EVGTLIEKGG EEPGELVHHG
IGADVLGAVL ESIKVEKGDS FLNEAKASSN LKLEDFRPQH LKRSKLDAFM KA
