IF5A1_SOLTU
ID IF5A1_SOLTU Reviewed; 160 AA.
AC P56333; P56334;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Eukaryotic translation initiation factor 5A-1/2;
DE Short=eIF-5A-1/2;
DE AltName: Full=eIF-4D;
GN Name=EIF5A1;
GN and
GN Name=EIF5A2;
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Irish Cobbler;
RA In J.G., Fujino K., Kikuta Y.;
RT "Nucleotide sequence of five cDNAs encoding eukaryotic translation
RT initiation factor 5A (eIF-5A) from potato.";
RL (er) Plant Gene Register PGR97-147(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44;
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
CC -!- FUNCTION: The precise role of eIF-5A in protein biosynthesis is not
CC known but it functions by promoting the formation of the first peptide
CC bond.
CC -!- PTM: Lys-52 undergoes hypusination, a unique post-translational
CC modification that consists in the addition of a butylamino group from
CC spermidine to lysine side chain, leading to the formation of the
CC unusual amino acid hypusine. eIF-5As are the only known proteins to
CC undergo this modification, which is essential for their function.
CC {ECO:0000250|UniProtKB:Q9XI91}.
CC -!- SIMILARITY: Belongs to the eIF-5A family. {ECO:0000305}.
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DR EMBL; AB004827; BAA20880.1; -; mRNA.
DR EMBL; AB004823; BAA20876.1; -; mRNA.
DR RefSeq; NP_001275082.1; NM_001288153.1.
DR AlphaFoldDB; P56333; -.
DR SMR; P56333; -.
DR STRING; 4113.PGSC0003DMT400020252; -.
DR PRIDE; P56333; -.
DR EnsemblPlants; PGSC0003DMT400020252; PGSC0003DMT400020252; PGSC0003DMG400007830.
DR EnsemblPlants; RHC12H1G0334.2.1; RHC12H1G0334.2.1; RHC12H1G0334.2.
DR GeneID; 102594671; -.
DR Gramene; PGSC0003DMT400020252; PGSC0003DMT400020252; PGSC0003DMG400007830.
DR Gramene; RHC12H1G0334.2.1; RHC12H1G0334.2.1; RHC12H1G0334.2.
DR KEGG; sot:102594671; -.
DR eggNOG; KOG3271; Eukaryota.
DR HOGENOM; CLU_102600_1_0_1; -.
DR InParanoid; P56333; -.
DR OMA; KREDYQV; -.
DR OrthoDB; 1370513at2759; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0045901; P:positive regulation of translational elongation; IBA:GO_Central.
DR GO; GO:0045905; P:positive regulation of translational termination; IEA:InterPro.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR001884; IF5A-like.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR014722; Rib_L2_dom2.
DR InterPro; IPR019769; Trans_elong_IF5A_hypusine_site.
DR InterPro; IPR020189; Transl_elong_IF5A_C.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11673; PTHR11673; 1.
DR Pfam; PF01287; eIF-5a; 1.
DR PIRSF; PIRSF003025; eIF5A; 1.
DR SMART; SM01376; eIF-5a; 1.
DR SUPFAM; SSF50104; SSF50104; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR TIGRFAMs; TIGR00037; eIF_5A; 1.
DR PROSITE; PS00302; IF5A_HYPUSINE; 1.
PE 2: Evidence at transcript level;
KW Hypusine; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..160
FT /note="Eukaryotic translation initiation factor 5A-1/2"
FT /id="PRO_0000142478"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 52
FT /note="Hypusine"
FT /evidence="ECO:0000250|UniProtKB:Q9XI91"
SQ SEQUENCE 160 AA; 17432 MW; E35BDF67185B9551 CRC64;
MSDEEHHFES KADAGASKTY PQQAGTIRKS GYIVIKGRPC KVVEVSTSKT GKHGHAKCHF
VAIDIFNGKK LEDIVPSSHN CDVPHVNRTD YQLIDISEDG FVSLLTENGN TKDDLRLPTD
DALLNQVKGG FEEGKDLVLS VMSAMGEEQI CAVKDIGTKS
