ID   IF5A_SCHMA              Reviewed;          52 AA.
AC   Q26571;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Eukaryotic translation initiation factor 5A;
DE            Short=eIF-5A;
DE   Flags: Fragment;
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Liberian;
RA   Schuessler P.;
RL   Thesis (1996), Heinrich-Heine University / Duesseldorf, Germany.
CC   -!- FUNCTION: mRNA-binding protein involved in translation elongation.
CC       Critical for the efficient synthesis of peptide bonds between
CC       consecutive proline residues. Can resolve ribosomal stalling caused by
CC       consecutive prolines during translation (By similarity). Has an
CC       important function at the level of mRNA turnover, probably acting
CC       downstream of decapping. Involved in actin dynamics and cell cycle
CC       progression, mRNA decay and probably in a pathway involved in stress
CC       response and maintenance of cell wall integrity. Functions as a
CC       regulator of apoptosis (By similarity). {ECO:0000250,
CC       ECO:0000250|UniProtKB:P63241}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Lys-42 undergoes hypusination, a unique post-translational
CC       modification that consists in the addition of a butylamino group from
CC       spermidine to lysine side chain, leading to the formation of the
CC       unusual amino acid hypusine. eIF-5As are the only known proteins to
CC       undergo this modification, which is essential for their function.
CC       {ECO:0000250|UniProtKB:A4GVE9}.
CC   -!- SIMILARITY: Belongs to the eIF-5A family. {ECO:0000305}.
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DR   EMBL; Z48724; CAA88616.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q26571; -.
DR   SMR; Q26571; -.
DR   STRING; 6183.Smp_039400.1; -.
DR   eggNOG; KOG3271; Eukaryota.
DR   HOGENOM; CLU_102600_0_0_1; -.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0045901; P:positive regulation of translational elongation; IEA:InterPro.
DR   GO; GO:0045905; P:positive regulation of translational termination; IEA:InterPro.
DR   Gene3D; 2.30.30.30; -; 1.
DR   InterPro; IPR001884; IF5A-like.
DR   InterPro; IPR014722; Rib_L2_dom2.
DR   InterPro; IPR019769; Trans_elong_IF5A_hypusine_site.
DR   InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR   PANTHER; PTHR11673; PTHR11673; 1.
DR   SUPFAM; SSF50104; SSF50104; 1.
DR   PROSITE; PS00302; IF5A_HYPUSINE; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Elongation factor; Hypusine; Protein biosynthesis;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..>52
FT                   /note="Eukaryotic translation initiation factor 5A"
FT                   /id="PRO_0000142459"
FT   MOD_RES         42
FT                   /note="Hypusine"
FT                   /evidence="ECO:0000250|UniProtKB:A4GVE9"
FT   NON_TER         52
SQ   SEQUENCE   52 AA;  5496 MW;  EE9E3F0E2867CEDD CRC64;
     MGDFGASKTL PKQCSALRKG GHVVMKDRPC KIVEMSTSKT GKHGSAKVHL VG